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Online First

February 14, 2022

Respiratory infection
Lung directed antibody gene transfer confers protection against SARS-CoV-2 infection

Yue Du, Kamran M Miah, Omar Habib, Helena Meyer-Berg, Catriona C Conway, Mariana A Viegas, Rebecca Dean, Dwiantari Satyapertiwi, Jincun Zhao, Yanqun Wang, Nigel J Temperton, Toby P E Gamlen, Deborah R Gill, Stephen C Hyde

doi: 10.1136/thoraxjnl-2021-217650

February 11, 2022

Interstitial lung disease
Healthcare resource utilisation and medical costs for children with interstitial lung diseases (chILD) in Europe

Elias Seidl, Nicolaus Schwerk, Julia Carlens, Martin Wetzke, Steve Cunningham, Nagehan Emiralioğlu, Nural Kiper, Joanna Lange, Katarzyna Krenke, Nicola Ullmann, Dora Krikovszky, the chILD-EU collaborators, Phillen Maqhuzu, Charlotte A Griese, Larissa Schwarzkopf, Matthias Griese

doi: 10.1136/thoraxjnl-2021-217751
Paediatric lung disease
Acute exacerbations in children’s interstitial lung disease

Elias Seidl, Nicolaus Schwerk, Julia Carlens, Martin Wetzke, Nagehan Emiralioğlu, Nural Kiper, Joanna Lange, Katarzyna Krenke, Zsolt Szepfalusi, Florian Stehling, Winfried Baden, Susanne Hämmerling, Silvija-Pera Jerkic, Marijke Proesmans, Nicola Ullmann, Frederik Buchvald, Katrin Knoflach, Matthias Kappler, the chILD EU collaborators, Matthias Griese

doi: 10.1136/thoraxjnl-2021-217941
Occupational lung disease
Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study

Job P van Kooten, Robert A Belderbos, Jan H von der Thüsen, Mieke J Aarts, Cornelis Verhoef, Jacobus A Burgers, Paul Baas, Arend G J Aalbers, Alexander P W M Maat, Joachim G J V Aerts, Robin Cornelissen, Eva V E Madsen

doi: 10.1136/thoraxjnl-2021-217709

February 10, 2022

Interstitial lung disease
Medical treatments for idiopathic pulmonary fibrosis: a systematic review and network meta-analysis

Tyler Pitre, Jasmine Mah, Wryan Helmeczi, Muhammad Faran Khalid, Sonya Cui, Melanie Zhang, Renata Husnudinov, Johnny Su, Laura Banfield, Brent Guy, Jade Coyne, Ciaran Scallan, Martin RJ Kolb, Aaron Jones, Dena Zeraatkar

doi: 10.1136/thoraxjnl-2021-217976

February 07, 2022

Asthma
Effects of switching from a metered dose inhaler to a dry powder inhaler on climate emissions and asthma control: post-hoc analysis

Ashley Woodcock, Christer Janson, Jamie Rees, Lucy Frith, Magnus Löfdahl, Alison Moore, Martin Hedberg, David Leather

doi: 10.1136/thoraxjnl-2021-218088

February 02, 2022

Pleural disease
Diagnostic sensitivity of pleural fluid cytology in malignant pleural effusions: systematic review and meta-analysis

Shayan Kassirian, Stephanie N Hinton, Sean Cuninghame, Rushil Chaudhary, Alla Iansavitchene, Kayvan Amjadi, Inderdeep Dhaliwal, Cady Zeman-Pocrnich, Michael A Mitchell

doi: 10.1136/thoraxjnl-2021-217959
Pleural disease
Fully automated volumetric measurement of malignant pleural mesothelioma by deep learning AI: validation and comparison with modified RECIST response criteria

Andrew C Kidd, Owen Anderson, Gordon W Cowell, Alexander J Weir, Jeremy P Voisey, Matthew Evison, Selina Tsim, Keith A Goatman, Kevin G Blyth

doi: 10.1136/thoraxjnl-2021-217808

January 27, 2022

Critical care
Altered distribution, activation and increased IL-17 production of mucosal-associated invariant T cells in patients with acute respiratory distress syndrome

Tae-Ok Kim, Ki-Jeong Park, Young-Nan Cho, Hye-Mi Jin, Young-Goun Jo, Hyo Shin Kim, Jae Kyun Ju, Hong-Joon Shin, Bo-Gun Kho, Seung-Jung Kee, Yong-Wook Park

doi: 10.1136/thoraxjnl-2021-217724

January 26, 2022

Occupational lung disease
Lifetime occupational exposures and chronic obstructive pulmonary disease risk in the UK Biobank cohort

