65 e-Letters

published between 2016 and 2019

  • Chronic e-cigarette exposure in mice induces features of COPD in a nicotine-dependent manner?
    Riccardo Polosa

    F.Guarino and R.Polosa

    We read with great curiosity the article by Garcia-Arcos et al. (1) suggesting nicotine as a novel causative factor for the onset and progression of COPD/emphysema. Chronic nicotine exposure from nebulized e- liquid (in toxic concentrations) appears to modify inflammation, ion conductance and mucociliary function in HBECs and induces airway hyper- reactivity and air space enlargement in A/J...

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  • Response to 'Pulmonary rehabilitation for patients with COPD: integrated care or home alone?'
    Anne E. Holland

    We thank Vanfleteren and colleagues for their comments on our recently published equivalence trial comparing home-based and centre-based pulmonary rehabilitation in people with stable chronic obstructive pulmonary disease (COPD).[1] We agree that there is a compelling need to increase the implementation, utilization and delivery of pulmonary rehabilitation.[2] We welcome further discussion regarding the role of new pulmon...

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  • Pulmonary rehabilitation for patients with COPD: integrated care or home alone?
    Lowie E.G.W. Vanfleteren

    Based on their findings from a prospective, randomized, controlled equivalence trial, Holland and colleagues conclude that a 8-week home- based rehabilitation model produced short-term clinical outcomes that were equivalent to a center-based pulmonary rehabilitation program.[1] To their credit, the authors' recruitment and statistical design were of high quality, as were the outcome measures used. We acknowledge that the...

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  • Hypotheses to explain the reduced sensitivity of tuberculin skin test in BCG immunised young children
    Michael Eisenhut

    In a recent cohort study investigating tuberculin skin test (TST) in relation to interferon gamma release assay (IGRA) responses in exposed children and relating responses to previous BCG immunisation the authors reported a reduced sensitivity of TST using IGRA as a reference standard at all induration thresholds for young children (less than 5 years old) who had a previous BCG immunisation compared to those who didn't(1...

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  • Neurohumoral activation as a link between FEV1 and CVD
    Stefan Andreas

    Dear Editor,

    with the greatest interest I have read the publication "Lung function and airway obstruction: associations with circulating markers of cardiac function and incident heart failure in older men--the British Regional Heart Study" by Wannamethee et al. (Thorax 2016 71:526-534). Analyzing a large database with 13 years of prospective follow up the authors conclude that "reduced FEV1 reflecting airflow ob...

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