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Online First

April 21, 2022

Respiratory infection
Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1β in Klebsiella-mediated acute respiratory distress syndrome

Li-Tzu Wang, B Linju Yen, Hsiu-Huan Wang, Ying-Yin Chao, Wei Lee, Li-Yueh Huang, Sheng-Kang Chiu, L. Kristopher Siu, Ko-Jiunn Liu, Huey-Kang Sytwu, Men-Luh Yen

doi: 10.1136/thoraxjnl-2021-217928
Chronic obstructive pulmonary disease
Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD: a randomised controlled trial

Marc Spielmanns, Rainer Gloeckl, Inga Jarosch, Daniela Leitl, Tessa Schneeberger, Tobias Boeselt, Stephan Huber, Pawandeep Kaur-Bollinger, Bernhard Ulm, Claudia Mueller, Jonas Bjoerklund, Sabine Spielmanns, Wolfram Windisch, Anna-Maria Pekacka-Egli, Andreas Rembert Koczulla

doi: 10.1136/thoraxjnl-2021-218338
Lung transplantation
Altered purine metabolism at reperfusion affects clinical outcome in lung transplantation

Cristina Baciu, Jason Shin, Michael Hsin, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu

doi: 10.1136/thoraxjnl-2021-217498
Images in Thorax
Customised Y-shaped self-expandable covered metallic stent with a dead end for the treatment of bronchopleural fistula
Free

Yahua Li, Yiyang Liu, Kewei Ren, Xinwei Han, Jianzhuang Ren

doi: 10.1136/thoraxjnl-2021-218080

April 15, 2022

Cystic fibrosis
Evaluation of clinically relevant changes in the lung clearance index in children with cystic fibrosis and healthy controls

Lucy Perrem, Sanja Stanojevic, Melinda Solomon, Hartmut Grasemann, Neil Sweezey, Valerie Waters, Don B Sanders, Stephanie D Davis, Felix Ratjen

doi: 10.1136/thoraxjnl-2021-218347

April 11, 2022

Thoracic surgery
Cytoreductive surgery with hyperthermic intrathoracic chemotherapy for malignant pleural mesothelioma: a systematic review

Alan G. Dawson, Kudzayi Kutywayo, Seid B. Mohammed, Dean A. Fennell, Apostolos Nakas

doi: 10.1136/thoraxjnl-2021-218214

April 07, 2022

Lung cancer
Selection of eligible participants for screening for lung cancer using primary care data

Emma L O'Dowd, Kevin ten Haaf, Jaspreet Kaur, Stephen W Duffy, William Hamilton, Richard B Hubbard, John K Field, Matthew EJ Callister, Sam M Janes, Harry J de Koning, Janette Rawlinson, David R Baldwin

doi: 10.1136/thoraxjnl-2021-217142
Images in Thorax
Massive colothorax secondary to intestinal pseudo-obstruction: an unusual cause of respiratory failure
Free

Benjamin Pippard, Laura Clarke, Victor Chew, Kevin Conroy, Julia Dunleavy

doi: 10.1136/thoraxjnl-2021-218282

April 05, 2022

Lung transplantation
Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction

Nicholas A Kolaitis, Ying Gao, Allison Soong, John R Greenland, Steven R Hays, Jeffrey A Golden, Aida Venado, Lorriana E Leard, Rupal J Shah, Mary Ellen Kleinhenz, Patricia P Katz, Jasleen Kukreja, Paul D Blanc, Patrick J Smith, Jonathan Paul Singer

doi: 10.1136/thoraxjnl-2021-217612

March 31, 2022

Environmental exposure
Short-term exposure to ambient air pollution and individual emergency department visits for COVID-19: a case-crossover study in Canada

Eric Lavigne, Niilo Ryti, Antonio Gasparrini, Francesco Sera, Scott Weichenthal, Hong Chen, Teresa To, Greg J Evans, Liu Sun, Aman Dheri, Lionnel Lemogo, Serge Olivier Kotchi, Dave Stieb

doi: 10.1136/thoraxjnl-2021-217602
Tuberculosis
Airflow obstruction and small airway dysfunction following pulmonary tuberculosis: a cross-sectional survey

Zhenzhen Xing, Tieying Sun, Jean-Paul Janssens, Di Chai, Weiming Liu, Yaqi Tong, Yuxia Wang, Yali Ma, Mingming Pan, Jia Cui, Chen Wang, YanFei Guo

doi: 10.1136/thoraxjnl-2021-218345

March 30, 2022

Smoking
Cigarette smoking is a secondary cause of folliculin loss

Xiuying Li, Yandong Lai, Zachary Lane, Hilary Strollo, Kazuya Tanimura, John C Sembrat, Chunbin Zou, Michael M Myerburg, Mauricio Rojas, Steven Shapiro, Yu Jiang, Toru Nyunoya

doi: 10.1136/thoraxjnl-2021-217197
Respiratory research
Cost-effectiveness of ambulatory care management of primary spontaneous pneumothorax: an open-label, randomised controlled trial

