eLetters

178 e-Letters

published between 2003 and 2006

  • Acute respiratory effects following use of waterproofing sprays: Some UK experience
    Zoe Tizzard

    Dear Editor

    Heinzer et al.  report cases of severe respiratory effects following exposure to aerosol waterproofing sprays in Switzerland [1]. They report that while there are reports from elsewhere in Europe there are no reports yet from the UK. We report the experience of the National Poisons Information Service (London) [NPIS(L)] with these products in 2003.

    The European Association of Poison...

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  • Using the Number Needed to Treat to Make Decisions About Chemotherapy for Lung Cancer
    Mark D. Siegel

    Dear Editor

    Like Dr. Silvestri, I support a model of shared decision making when considering chemotherapy [1]. Unfortunately, many patients don’t realize that the advantages of chemotherapy are not shared equally by those treated. For example, Spiro et al. show that chemotherapy reduces the risk of death from lung cancer by 9% and 5% at one and two years, respectively [2]. The fact that the reduction benefits o...

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  • "MZ Alpha1-Antitrypsin Genotype Unaffected by Age"
    Morten Dahl

    Dear Editor

    In a recent otherwise excellent editorial in Thorax [1], Dr. Seersholm indicated that our previous results on FEV1 decline based on the Copenhagen City Heart Study [2] are biased. We disagree, and rather believe that our study of the general population is prone to less bias than case-control or family-based studies.

    Dr. Seersholm argues that because we genotyped study participants after measuremen...

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  • Re: Effects of vitamin E in mild-to-moderate asthmatics
    Andrew W Fogarty

    Dear Editor

    The aim of our study was to study ‘the effect of 6 weeks regular supplementation with vitamin E on the clinical control of asthma’ [1]. We thus used a combination of objective and subjective measures of asthma as our outcomes. The entry criteria were designed to be as inclusive as possible and to cover a population with mild to moderate asthma.

    However, as Currie et al highlight our study pop...

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  • Music or Detonation induced Pneumothorax
    Jens-Holger Stellinger

    Dear Editor

      As my Title suggests, I have considered the possibility which would be analogue to a detonation causing ARDS (Adult Respiratory Distress Syndrome). In contrast to the ears, where the middle ear reflex until a certain limit prevents destruction of the tympanic membrane with a time constant of 35 microseconds, the lungs have no reflex damping sudden bursts from heavy sub-woofers working together with...

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  • Reliability of pneumothorax episodes data recording: A four-year prospective study
    Daniel K C Lee

    Dear Editor

    Gupta and colleagues [1] present the epidemiology of pneumothorax in England using national data from the Hospital Episode Statistics for emergency hospital admissions, which in turn is reliant on information provided from local National Health Service (NHS) trusts. However, little is known of the reliability of these locally collected data on the incidence of pneumothorax.

    We prospectively...

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  • Exhaled breath condensate in chronic cough
    Alyn H Morice

    Dear Editor

    We read with interest the recent article by Niimi et al reporting low levels of exhaled breath condensate (EBC) pH in patients with chronic cough [1]. We and others have described low EBC pH in association with airway inflammation in allergic asthma, cystic fibrosis and COPD [2][3][4]. In these studies there is a relatively close association between inflammation and low pH which is shown by the furth...

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  • Effects of vitamin E in mild-to-moderate asthmatics
    Graeme P Currie

    Dear Editor

    Pearson et al [1] have failed to tease out any additional benefit of vitamin E supplementation in mild-to-moderate asthmatics. Before concluding that this is the case, it is relevant to highlight several points in their study.

    It is notable that the authors failed to measure any surrogate marker of inflammation such as exhaled nitric oxide, sputum eosinophils or airway hyperresponsiveness (AHR)...

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  • Delayed neonatal neutrophil apoptosis and chronic lung disease: perinatal influences
    Eleanor J Molloy

    Dear Editor

    The paper by Kotecha et al reveals the important association between delayed pulmonary neutrophil apoptosis and neonatal chronic lung disease. This paper also raises several questions. Did the authors analyse the effect of labour on the neutrophil counts? It would be useful to know the mode of delivery as several papers have shown an effect on systemic neutrophil function and survival. Neutrophil coun...

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  • Re: Does co-morbidity not influence histological confirmation?
    Maryska L Janssen-Heijnen

    Dear Editor

    We agree with Anderson that age and significant co-morbidity might reduce the chances of getting histology. In the population of our study the proportion of patients with a clinical diagnosis was 7%. This proportion varied from almost 3% for patients younger than 65 to 8% for those aged 65-79 and 22% for those aged 80 or older. In patients younger than 65 or in those aged 80 or older this proportio...

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