TY - JOUR T1 - Prazosin in the treatment of chronic asthma. JF - Thorax JO - Thorax SP - 385 LP - 387 DO - 10.1136/thx.43.5.385 VL - 43 IS - 5 AU - S V Baudouin AU - T J Aitman AU - A J Johnson Y1 - 1988/05/01 UR - http://thorax.bmj.com/content/43/5/385.abstract N2 - The role of prazosin, an alpha 1 adrenoceptor blocker, was investigated in patients with chronic stable asthma who continued to have symptoms despite conventional treatment. Forty patients were entered into a double blind, placebo controlled, crossover trial to examine the effect of adding oral prazosin (2 mg twice daily) to previous medication for three weeks. Sixteen patients withdrew from the study. The remaining 24 patients showed no significant change in peak expiratory flow, FEV1, forced vital capacity (FVC), FEV1/FVC ratio, diary card symptom scores, or dose of beta sympathomimetic. ER -