TY - JOUR T1 - Mechanisms of tolerance and Th2 cell activation in asthma JF - Thorax JO - Thorax SP - 909 LP - 909 DO - 10.1136/thx.2004.la0116 VL - 59 IS - 10 AU - R Baghai-Ravary Y1 - 2004/10/01 UR - http://thorax.bmj.com/content/59/10/909.abstract N2 - ▴ De Heer HJ, Hammad H, Soullié T, et al. Essential role of lung plasmacytoid dentritic cells in preventing athmatic reactions to harmless inhaled antigen. J Exp Med2004;200:89–98OpenUrlAbstract/FREE Full Text ▴ Ostroukhova M, Seguin-Devaux C, Oriss TB, et al. Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest2004;114:28–38OpenUrlCrossRefPubMedWeb of Science Multiple factors are involved in the correct regulation of an immune response to common antigens. Two studies using asthma models in mice provide an insight into the immunological mechanisms of T helper 2 (Th2) cell activation in atopic asthma. There are two subsets of human and mouse dentritic cells (DC): the myeloid (mDC) and plasmacytoid (pDC) types. de Heer et … ER -