Sara De Matteis, Debbie Jarvis, Lucy Darnton, Dario Consonni, Hans Kromhout, Sally Hutchings, Steven S Sadhra, David Fishwick, Roel Vermeulen, Lesley Rushton, Paul Cullinan

doi: 10.1136/thoraxjnl-2020-216523

January 24, 2022

Respiratory epidemiology
Patients with presumed tuberculosis in sub-Saharan Africa that are not diagnosed with tuberculosis: a systematic review and meta-analysis

Shamanthi Jayasooriya, Francesca Dimambro-Denson, Claire Beecroft, Julie Balen, Babatunde Awokola, Caroline Mitchell, Beate Kampmann, Fiona Campbell, Pete Dodd, Kevin Mortimer

doi: 10.1136/thoraxjnl-2021-217663

January 21, 2022

Sleep
Neural ventilatory drive decline as a predominant mechanism of obstructive sleep apnoea events

Laura K Gell, Daniel Vena, Raichel M Alex, Ali Azarbarzin, Nicole Calianese, Lauren B Hess, Luigi Taranto-Montemurro, David P White, Andrew Wellman, Scott A Sands

doi: 10.1136/thoraxjnl-2021-217756
Editorial
Being obstructive in sleep apnoea: more of a drive than a load problem?

Yuan-Ming Luo, Michael I Polkey

doi: 10.1136/thoraxjnl-2021-218437

January 19, 2022

Asthma
Height and bone mineral content after inhaled corticosteroid use in the first 6 years of life

Asja Kunøe, Astrid Sevelsted, Bo L K Chawes, Jakob Stokholm, Martin Krakauer, Klaus Bønnelykke, Hans Bisgaard

doi: 10.1136/thoraxjnl-2020-216755

January 13, 2022

Respiratory infection
Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study

Virve I Enne, Alp Aydin, Rossella Baldan, Dewi R Owen, Hollian Richardson, Federico Ricciardi, Charlotte Russell, Brenda O Nomamiukor-Ikeji, Ann-Marie Swart, Juliet High, Antony Colles, Julie Barber, Vanya Gant, David M Livermore, Justin O’Grady INHALE WP1 Study Group

doi: 10.1136/thoraxjnl-2021-216990

January 11, 2022

Respiratory infection
Bacterial biofilms predominate in both acute and chronic human lung infections

Mette Kolpen, Kasper Nørskov Kragh, Juan Barraza Enciso, Daniel Faurholt-Jepsen, Birgitte Lindegaard, Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Pernille Ravn, Inger Hee Mabuza Mathiesen, Alexandra Gabriella Gheorge, Frederik Boëtius Hertz, Tavs Qvist, Marvin Whiteley, Peter Østrup Jensen, Thomas Bjarnsholt

doi: 10.1136/thoraxjnl-2021-217576

January 10, 2022

Environmental exposure
Secondhand nicotine vaping at home and respiratory symptoms in young adults

Talat Islam, Jessica Braymiller, Sandrah P Eckel, Feifei Liu, Alayna P Tackett, Meghan E Rebuli, Jessica Barrington-Trimis, Rob McConnell

doi: 10.1136/thoraxjnl-2021-217041
Editorial
Beware, vaping e-cigarettes around children is adversely impacting their lung health

Ana Lucia Fuentes, Laura E Crotty Alexander

doi: 10.1136/thoraxjnl-2021-218168

January 07, 2022

Tuberculosis
High-dose rifamycins in the treatment of TB: a systematic review and meta-analysis

Omri A Arbiv, JeongMin M Kim, Marie Yan, Kamila Romanowski, Jonathon R Campbell, Anete Trajman, Leyla Asadi, Federica Fregonese, Nicholas Winters, Dick Menzies, James C Johnston

doi: 10.1136/thoraxjnl-2020-216497
Editorial
Does impaired respiratory function lead to sudden cardiac death?

Rebecca F D'Cruz, Georgios Kaltsakas

doi: 10.1136/thoraxjnl-2021-218296

December 23, 2021

Asthma
Plasma adiponectin and risk of asthma: observational analysis, genetic Mendelian randomisation and meta-analysis

Maria Booth Nielsen, Børge G Nordestgaard, Marianne Benn, Yunus Çolak

doi: 10.1136/thoraxjnl-2021-217675
Interstitial lung disease
Relative environmental and social disadvantage in patients with idiopathic pulmonary fibrosis

