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Online First

April 17, 2024

State of the art review
Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders

Haoran Shen, Rui Zheng, Mulong Du, David C Christiani

doi: 10.1136/thorax-2023-221302

April 10, 2024

Editorial
Toxic metals and lung health: silent poisons?

Seif O Shaheen

doi: 10.1136/thorax-2024-221518
Editorial
New path for understanding mucociliary clearance

Timothy E Corcoran

doi: 10.1136/thorax-2024-221551
Images in Thorax
Pulmonary artery-pulmonary artery collaterals in chronic thromboembolic pulmonary hypertension

Sugang Gong, Huiting Li, Lan Wang

doi: 10.1136/thorax-2023-221219
Editorial
Heteroresistance in tuberculosis: are we missing drug-resistant bacteria hiding in plain sight?

Mirae Park, Giovanni Satta, Pranabashis Haldar

doi: 10.1136/thorax-2024-221409

April 04, 2024

Editorial
Extensive airway remodelling in severe COPD imparts resiliency to environmental stressors

Moumita Ghosh, Eszter K Vladar

doi: 10.1136/thorax-2024-221410
Editorial
MAC attack: MSCs and macrophages join forces against chronic lung infection

Hazel Dunbar, Ian James Hawthorne, Karen English

doi: 10.1136/thorax-2024-221637
Editorial
Unravelling the neutrophil enigma: a new insight into RSV-induced bronchiolitis in infants

Frances Susanna Grudzinska, Aaron Scott

doi: 10.1136/thorax-2023-221130
Editorial
Ablation for lung cancer: hot or cold intervention

Pallav L Shah

doi: 10.1136/thorax-2023-221369

March 28, 2024

Editorial
To progress or not to progress: new insights into the evolution of pleuropulmonary blastomas come from studying lung cysts in adolescents and adults with DICER1-related tumour predisposition

Eric Santoni-Rugiu

doi: 10.1136/thorax-2024-221459
State of the art review
Intensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review

M Elizabeth Wilcox, Lisa Burry, Marina Englesakis, Briar Coman, Marietou Daou, Frank MP van Haren, E Wes Ely, Karen J Bosma, Melissa P Knauert

doi: 10.1136/thorax-2023-220036
Paediatric lung disease
Prevalence of lung cysts in adolescents and adults with a germline DICER1 pathogenic/likely pathogenic variant: a report from the National Institutes of Health and International Pleuropulmonary Blastoma/DICER1 Registry

Alexander T Nelson, Lauren M Vasta, Dave Watson, Jung Kim, Anne K Harris, Ana F Best, Laura A Harney, Ann G Carr, Nicole Frederickson, Louis P Dehner, Christian P Kratz, Kelly N Hagedorn, William A Mize, Alexander Ling, Yoav H Messinger, D Ashley Hill, Kris Ann P Schultz, Douglas R Stewart

doi: 10.1136/thorax-2023-221024

March 22, 2024

Respiratory epidemiology
Clinical implications of airway obstruction with normal or low FEV₁ in childhood and adolescence

Hans Jacob Lohne Koefoed, Gang Wang, Ulrike Gehring, Sandra Ekstrom, Inger Kull, Roel Vermeulen, Jolanda M A Boer, Anna Bergstrom, Gerard H Koppelman, Erik Melén, Judith M Vonk, Jenny Hallberg

doi: 10.1136/thorax-2023-220952

March 20, 2024

Editorial
Testosterone and lung function: bigger lungs, slower decline or some combination of both?

Stephen Milne

doi: 10.1136/thorax-2024-221461
Respiratory epidemiology
Effects of testosterone and sex hormone binding globulin on lung function in males and females: a multivariable Mendelian Randomisation study

Diana A van der Plaat, Alexandra Lenoir, Shyamali Dharmage, James Potts, Francisco Gómez Real, Seif O Shaheen, Debbie Jarvis, Cosetta Minelli, Bénédicte Leynaert

doi: 10.1136/thorax-2023-220374
Respiratory infection
Human mesenchymal stromal cells inhibit Mycobacterium avium replication in clinically relevant models of lung infection

Timothy D Shaw, Anna D Krasnodembskaya, Gunnar N Schroeder, Declan F Doherty, Johnatas Dutra Silva, Shikha M Tandel, Yue Su, David Butler, Rebecca J Ingram, Cecilia M O'Kane

doi: 10.1136/thorax-2023-220819

March 18, 2024

Respiratory epidemiology
Distinct trajectories of lung function from childhood to mid-adulthood

