eLetters

129 e-Letters

published between 2004 and 2007

  • Tissue Oxygenation - Oriented Approach to Patients With ARDS
    Mohamad Abdelsalam Abdelkader

    Dear Editor

    Despite the great advances in critical care medicine, mortality of ARDS is still high. Protective ventilatory strategy - utilizing lower tidal volumes - has been used to reduce mortality of ARDS. Both conventional and protective ventialtory strategies aim to achieve satisfactory arterial rather than tissue oxygenation.According to protective strategy, PEEP is used - even with acceptable SPO2...

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  • Urinary leukotriene LTE4 levels in non-responders to antileukotriene therapy
    Daniel K C Lee

    Dear Editor

    I read with interest the recent article by Green et al. [1] showing that in acute asthma, activation of leukotriene pathways correlated with the degree of airflow obstruction, and a reduction in leukotriene levels was associated with resolution of asthma exacerbation.

    However, no analysis was performed on patients categorised as being in the treatment failure group, which was reported to...

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  • Other non asbestos causes of mesothelioma besides the SV40 virus
    John H. Lange

    Dear Editor

    In reviewing the literature on non-asbestos causes of mesothelioma I located the paper by Baldi et al.[1]

    This paper provides excellent evidence supporting a molecular mehanism on the pathology of mesothelioma. It is mentioned in passing that there may be other causes of mesothelioma besides asbestos. Certainly this paper suggests the SV40 virus as one of these other agents/factors. When...

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  • Resveratrol/COPD
    Andreas C-G v.Glehn

    Dear Editor

    Regarding the article by Culpitt et al.[1] I wish to comment on the use of Resveratrol and the claims made with regard to COPD. I would interested in learning what evidence the authors have for the claims made. I have, after reading the report and as a patient, tested Resveratrol for 9 weeks without absolutely any result! There were no indications of influence on the immune system or inflammato...

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  • Author's reply
    Ajit Lalvani

    Dear Editor

    I thank Mishra and colleagues for their cogent comments about the potential clinical utility of ELISPOT for diagnosis of tuberculosis infection in high burden countries, such as India.[1]

    The high prevalence of latent tuberculosis infection in Indian adults [2] means that ELISPOT (as with any test of tuberculosis infection, as opposed to active disease) cannot be used to routinely ‘rule in’ a...

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  • Meta-analysis
    Jonathan Ilowite

    Dear Editor

    I was excited by this study which shows a decline in the rate of decline in lung function in COPD with inhaled steroids. Although small, this effect could be significant over time, with the potential to delay the onset of debilitating symptoms with this disease. However, the study seems to use similar methadology to a recently published study in another journal which reached the opposite conclusion.[1]...

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  • Early-life antibiotics and asthma
    Mike Thomas

    Dear Editor

    Cullinan et al. [1] present interesting data on the association between antibiotic exposure in early life and the subsequent expression of atopy and asthma. In keeping with other studies they report a positive association between antibiotic receipt over the first 5 years of life and asthma. The association was however largely accounted for by prescriptions issued for respiratory illnesses, and th...

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  • Use of ELISPOT for latent tuberculosis: utility in countries with a high burden of infection.
    Pravas Pratap Mishra

    Dear Editor

    We read with interest your article for detection of latent tuberculosis.[1]

    As the author has pointed out, this test is perhaps more useful for those countries with a low burden of infection. However, even then, it is surprising that there is only one study on Indian subjects.[2] Using this test, the authors recorded a 80% prevalence for latent tuberculosis in healthy adult Indians, compared t...

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  • NOx and diesel exposure
    Per Nafstad

    Dear Editor

    Michal J Collins' letter of 11th December 2003[1] raises an interesting question on the correlations between NOX and diesel exhaust exposure. I’m afraid that we based on our data cannot add more to this discussion, as we were not able to include measurements of diesel exhaust or of particles in general, simply because they were never made. During the 25 years the sources of particles in Oslo has chang...

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