Na'ama Avitzur, Elizabeth M Noth, Mubasiru Lamidi, Steven D Nathan, Harold R Collard, Alison M DeDent, Neeta Thakur, Kerri A Johannson

doi: 10.1136/thoraxjnl-2021-217652

December 22, 2021

Tuberculosis
Respiratory symptoms and lung function in patients treated for pulmonary tuberculosis in Malawi: a prospective cohort study

Rebecca Nightingale, Beatrice Chinoko, Maia Lesosky, Sarah J Rylance, Bright Mnesa, Ndaziona Peter Kwanjo Banda, Elizabeth Joekes, Stephen Bertel Squire, Kevin Mortimer, Jamilah Meghji, Jamie Rylance

doi: 10.1136/thoraxjnl-2021-217190
Editorial
Improving the lives of individuals with chronic respiratory disease: the need for innovation

Linda Nici

doi: 10.1136/thoraxjnl-2021-218318

December 09, 2021

Lung cancer
Comparative accuracy and cost-effectiveness of dynamic contrast-enhanced CT and positron emission tomography in the characterisation of solitary pulmonary nodules

Fiona J Gilbert, Scott Harris, Kenneth A Miles, Jonathan R Weir-McCall, Nagmi R Qureshi, Robert Campbell Rintoul, Sabina Dizdarevic, Lucy Pike, Donald Sinclair, Andrew Shah, Rosemary Eaton, Jeremy Jones, Andrew Clegg, Valerio Benedetto, James Hill, Andrew Cook, Dimitrios Tzelis, Luke Vale, Lucy Brindle, Jackie Madden, Kelly Cozens, Louisa Little, Kathrin Eichhorst, Patricia Moate, Chris McClement, Charles Peebles, Anindo Banerjee, Sai Han, Fat-Wui Poon, Ashley M Groves, Lutfi Kurban, Anthony Frew, Matthew E J Callister, Phil A Crosbie, Fergus Vincent Gleeson, Kavitasagary Karunasaagarar, Osei Kankam, Steve George

doi: 10.1136/thoraxjnl-2021-216948

December 07, 2021

Tuberculosis
Performance of QuantiFERON-TB Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study

Aleix Soler-Garcia, Anna Gamell, Tomàs Pérez-Porcuna, Antonio Soriano-Arandes, Begoña Santiago, Teresa Tórtola, María Jesús Ruiz-Serrano, José Javier Korta Murua, Matilde Bustillo-Alonso, María Isabel Garrote-Llanos, Paula Rodríguez-Molino, Ana Isabel Piqueras, Alfredo Tagarro, Manuel Monsonís, Marc Tebruegge, Antoni Noguera-Julian On behalf of the QFT-Plus Study Group of the Spanish Pediatric TB Research Network

doi: 10.1136/thoraxjnl-2021-217592
Tuberculosis
Effect modification of greenness on PM_2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort

Erjia Ge, Jianhui Gao, Xiaolin Wei, Zhoupeng Ren, Jing Wei, Xin Liu, Xiaomeng Wang, Jieming Zhong, Jingru Lu, Xiaomei Tian, Fangrong Fei, Bin Chen, Xiaolin Wang, Ying Peng, Ming Luo, Juan Lei

doi: 10.1136/thoraxjnl-2020-216819
Asthma
Effect of CRTH2 antagonism on the response to experimental rhinovirus infection in asthma: a pilot randomised controlled trial

Hugo Farne, Nicholas Glanville, Nicholas Johnson, Tata Kebadze, Julia Aniscenko, Eteri Regis, Jie Zhu, Maria-Belen Trujillo-Torralbo, Onn Min Kon, Patrick Mallia, A Toby Prevost, Michael R Edwards, Sebastian L Johnston, Aran Singanayagam, David J Jackson

doi: 10.1136/thoraxjnl-2021-217429

December 06, 2021

Chronic obstructive pulmonary disease
Telerehabilitation for chronic respiratory disease: a randomised controlled equivalence trial

Narelle S Cox, Christine F McDonald, Ajay Mahal, Jennifer A Alison, Richard Wootton, Catherine J Hill, Paolo Zanaboni, Paul O'Halloran, Janet Bondarenko, Heather Macdonald, Kathryn Barker, Hayley Crute, Christie Mellerick, Bruna Wageck, Helen Boursinos, Aroub Lahham, Amanda Nichols, Pawel Czupryn, Monique Corbett, Emma Handley, Angela T Burge, Anne E Holland

doi: 10.1136/thoraxjnl-2021-216934
Asthma
Disadvantage in early-life and persistent asthma in adolescents: a UK cohort study

