eLetters

119 e-Letters

published between 2001 and 2004

  • Authors' response
    K F Chung

    Dear Editor

    We thank Professor Morice and his colleagues for their interest and for the issues raised vis-a-vis our manuscript.

    The main issue raised concerns the possibility that we may have missed gastrooesophageal disorders such as reflux and dysmotility in our cohort of chronic cough patients. In our assessment protocol, we state that we used oesophageal pH measurements in most patients (32 out of 50)...

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  • COPD, restrictive syndrome and inflammation
    Filippo Fimognari

    Dear Editor

    in a recent issue of the Journal, Gan WQ et al. published a systematic review and meta-analysis of 14 reports which confirmed the strong association between COPD and biological markers of systemic inflammation [1]. In 6 reports, COPD was diagnosed according to the presence of a FEV1/FVC ratio lower than 0.7. However, in the remaining 8 studies this measure was not available, and authors assumed as affecte...

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  • Authors' reply
    Niels Seersholm

    Dear Editor

    Morten Dahl and Børge G. Nordestgaard argue against selection bias, if genotyping is performed after lung function tests because a newborn with PiMZ genotype does not change to PiZZ later in life. The latter is obviously true and not the issue. The reason for possible selection bias is that some persons may fail to have genotype performed due to a characteristic of the lung function tests under stud...

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  • Tuberculosis and anti-TNF- treatment
    Prasanta Raghab Mohapatra

    Dear Editor

    Anti TNF treatment should be given after screening for latent tuberculosis as this may result active tuberculosis in these cases [1]. The World Health Organization estimates that at least one-third of the world’s population are infected with TB [2], [3]. 95% of tuberculosis cases and 98% tuberculosis deaths are in the developing countries [2], [3]. It is difficult to rule out latent tuberculosis infection...

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  • Acute respiratory effects following use of waterproofing sprays: Some UK experience
    Zoe Tizzard

    Dear Editor

    Heinzer et al.  report cases of severe respiratory effects following exposure to aerosol waterproofing sprays in Switzerland [1]. They report that while there are reports from elsewhere in Europe there are no reports yet from the UK. We report the experience of the National Poisons Information Service (London) [NPIS(L)] with these products in 2003.

    The European Association of Poison...

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  • Using the Number Needed to Treat to Make Decisions About Chemotherapy for Lung Cancer
    Mark D. Siegel

    Dear Editor

    Like Dr. Silvestri, I support a model of shared decision making when considering chemotherapy [1]. Unfortunately, many patients don’t realize that the advantages of chemotherapy are not shared equally by those treated. For example, Spiro et al. show that chemotherapy reduces the risk of death from lung cancer by 9% and 5% at one and two years, respectively [2]. The fact that the reduction benefits o...

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  • "MZ Alpha1-Antitrypsin Genotype Unaffected by Age"
    Morten Dahl

    Dear Editor

    In a recent otherwise excellent editorial in Thorax [1], Dr. Seersholm indicated that our previous results on FEV1 decline based on the Copenhagen City Heart Study [2] are biased. We disagree, and rather believe that our study of the general population is prone to less bias than case-control or family-based studies.

    Dr. Seersholm argues that because we genotyped study participants after measuremen...

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  • Re: Effects of vitamin E in mild-to-moderate asthmatics
    Andrew W Fogarty

    Dear Editor

    The aim of our study was to study ‘the effect of 6 weeks regular supplementation with vitamin E on the clinical control of asthma’ [1]. We thus used a combination of objective and subjective measures of asthma as our outcomes. The entry criteria were designed to be as inclusive as possible and to cover a population with mild to moderate asthma.

    However, as Currie et al highlight our study pop...

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  • Music or Detonation induced Pneumothorax
    Jens-Holger Stellinger

    Dear Editor

      As my Title suggests, I have considered the possibility which would be analogue to a detonation causing ARDS (Adult Respiratory Distress Syndrome). In contrast to the ears, where the middle ear reflex until a certain limit prevents destruction of the tympanic membrane with a time constant of 35 microseconds, the lungs have no reflex damping sudden bursts from heavy sub-woofers working together with...

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  • Reliability of pneumothorax episodes data recording: A four-year prospective study
    Daniel K C Lee

    Dear Editor

    Gupta and colleagues [1] present the epidemiology of pneumothorax in England using national data from the Hospital Episode Statistics for emergency hospital admissions, which in turn is reliant on information provided from local National Health Service (NHS) trusts. However, little is known of the reliability of these locally collected data on the incidence of pneumothorax.

    We prospectively...

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