RT Journal Article
SR Electronic
T1 Inhaled micronised gentamicin powder: a new delivery system.
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 939
OP 940
DO 10.1136/thx.45.12.939
VO 45
IS 12
A1 J M Goldman
A1 S M Bayston
A1 S O'Connor
A1 R E Meigh
YR 1990
UL http://thorax.bmj.com/content/45/12/939.abstract
AB Forty patients undergoing routine bronchoscopy were randomised to receive inhaled micronised gentamicin powder (180 mg) or nebulised gentamicin solution (160 mg) one hour before the procedure. Similar levels of gentamicin were detected in bronchoalveolar lavage fluid in the two groups (micronised powder (n = 20) 9.3 (SD 9.3) mg/l, nebulised solution (n = 20) 8.0 (7.8) mg/l). The micronised gentamicin powder preparation caused cough in half the patients but this did not stop their receiving a full dose. Dry powder gentamicin may be a convenient formulation for long term inhaled treatment if the problem of cough can be overcome.