PT  - JOURNAL ARTICLE
AU  - E Neville
AU  - R G Mills
AU  - D K Jash
AU  - D M Mackinnon
AU  - L S Carstairs
AU  - D G James
TI  - Sarcoidosis of the upper respiratory tract and its association with lupus pernio.
AID  - 10.1136/thx.31.6.660
DP  - 1976 Dec 01
TA  - Thorax
PG  - 660--664
VI  - 31
IP  - 6
4099  - http://thorax.bmj.com/content/31/6/660.short
4100  - http://thorax.bmj.com/content/31/6/660.full
SO  - Thorax1976 Dec 01; 31
AB  - In a series of 34 patients with sarcoidosis affecting the upper respiratory tract and nose, 26 had lupus pernio (LP) and 17 had sarcoidosis of the upper respiratory tract (SURT). In nine patients these features coexisted. A patient presenting with SURT carried a 50% risk of developing LP although one feature could be present without the other. Both were disorders of women of the child-bearing years of life. SURT, like LP, was an indicator of chronic fibrotic sarcoidosis, developing insidiously and progressing indolently over the years. It was complicated by ulceration, septal perforation, and LP. Three patients had nasal septal perforations, in two instances following submucous resection. This operation is contraindicated in patients with active sarcoidosis, particularly when granulomas are found on nasal biopsy. The Kveim-Siltzbach skin test was positive in all patients with SURT, making it invaluable in the differential diagnosis of granuloma of the nasal cavity.