Xian Zhang, Andrew R Gray, Robert J Hancox

doi: 10.1136/thorax-2023-220436

March 12, 2024

Critical care
Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes

David Benjamin Antcliffe, Yuxin Mi, Shalini Santhakumaran, Katie L Burnham, A Toby Prevost, Josie K Ward, Timothy J Marshall, Claire Bradley, Farah Al-Beidh, Paula Hutton, Stuart McKechnie, Emma E Davenport, Charles J Hinds, Cecilia M O'Kane, Daniel Francis McAuley, Manu Shankar-Hari, Anthony C Gordon, Julian C Knight

doi: 10.1136/thorax-2023-220538

March 07, 2024

Chronic obstructive pulmonary disease
Female reproductive histories and the risk of chronic obstructive pulmonary disease

Chen Liang, Hsin-Fang Chung, Annette Dobson, Sven Sandin, Elisabete Weiderpass, Gita D Mishra

doi: 10.1136/thorax-2023-220388

March 06, 2024

State of the art review
Adaptive multi-interventional trial platform to improve patient care for fibrotic interstitial lung diseases

Leticia Kawano-Dourado, Tejaswini Kulkarni, Christopher J Ryerson, Pilar Rivera-Ortega, Bruno Guedes Baldi, Nazia Chaudhuri, Manuela Funke-Chambour, Anna-Maria Hoffmann-Vold, Kerri A Johannson, Yet Hong Khor, Sydney B Montesi, Lucilla Piccari, Helmut Prosch, María Molina-Molina, Jacobo Sellares Torres, Iazsmin Bauer-Ventura, Sujeet Rajan, Joseph Jacob, Duncan Richards, Lisa G Spencer, Barbara Wendelberger, Tom Jensen, Melanie Quintana, Michael Kreuter, Anthony C Gordon, Fernando J Martinez, Naftali Kaminski, Victoria Cornelius, Roger Lewis, Wendy Adams, Gisli Jenkins REMAP-ILD consortium

doi: 10.1136/thorax-2023-221148
Respiratory epidemiology
Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study

Sarah Koch, Gabriela Prado Peralta, Anne-Elie Carsin, Alicia Abellan, Celine Roda, Maties Torrent, Carmen Iñiguez, Ferran Ballester, Amparo Ferrero, Carlos Zabaleta, Aitana Lertxundi, Mònica Guxens, Martine Vrijheid, Jordi Sunyer, Maribel Casas, Judith Garcia-Aymerich

doi: 10.1136/thorax-2022-219666

February 28, 2024

Chronic obstructive pulmonary disease
Monocyte NLRP3 inflammasome and interleukin-1β activation modulated by alpha-1 antitrypsin therapy in deficient individuals

Debananda Gogoi, Howard Yu, Michelle Casey, Rory Baird, Azeez Yusuf, Luke Forde, Michael E O' Brien, Jesse R West, Tammy Flagg, Noel G McElvaney, Edward Eden, Christian Mueller, Mark L Brantly, Patrick Geraghty, Emer P Reeves

doi: 10.1136/thorax-2023-221071
Asthma
Airway epithelial cell response to RSV is mostly impaired in goblet and multiciliated cells in asthma

Aurore C A Gay, Martin Banchero, Orestes Carpaij, Tessa M Kole, Leonie Apperloo, Djoke van Gosliga, Putri Ayu Fajar, Gerard H Koppelman, Louis Bont, Rudi W Hendriks, Maarten van den Berge, Martijn C Nawijn

doi: 10.1136/thorax-2023-220230
Asthma
Improved childhood asthma control after exposure reduction interventions for desert dust and anthropogenic air pollution: the MEDEA randomised controlled trial

Panayiotis Kouis, Emmanouil Galanakis, Eleni Michaelidou, Paraskevi Kinni, Antonis Michanikou, Constantinos Pitsios, Julietta Perez, Souzana Achilleos, Nicos Middleton, Pinelopi Anagnostopoulou, Helen Dimitriou, Efstathios Revvas, Gerasimos Stamatelatos, Haris Zacharatos, Chrysanthos Savvides, Emily Vasiliadou, Nikos Kalivitis, Andreas Chrysanthou, Filippos Tymvios, Stefania I Papatheodorou, Petros Koutrakis, Panayiotis K Yiallouros

doi: 10.1136/thorax-2023-220877
Editorial
Neutrophils and RSV: differences with age

