RT Journal Article
SR Electronic
T1 Bronchodilation by an inhaled VPAC<sub>2</sub> receptor agonist in patients with stable asthma
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 217
OP 221
DO 10.1136/thorax.58.3.217
VO 58
IS 3
A1 A Lindén
A1 L Hansson
A1 A Andersson
A1 M Palmqvist
A1 P Arvidsson
A1 C-G Löfdahl
A1 P Larsson
A1 J Lötvall
YR 2003
UL http://thorax.bmj.com/content/58/3/217.abstract
AB Background: The synthetic vasoactive intestinal peptide (VIP) analogue Ro 25-1553 is a selective VIP-PACAP type 2 (VPAC2) receptor agonist that causes a bronchodilatory effect in guinea pigs in vivo. The effect of Ro 25-1553 given by inhalation to patients with asthma was studied and compared with that of a long acting β2 adrenoceptor agonist. Methods: Twenty four patients with moderate stable asthma participated in a double blind, randomised, placebo controlled, crossover study. The primary variable was bronchodilatory effect (increase in forced expiratory volume in 1 second, FEV1) after inhalation of Ro 25-1553 (100 μg or 600 μg) and formoterol (4.5 μg), respectively. Putative side effects were characterised by monitoring sitting blood pressure, serum potassium, electrocardiography and echocardiography. Results: Inhalation of 600 μg Ro 25-1553 caused a rapid bronchodilatory effect (geometric mean increase in FEV1 compared with placebo) within 3 minutes of 6% (95% CI 4 to 9), as did inhalation of formoterol (8% (95% CI 5 to 10)). The corresponding maximum bronchodilatory effect during 24 hours was similar for 600 μg Ro 25-1553 (7% (95% CI 4 to 10)) and the reference bronchodilator formoterol (10% (95% CI 7 to 12)). However, for both doses of Ro 25-1553 the bronchodilatory effect was attenuated 5 hours after inhalation whereas formoterol still had a bronchodilatory effect 12 hours after inhalation. Neither Ro 25-1553 nor formoterol produced any clinically relevant side effects. No drug related difference in adverse events was observed. Conclusion: Inhalation of a synthetic selective VPAC2 receptor agonist constitutes a promising approach for bronchodilation in patients with asthma.