Hanna Creese, Eric Lai, Kate Mason, Daniela K Schlüter, Sejal Saglani, David Taylor-Robinson, Sonia Saxena

doi: 10.1136/thoraxjnl-2021-217312

December 03, 2021

Paediatric lung disease
Higher exhaled nitric oxide at 6 weeks of age is associated with less bronchiolitis and wheeze in the first 12 months of age

Carla Rebeca Da Silva Sena, Ediane de Queiroz Andrade, Patricia de Gouveia Belinelo, Elizabeth Percival, Benjamin Prangemeier, Christopher O'Donoghue, Sandrine Terry, Tanya Burke, William Gunning, Vanessa E Murphy, Paul D Robinson, Peter D Sly, Peter G Gibson, Adam M Collison, Joerg Mattes

doi: 10.1136/thoraxjnl-2021-217299

December 01, 2021

Images in Thorax
Reversible bronchiectasis
Free

Chuan Tai Foo, Sumit Karia, Jurgen Herre

doi: 10.1136/thoraxjnl-2021-217548
Lung cancer
Tumour-infiltrating bystander CD8⁺ T cells activated by IL-15 contribute to tumour control in non-small cell lung cancer

Galam Leem, Minwoo Jeon, Kun Woo Kim, Seongju Jeong, Seong Jin Choi, Yong Joon Lee, Eui-Soon Kim, Jae-Ik Lee, Seung Yeon Ha, Su-Hyung Park, Hyo Sup Shim, Jin Gu Lee, Shin Myung Kang, Eui-Cheol Shin

doi: 10.1136/thoraxjnl-2021-217001
Chronic obstructive pulmonary disease
Dietary nitrate supplementation to enhance exercise capacity in hypoxic COPD: EDEN-OX, a double-blind, placebo-controlled, randomised cross-over study

Matthew J Pavitt, Adam Lewis, Sara C Buttery, Bernadette O Fernandez, Monika Mikus-Lelinska, Winston A S Banya, Martin Feelisch, Michael I Polkey, Nicholas S Hopkinson

doi: 10.1136/thoraxjnl-2021-217147
Skeletal muscle
CT pectoralis muscle area is associated with DXA lean mass and correlates with emphysema progression in a tobacco-exposed cohort

Michael Emmet O'Brien, Richard H Zou, Nathan Hyre, Joseph K Leader, Carl R Fuhrman, Frank C Sciurba, Mehdi Nouraie, Jessica Bon

doi: 10.1136/thoraxjnl-2021-217710
Chronic obstructive pulmonary disease
Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies

Katarina Kamenar, Shakir Hossen, Akshay N Gupte, Trishul Siddharthan, Suzanne Pollard, Muhammad Chowdhury, Adolfo L Rubinstein, Vilma E Irazola, Laura Gutierrez, J Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, Bruce Kirenga, Rupert C Jones, Frederik van Gemert, Robert A Wise, William Checkley

doi: 10.1136/thoraxjnl-2020-216500
Editorial
TB and COPD in low-income settings: a collision of old foes

Jamilah Meghji, Kevin Mortimer, Stellah Mpangama

doi: 10.1136/thoraxjnl-2021-218220

November 30, 2021

Respiratory infection
Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK)
Free

Hayley Holt, Mohammad Talaei, Matthew Greenig, Dominik Zenner, Jane Symons, Clare Relton, Katherine S Young, Molly R Davies, Katherine N Thompson, Jed Ashman, Sultan Saeed Rajpoot, Ahmed Ali Kayyale, Sarah El Rifai, Philippa J Lloyd, David Jolliffe, Olivia Timmis, Sarah Finer, Stamatina Iliodromiti, Alec Miners, Nicholas S Hopkinson, Bodrul Alam, Graham Lloyd-Jones, Thomas Dietrich, Iain Chapple, Paul E Pfeffer, David McCoy, Gwyneth Davies, Ronan A Lyons, Christopher Griffiths, Frank Kee, Aziz Sheikh, Gerome Breen, Seif O Shaheen, Adrian R Martineau

doi: 10.1136/thoraxjnl-2021-217487
Tuberculosis
A prospective longitudinal study of chronic pulmonary aspergillosis in pulmonary tuberculosis in Indonesia (APICAL)

Findra Setianingrum, Anna Rozaliyani, Robiatul Adawiyah, Ridhawati Syam, Mulyati Tugiran, Cut Yulia Indah Sari, Finny Nandipinto, Johannes Ramnath, Arief Riadi Arifin, Diah Handayani, Erlina Burhan, Martin Rumende, Retno Wahyuningsih, Riina Rautemaa-Richardson, David W Denning

doi: 10.1136/thoraxjnl-2020-216464

November 26, 2021

Chronic obstructive pulmonary disease
Benefit–harm analysis of azithromycin for the prevention of acute exacerbations of chronic obstructive pulmonary disease