Zoe Rooke, Noreen Zainal Abidin, Caroline Harris, Malcolm Brodlie

doi: 10.1136/thorax-2023-221177

February 22, 2024

Paediatric lung disease
Impact of ambient air pollution on lung function in preterm-born school-aged children

William John Watkins, Christopher William Course, Michael Cousins, Kylie Hart, Sarah J Kotecha, Sailesh Kotecha

doi: 10.1136/thorax-2023-220233
Environmental exposure
Comprehensive analysis of environmental exposure to hazardous trace elements and lung function: a national cross-sectional study

Yun-Jiang Yu, Tong Zheng, Jennifer L Perret, Yajing Han, Hongyan Li, Wenjie Meng, Dinh Bui, Qi-Zhen Wu, Chenyin Dong, Qiu-Ling Fang, Zhenchi Li, Hongxuan Kuang, Xiaowen Chen, Mingdeng Xiang, Xiaodi Qin, Shyamali C Dharmage, Guang-Hui Dong, Yang Zhou

doi: 10.1136/thorax-2022-219839

February 20, 2024

Chronic obstructive pulmonary disease
Mucus clears from the trachea in a helix: a new twist to understanding airway diseases

David Abelson, James Di Michiel, Clayton Frater, Mark Pearson, Robert Russo, Martin Wechselberger, Alice Cottee, Lucy Morgan

doi: 10.1136/thorax-2023-221052

February 17, 2024

State of the art review
Invasive versus non-invasive paediatric home mechanical ventilation: review of the international evolution over the past 24 years

Michel Toussaint, Olivier van Hove, Dimitri Leduc, Lise Ansay, Nicolas Deconinck, Brigitte Fauroux, Sonia Khirani

doi: 10.1136/thorax-2023-220888

February 16, 2024

Paediatric lung disease
Neutrophil responses to RSV infection show differences between infant and adult neutrophils

Elisabeth Robinson, Shyam Sawhney, Mario Cortina-Borja, Anna L David, Claire M Smith, Rosalind L Smyth

doi: 10.1136/thorax-2023-220081

February 15, 2024

Respiratory epidemiology
Indirect impact of childhood 13-valent pneumococcal conjugate vaccine (PCV13) in Canadian older adults: a Canadian Immunization Research Network (CIRN) retrospective observational study

Sharifa Nasreen, Jun Wang, Fawziah Marra, Jeffrey C Kwong, Allison McGeer, Manish Sadarangani, Sarah E Wilson, Shaza A Fadel

doi: 10.1136/thorax-2023-220377

February 05, 2024

Environmental exposure
COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors

Mircea Gabriel Stoleriu, Meshal Ansari, Maximilian Strunz, Andrea Schamberger, Motaharehsadat Heydarian, Yaobo Ding, Carola Voss, Juliane Josephine Schneider, Michael Gerckens, Gerald Burgstaller, Alejandra Castelblanco, Teresa Kauke, Jan Fertmann, Christian Schneider, Juergen Behr, Michael Lindner, Elvira Stacher-Priehse, Martin Irmler, Johannes Beckers, Oliver Eickelberg, Benjamin Schubert, Stefanie M Hauck, Otmar Schmid, Rudolf A Hatz, Tobias Stoeger, Herbert B Schiller, Anne Hilgendorff

doi: 10.1136/thorax-2022-219958

January 29, 2024

Tuberculosis
Challenging the gold standard: the limitations of molecular assays for detection of Mycobacterium tuberculosis heteroresistance

Sarah N Danchuk, Ori E Solomon, Thomas Andreas Kohl, Viola Dreyer, Ivan Barilar, Christian Utpatel, Stefan Niemann, Dick van Soolingen, Richard Anthony, Jakko van Ingen, Joy S Michael, Marcel A Behr

doi: 10.1136/thorax-2023-220202

January 19, 2024

Lung cancer
Transbronchial cryoablation in peripheral lung parenchyma with a novel thin cryoprobe and initial clinical testing

Chuanjia Gu, Haibin Yuan, Chi Yang, Fangfang Xie, Junxiang Chen, Lei Zhu, Yifeng Jiang, Jiayuan Sun

doi: 10.1136/thorax-2023-220227

December 04, 2023

Chronic obstructive pulmonary disease
QRISK3 underestimates the risk of cardiovascular events in patients with COPD

Joseph Emil Amegadzie, Zhiwei Gao, Jennifer K Quint, Richard Russell, John R Hurst, Tae Yoon Lee, Don D Sin, Wenjia Chen, Mona Bafadhel, Mohsen Sadatsafavi

doi: 10.1136/thorax-2023-220615

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