PT  - JOURNAL ARTICLE
AU  - H Kobayashi
AU  - S Kanoh
AU  - K Motoyoshi
AU  - S Aida
TI  - Diffuse lung disease caused by cotton fibre inhalation but distinct from byssinosis
AID  - 10.1136/thx.2003.014027
DP  - 2004 Dec 01
TA  - Thorax
PG  - 1095--1097
VI  - 59
IP  - 12
4099  - http://thorax.bmj.com/content/59/12/1095.short
4100  - http://thorax.bmj.com/content/59/12/1095.full
SO  - Thorax2004 Dec 01; 59
AB  - A 66 year old man had inhaled cotton fibre for 50 years at his workplace. He did not have any respiratory symptoms. Chest CT scans revealed diffuse centrilobular and peribronchovascular interstitial thickening. Lung biopsy specimens confirmed the presence of string-like foreign bodies as well as granulomas and fibrosis in the peribronchial region. Infrared spectrophotometry confirmed that the foreign bodies were composed of natural cellulose. This is the first study to show directly by examination of biopsy samples that cotton fibre inhalation can cause diffuse lung disease. The clinical features of the disease were entirely different from those of byssinosis.