PT - JOURNAL ARTICLE AU - Fogel, R B AU - Malhotra, A AU - White, D P TI - Sleep ยท 2: Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome AID - 10.1136/thorax.2003.015859 DP - 2004 Feb 01 TA - Thorax PG - 159--163 VI - 59 IP - 2 4099 - http://thorax.bmj.com/content/59/2/159.short 4100 - http://thorax.bmj.com/content/59/2/159.full SO - Thorax2004 Feb 01; 59 AB - The pathogenesis of airway obstruction in patients with obstructive sleep apnoea/hypopnoea syndrome is reviewed. The primary defect is probably an anatomically small or collapsible pharyngeal airway, in combination with a sleep induced fall in upper airway muscle activity.