PT - JOURNAL ARTICLE AU - Siegler, D AU - Kaye, C M AU - Reilly, S AU - Willis, A T AU - Sankey, M G TI - Serum, saliva, and sputum levels of metronidazole in acute exacerbations of chronic bronchitis. AID - 10.1136/thx.36.10.781 DP - 1981 Oct 01 TA - Thorax PG - 781--783 VI - 36 IP - 10 4099 - http://thorax.bmj.com/content/36/10/781.short 4100 - http://thorax.bmj.com/content/36/10/781.full SO - Thorax1981 Oct 01; 36 AB - We have evaluated the absorption and the penetration of metronidazole into the bronchial secretions and saliva in acute infective exacerbations of chronic bronchitis. Seventeen patients were given 400 mg orally three times daily for seven days and "steady state" levels were measured in serum, saliva, and sputum on the last day of treatment. Mean levels in the three biological fluids were not significantly different. Higher metronidazole levels in sputum tended to occur in patients with higher serum levels. In all but one patient, levels in serum and saliva were well within the therapeutic range. We conclude that this oral regimen results in therapeutic tissue levels in acute exacerbations of chronic bronchitis.