eLetters

206 e-Letters

published between 2014 and 2017

  • Hypotheses to explain the reduced sensitivity of tuberculin skin test in BCG immunised young children
    Michael Eisenhut

    In a recent cohort study investigating tuberculin skin test (TST) in relation to interferon gamma release assay (IGRA) responses in exposed children and relating responses to previous BCG immunisation the authors reported a reduced sensitivity of TST using IGRA as a reference standard at all induration thresholds for young children (less than 5 years old) who had a previous BCG immunisation compared to those who didn't(1...

    Show More
  • Neurohumoral activation as a link between FEV1 and CVD
    Stefan Andreas

    Dear Editor,

    with the greatest interest I have read the publication "Lung function and airway obstruction: associations with circulating markers of cardiac function and incident heart failure in older men--the British Regional Heart Study" by Wannamethee et al. (Thorax 2016 71:526-534). Analyzing a large database with 13 years of prospective follow up the authors conclude that "reduced FEV1 reflecting airflow ob...

    Show More
  • Arterial O2 saturation vs O2 extraction ratio during permissive hypercapnia
    Mohamad Abdelsalam Abdelkader

    Dear Editor

    Lung-protective ventilation with low tidal volume (6 ml/Kg of ideal body weight) and maintenance of the plateau airway pressure below 30 cm H2O has now become the standard ventilatory strategy for patients with acute respiratory distress syndrome (ARDS). The ARDS Network trial demonstrated significant reduction of mortality among patients with low tidal volume (6 ml/kg of IBW) as compared wi...

    Show More
  • Complexities of pulmonary dysfunction following cardiopulmonary bypass
    Calvin S.H. Ng

    Dear Editor,

    We congratulate Elkington and Friedland on their excellent review which gives an overview of matrix metalloproteinases (MMPs) in various destructive pulmonary diseases.[1] MMPs and neutrophil elastase do indeed play instrumental roles in the development of ARDS and lung injury following cardiopulmonary bypass (CPB), however, the mechanisms presented may be too simplified.[2]

    Apart from...

    Show More
  • COPD outcomes in ICU
    Luke S Howard

    Dear Editor

    The data presented by Breen et al[1] regarding the outcomes of patients with COPD are encouraging and lend support to the respiratory physician often faced with nihilistic attitudes towards ventilating these patients in acute respiratory failure. However, despite the proposition by the authors that certain patients with likely poor outcomes might have been excluded, the ICU stays for both gr...

    Show More
  • Delayed neonatal neutrophil apoptosis and chronic lung disease: perinatal influences
    Eleanor J Molloy

    Dear Editor

    The paper by Kotecha et al reveals the important association between delayed pulmonary neutrophil apoptosis and neonatal chronic lung disease. This paper also raises several questions. Did the authors analyse the effect of labour on the neutrophil counts? It would be useful to know the mode of delivery as several papers have shown an effect on systemic neutrophil function and survival. Neutrophil coun...

    Show More
  • The authors’ response to Dr Quanjer
    Pim A de Jong

    Dear Editor,

    We appreciate the comments made by Prof. Quanjer concerning our manuscript (1) and fully agree with his comments. In his letter to the editor Prof. Quanjer gives valuable background information to the reasons why pulmonary function tests are relatively insensitive to track pulmonary changes in the longitudinal follow up of cystic fibrosis (CF) lung disease (2). We agree with his arguments that this is...

    Show More
  • High-dose of Fluticasone propionate in mild asthmatics
    S K Agarwal

    Dear Editor

    In a study [1] by Ward et al the dose of fluticasone propionate used for mild asthmatics was several folds higher (1500 mcg) whereas the recommended dose in different International guidelines is only 200 mcg.The other flaws which need clarification are:
    a) Inhaled corticosteroid was withdrawn 3 months before putting the patients on this study; there is no mention of the number of puffs o...

    Show More
  • Effects of vitamin E in mild-to-moderate asthmatics
    Graeme P Currie

    Dear Editor

    Pearson et al [1] have failed to tease out any additional benefit of vitamin E supplementation in mild-to-moderate asthmatics. Before concluding that this is the case, it is relevant to highlight several points in their study.

    It is notable that the authors failed to measure any surrogate marker of inflammation such as exhaled nitric oxide, sputum eosinophils or airway hyperresponsiveness (AHR)...

    Show More
  • Single- or multi-detector row CT in diagnosing PE: a never ending debate?
    Mathilde Nijkeuter

    Dear Editor,

    We would like to comment to the limitations of the Christopher-study (JAMA 2006;295) mentioned by Dr. Bari. He states that “the limitations of this study include the use of two different kinds of CT scanner (multi- detector and single-detector) with potentially different pick up rates”. The other limitation stated is: “the prevalence of PE of 23.2% in the ‘clinically unlikely PE and abnormal D-dimer’...

    Show More

Pages