RT Journal Article
SR Electronic
T1 Association of IL-1β and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 863
OP 866
DO 10.1136/thorax.56.11.863
VO 56
IS 11
A1 L Joos
A1 L McIntyre
A1 J Ruan
A1 J E Connett
A1 N R Anthonisen
A1 T D Weir
A1 P D Paré
A1 A J Sandford
YR 2001
UL http://thorax.bmj.com/content/56/11/863.abstract
AB BACKGROUND There is increasing evidence that the cytokine network is central to the immunopathology of inflammatory airway diseases. The interleukin 1 (IL-1) receptor antagonist (IL-1RN) is a naturally occurring anti-inflammatory agent that binds to the IL-1 receptor but does not possess agonist activity. Each of the genes of the IL-1 locus on chromosome 2q14 is polymorphic. The IL1RNgene contains an 86 bp tandem repeat and allele 2 of this polymorphism has been associated with various inflammatory diseases. The IL-1β (IL1B) gene contains a promoter polymorphism (C-511T) that has been associated with inflammatory diseases and is in linkage disequilibrium with the IL1RNpolymorphism.METHODS We investigated whether polymorphisms in theIL1B and IL1RNgenes were associated with rate of decline of lung function. Genotypes were determined in 284 smokers with a rapid decline in lung function and 306 smokers with no decline in lung function.RESULTS None of the genotypes was associated with the rate of decline of lung function. However, the distribution of IL1B/IL1RNhaplotypes was different between smokers with a rapid decline in lung function and those with no decline in lung function (p=0.0005).CONCLUSION These results suggest that IL1B/IL1RN haplotypes play a role in the rate of decline in lung function in smokers.