RT Journal Article
SR Electronic
T1 Histocompatibility antigens in asthma: population and family studies.
JF Thorax
JO Thorax
FD BMJ Publishing Group Ltd and British Thoracic Society
SP 670
OP 676
DO 10.1136/thx.34.5.670
VO 34
IS 5
A1 Turton, C W
A1 Morris, L
A1 Buckingham, J A
A1 Lawler, S D
A1 Turner-Warwick, M
YR 1979
UL http://thorax.bmj.com/content/34/5/670.abstract
AB One hundred and twenty-two patients with intrinsic asthma, extrinsic atopic asthma, or asthma with allergic bronchopulmonary aspergillosis were tissue typed for the HLA A, B, and C loci. No associations were found with any of the clinical groups, or with serum total IgE concentrations. Sixty-eight members of 10 families where more than one member was affected by asthma were studied. The segregation of haplotypes in siblings of the propositi who were or were not affected by asthma did not differ from the predicted segregation, and there were no differences when atopy or serum total IgE were considered. No biologically important association between HLA and asthma has been shown.