PT  - JOURNAL ARTICLE
AU  - Robert J Burden
AU  - Frank Shann
AU  - Warwick Butt
AU  - Michael Ditchfield
TI  - Tracheobronchial malacia and stenosis in children in intensive care: bronchograms help to predict oucome
AID  - 10.1136/thx.54.6.511
DP  - 1999 Jun 01
TA  - Thorax
PG  - 511--517
VI  - 54
IP  - 6
4099  - http://thorax.bmj.com/content/54/6/511.short
4100  - http://thorax.bmj.com/content/54/6/511.full
SO  - Thorax1999 Jun 01; 54
AB  - BACKGROUND Severe tracheobronchial malacia and stenosis are important causes of morbidity and mortality in children in intensive care, but little is known about how best to diagnose these conditions or determine their prognosis.METHODS The records of all 62 children in whom one or both of these conditions had been diagnosed by contrast cinetracheobronchography in our intensive care unit in the period 1986–95 were studied.RESULTS Seventy four per cent of the 62 children had congenital heart disease; none was a preterm baby with airways disease associated with prolonged ventilation. Fifteen of the children had airway stenosis without malacia; three died because of the stenosis and two died from other causes. Twenty eight of the 47 children with malacia died; only eight children survived without developmental or respiratory handicap. All children needing ventilation for malacia for longer than 14 consecutive days died if their bronchogram showed moderate or severe malacia of either main bronchus (15 cases), or malacia of any severity of both bronchi (three additional cases); all children needing ventilation for malacia for longer than 21 consecutive days died if their bronchogram showed malacia of any severity of the trachea or a main bronchus (three additional cases). These findings were strongly associated with a fatal outcome (p<0.00005); they were present in 21 children (all of whom died) and absent in 26 (of whom seven died, six from non-respiratory causes). They had a positive predictive value for death of 100%, but the lower limit of the 95% confidence interval was 83.9% so up to 16% of patients meeting the criteria might survive.CONCLUSION In this series the findings on contrast cinetracheobronchography combined with the duration of ventilation provided a useful guide to the prognosis of children with tracheobronchomalacia. The information provided by bronchoscopy was less useful.