54 e-Letters

published between 2015 and 2018

  • Salford NEWS score used incorrectly in paper by Hodgson et al

    We read the paper of Hodgson and colleagues with interest.1 Unfortunately, we note that the Salford-NEWS system (observation chart based on target Oxygen saturation prescription) has been applied in this study to all patients with a diagnosis of acute exacerbation of COPD (AECOPD) whereas we proposed applying this system for all patients at risk of type 2 (hypercapnic) respiratory failure, a group which includes many but not all patients with AECOPD and a number of patients with other conditions.2 Around 86% of those prescribed the lower range of Oxygen saturation (88-92%) in Salford are COPD patients judged to be at risk of hypercapnia, the remainder have conditions such as morbid obesity, neuro-muscular disorders, or complex lung diseases.3 Given this key difference in rationale we suggest that the Salford-NEWS system has been inappropriately applied in this study; hence, the conclusions have to be interpreted with extreme caution.

    When comparing NEWS with Salford-NEWS, it is clear that none of the systems had acceptable sensitivity at score thresholds of 5 and 7, and the most consistently reliable result from using either of them is the negative predictive value, which was similar. It was also evident that Salford-NEWS had better specificity at 91% and 95% compared to 57% and 80% for NEWS at score thresholds of 5 and 7 respectively. Since the increased sensitivity in NEWS is achieved at the expense of high “callout” rates, and low positive predictive value (8%...

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  • Response to: A randomised controlled trial of CPAP vs non-invasive ventilation for initial treatment of obesity hypoventilation syndrome
    Mark E Howard

    Dear Editor, We thank Dr Mansell for her comments regarding our recently published trial. [1] We agree that there are different phenotypic variations within the obesity hypoventilation syndrome (OHS), although it remains to be determined whether OHS with co-existent obstructive sleep apnoea (OSA) responds differently to treatment in comparison to OHS without OSA. [2] Acknowledging that the presence and severity of OSA in...

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  • Comment on: A randomised controlled trial of CPAP versus non-invasive ventilation for initial treatment of obesity hypoventilation syndrome
    Stephanie K. Mansell
    Dear Editor,

    We read with great interest the article by Howard et al[1] and commend the authors on this excellent piece of work. However, we wish to raise several points for consideration of this work in a clinical context. Firstly, it is not clear whether the patients being treated were truly patients with obesity hypoventilation failure (OHS) or whether in fact they had hypercapnic obstructive sleep apnoea (OSA). There is in...

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  • Response to correspondence from Professor Lipworth
    Dale Umetsu

    We thank Professors Lipworth and Anderson for their very thoughtful comments in their response to our piece1, and for pointing out clear strategies for treating obesity-associated asthma without expensive therapies, e.g., with improved delivery of inhaled corticosteroids and/or weight reduction.

    It should be noted however, that the focus of the piece was on mechanisms by which obesity might cause asthma,...

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  • Obesity and asthma - do we need expensive therapies?
    Brian J Lipworth

    We read with interest the state of the art review by Umetsu on mechanisms by which obesity impacts asthma [1]. He has clearly outlined the extent to which molecular targets, both within allergic (T-helper 2 [TH2]) and non-allergic mechanistic pathways of asthma, need further evaluation and drug development for obese asthmatics. This was on the basis that current standard therapies for asthma such as inhaled corticoste...

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  • Authors' Response to: Prediction models for hypersensitivity pneumonitis
    Kerri A. Johannson

    We thank Dr. Lacasse and the HP Study Group for their correspondence regarding 'A diagnostic model for chronic hypersensitivity pneumonitis', and appreciate their thoughtful consideration of our work.(1) We agree that these two studies are complementary, and hope that both will serve to improve diagnostic accuracy in the evaluation of patients with suspected HP. We further concur that much work remains to be done to advan...

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  • Prediction models for hypersensitivity pneumonitis
    Yves Lacasse

    To the Editor,

    The diagnosis of hypersensitivity pneumonitis (HP) is difficult and often relies on an array of clinical symptoms and signs developed in an appropriate setting, with the demonstration of radiographic and tomographic abnormalities, serum precipitating antibodies against offending antigens, a lymphocytic alveolitis on bronchoalveolar lavage, and/or a granulomatous reaction on lung biopsies. Taken...

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  • Inspiratory Muscle Training - The need for multiple tests to assess effectiveness
    Ashwin Rajhan

    We would like to congratulate Bissett et al on performing a clinically important study in a challenging cohort of Intensive Therapy Unit (ITU) patients. Any information in assisting the weaning process of ITU patients is clearly very important and clinically very useful.

    It is interesting that Maximum Inspiratory Pressure (MIP) was used to assess the inspiratory muscle strength (IMS), one of the primary endpoint...

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  • Re:Hypotheses to explain the reduced sensitivity of tuberculin skin test in BCG immunised young children
    James A. Seddon

    Dear Editor,

    We appreciate the comments by Dr Eisenhut.(1) We did not focus on the sensitivity analysis in our study as we were primarily interested in establishing the impact of BCG on interpretation of tuberculin skin test (TST) responses, which we considered especially relevant in the context of the new NICE guidance.(2) The points raised by Dr Eisenhut are interesting and we agree that the hypotheses put forwa...

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  • Chronic e-cigarette exposure in mice induces features of COPD in a nicotine-dependent manner?
    Riccardo Polosa

    F.Guarino and R.Polosa

    We read with great curiosity the article by Garcia-Arcos et al. (1) suggesting nicotine as a novel causative factor for the onset and progression of COPD/emphysema. Chronic nicotine exposure from nebulized e- liquid (in toxic concentrations) appears to modify inflammation, ion conductance and mucociliary function in HBECs and induces airway hyper- reactivity and air space enlargement in A/J...

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