TY - JOUR T1 - Bronchial carcinoma in patients with pre-existing unilateral lung disease. JF - Thorax JO - Thorax SP - 650 LP - 651 DO - 10.1136/thx.31.6.650 VL - 31 IS - 6 AU - T Yoneyama AU - T Naruke AU - K Suemasu AU - S Ishikawa Y1 - 1976/12/01 UR - http://thorax.bmj.com/content/31/6/650.abstract N2 - Forty-six cases of primary bronchogenic carcinoma occurring in patients with other unilateral pleuropulmonary diseases were studied. In 37 cases (80-4%) carcinoma developed in the previously healthy lung. All but one squamous-cell carcinoma and all of five undifferentiated small-cell carcinomas developed in the previously healthy lung while 7 of 15 adenocarcinomas were in the lung with impaired ventilation. It is suggested that the bronchial epithelium of the healthy lung is more exposed to exogenous carcinogens than that of the diseased, underventilated lung, resulting in a higher risk of development of squamous-cell and undifferentiated small-cell carcinoma. ER -