PT  - JOURNAL ARTICLE
AU  - Hutchinson, P F
AU  - Harrison, R N
TI  - Effect of acute and chronic beta-blockade on carbon dioxide sensitivity in normal man.
AID  - 10.1136/thx.35.11.869
DP  - 1980 Nov 01
TA  - Thorax
PG  - 869--872
VI  - 35
IP  - 11
4099  - http://thorax.bmj.com/content/35/11/869.short
4100  - http://thorax.bmj.com/content/35/11/869.full
SO  - Thorax1980 Nov 01; 35
AB  - The effect of beta-adrenoceptor antagonists on the respiratory response to carbon dioxide rebreathing was studied in eight normal subjects. Propranolol, atenolol, metoprolol, and placebo were given in random, double-blind fashion. Subjects were studied before each treatment period, after one dose, and after eight days of treatment with each drug. A rebreathing method was used to produce progressive hypercapnia and the respiratory response was assessed by measuring minute ventilation and maximum rate of change of inspiratory mouth pressure. Beta-blockade was assessed by the reduction in heart rate during steady state exercise on a cycle ergometer. There was no change in the respiratory response to carbon dioxide after a single dose or eight days treatment of any drug. All three active drugs produced a significant reduction in exercise heart rate. The forced expiratory volume in one second was not altered by any of the drugs.