RT Journal Article
SR Electronic
T1 Immediate response to cigarette smoke.
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 417
OP 422
DO 10.1136/thx.37.6.417
VO 37
IS 6
A1 Rees, P J
A1 Chowienczyk, P J
A1 Clark, T J
YR 1982
UL http://thorax.bmj.com/content/37/6/417.abstract
AB Using an automated method of calculating airways resistance in the body plethysmograph, we have investigated changes occurring immediately after inhalation of cigarette smoke. Decreases in specific conductance occurred by the time of the first measurement seven or eight seconds after exposure to single inhalations of cigarette smoke in 12 smokers and 12 non-smokers. Less than half of the initial change was present 40 seconds after the inhalation. Initial responses were greater in the non-smokers. Responses recurred with repeated inhalations in smokers and non-smokers. Prior administration of salbutamol and ipratropium bromide significantly inhibited the response and this inhibition appeared to be greater in non-smokers. Sodium cromoglycate inhaled as a dry powder had no effect on the response.