Safa Ahmadian, Don D Sin, Larry Lynd, Mark Harrison, Mohsen Sadatsafavi

doi: 10.1136/thoraxjnl-2021-217962
Chronic obstructive pulmonary disease
Cost-effectiveness of domiciliary non-invasive ventilation in patients with chronic obstructive pulmonary disease

James Hall, Alice Margaret Turner, Janine Dretzke, David Moore, Sue Jowett

doi: 10.1136/thoraxjnl-2021-217463

November 24, 2021

Respiratory epidemiology
COVID-19 hospital activity and in-hospital mortality during the first and second waves of the pandemic in England: an observational study
Free

William K Gray, Annakan V Navaratnam, Jamie Day, Julia Wendon, Tim W R Briggs

doi: 10.1136/thoraxjnl-2021-218025

November 17, 2021

Bronchiectasis
Dysregulation of prostaglandins, leukotrienes and lipoxin A₄ in bronchiectasis

Pallavi Bedi, Kerstin Ziegler, Phil D Whitfield, Donald Davidson, Adriano Giorgio Rossi, Adam T Hill

doi: 10.1136/thoraxjnl-2020-216475

November 12, 2021

Sleep
Sleep-disordered breathing and ventilatory chemosensitivity in first ischaemic stroke patients: a prospective cohort study

Sébastien Baillieul, Sébastien Bailly, Olivier Detante, Sarah Alexandre, Marie Destors, Rita Clin, Marjorie Dole, Jean-Louis Pépin, Renaud Tamisier

doi: 10.1136/thoraxjnl-2021-218003

October 29, 2021

Critical care
Non-invasive ventilation versus invasive weaning in critically ill adults: a systematic review and meta-analysis

Karen E A Burns, James Stevenson, Matthew Laird, Neill K J Adhikari, Yuchong Li, Cong Lu, Xiaolin He, Wentao Wang, Zhenting Liang, Lu Chen, Haibo Zhang, Jan O Friedrich

doi: 10.1136/thoraxjnl-2021-216993

October 27, 2021

Rehabilitation
Randomised controlled trial to investigate the use of high-frequency airway oscillations as training to improve dyspnoea (TIDe) in COPD

Enya Daynes, Neil Greening, Sally J Singh

doi: 10.1136/thoraxjnl-2021-217072

October 25, 2021

Respiratory research
Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrier

Namho Kim, Gijung Kwak, Jason Rodriguez, Alessandra Livraghi-Butrico, Xinyuan Zuo, Valentina Simon, Eric Han, Siddharth Kaup Shenoy, Nikhil Pandey, Marina Mazur, Susan E Birket, Anthony Kim, Steven M Rowe, Richard Boucher, Justin Hanes, Jung Soo Suk

doi: 10.1136/thoraxjnl-2020-215185

October 16, 2021

Chronic obstructive pulmonary disease
Automatic oxygen titration versus constant oxygen flow rates during walking in COPD: a randomised controlled, double-blind, crossover trial

Tessa Schneeberger, Inga Jarosch, Daniela Leitl, Rainer Gloeckl, Wolfgang Hitzl, Clancy John Dennis, Tatjana Geyer, Carl-Peter Criée, Andreas Rembert Koczulla, Klaus Kenn

doi: 10.1136/thoraxjnl-2020-216509

October 14, 2021

Respiratory research
Metabolomic differences in lung function metrics: evidence from two cohorts

Rachel S. Kelly, Isobel D. Stewart, Haley Bayne, Priyadarshini Kachroo, Avron Spiro III, Pantel Vokonas, David Sparrow, Scott T. Weiss, Hanna M. Knihtilä, Augusto A. Litonjua, Nicholas J. Wareham, Claudia Langenberg, Jessica A. Lasky-Su

doi: 10.1136/thoraxjnl-2020-216639

September 23, 2021

Cystic fibrosis
Projecting the impact of triple CFTR modulator therapy on intravenous antibiotic requirements in cystic fibrosis using patient registry data combined with treatment effects from randomised trials

Ruth H Keogh, Rebecca Cosgriff, Eleni-Rosalina Andrinopoulou, Keith G Brownlee, Siobhán B Carr, Karla Diaz-Ordaz, Emily Granger, Nicholas P Jewell, Alex Lewin, Clemence Leyrat, Daniela K Schlüter, Maarten van Smeden, Rhonda D Szczesniak, Gary J Connett

doi: 10.1136/thoraxjnl-2020-216265

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