Ramon Luengo-Fernandez, Filipa Landeiro, Rob Hallifax, Najib M Rahman

doi: 10.1136/thoraxjnl-2021-218479
Asthma
Relationship between asthma and severe COVID-19: a national cohort study

Ted Dolby, Vahe Nafilyan, Ann Morgan, Constantinos Kallis, Aziz Sheikh, Jennifer K Quint

doi: 10.1136/thoraxjnl-2021-218629
Respiratory infection
Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis

Yandong Lai, Xiuying Li, Tiao Li, Xiaoyun Li, Toru Nyunoya, Kong Chen, Georgios Kitsios, Mehdi Nouraie, Yingze Zhang, Bryan J McVerry, Janet S Lee, Rama K Mallmapalli, Chunbin Zou

doi: 10.1136/thoraxjnl-2021-217526

March 25, 2022

Interstitial lung disease
Parenchymal lung abnormalities following hospitalisation for COVID-19 and viral pneumonitis: a systematic review and meta-analysis
Free

Laura Fabbri, Samuel Moss, Fasihul A Khan, Wenjie Chi, Jun Xia, Karen Robinson, Alan Robert Smyth, Gisli Jenkins, Iain Stewart

doi: 10.1136/thoraxjnl-2021-218275

March 24, 2022

Interstitial lung disease
Derivation and validation of a simple multidimensional index incorporating exercise capacity parameters for survival prediction in idiopathic pulmonary fibrosis

Abhimanyu Chandel, Jean Pastre, Solène Valery, Christopher S King, Steven D Nathan

doi: 10.1136/thoraxjnl-2021-218440
Critical care
Evaluation of a health and social care programme to improve outcomes following critical illness: a multicentre study

Philip Henderson, Tara Quasim, Martin Shaw, Pamela MacTavish, Helen Devine, Malcolm Daniel, Fiona Nicolson, Peter O’Brien, Ashley Weir, Laura Strachan, Lorraine Senior, Phil Lucie, Lynn Bollan, Jane Duffty, Lucy Hogg, Colette Ross, Malcolm Sim, Radha Sundaram, Theodore J Iwashyna, Joanne McPeake

doi: 10.1136/thoraxjnl-2021-218428

March 23, 2022

Critical care
Thoracic ultrasound influences physiotherapist’s clinical decision-making in respiratory management of critical care patients: a multicentre cohort study

Aymeric Le Neindre, Louise Hansell, Johan Wormser, Andreia Gomes Lopes, Carlos Diaz Lopez, Christophe Romanet, Gerald Choukroun, Maxime Nguyen, François Philippart, Pierre-Grégoire Guinot, Hergen Buscher, Bélaid Bouhemad, George Ntoumenopoulos

doi: 10.1136/thoraxjnl-2021-218217

March 18, 2022

Sleep
Cardiovascular outcomes in obstructive sleep apnoea and implications of clinical phenotyping on effect of CPAP treatment

Pei-Hang Xu, Daniel Y T Fong, Macy M S Lui, David C L Lam, Mary Sau Man Ip

doi: 10.1136/thoraxjnl-2021-217714

March 11, 2022

Respiratory research
Nationwide indoor smoking ban and impact on smoking behaviour and lung function: a two-population natural experiment

Alexandra Strassmann, Yunus Çolak, Miquel Serra-Burriel, Børge G Nordestgaard, Alexander Turk, Shoaib Afzal, Milo A Puhan

doi: 10.1136/thoraxjnl-2021-218436

March 02, 2022

Asthma
Long-term exposure to ambient air pollution and asthma symptom score in the CONSTANCES cohort

Marion Keirsbulck, Marine Savouré, Emeline Lequy, Jie Chen, Kees de Hoogh, Danielle Vienneau, Marcel Goldberg, Marie Zins, Nicolas Roche, Rachel Nadif, Benedicte Jacquemin

doi: 10.1136/thoraxjnl-2021-218344

February 24, 2022

Respiratory epidemiology
Respiratory and allergic outcomes among 5-year-old children exposed to pesticides

Jessica Y Islam, Jane Hoppin, Ana M Mora, Manuel E Soto-Martinez, Leonel Córdoba Gamboa, Jorge Ernesto Peñaloza Castañeda, Brian Reich, Christian Lindh, Berna van Wendel de Joode

doi: 10.1136/thoraxjnl-2021-218068

February 14, 2022

Respiratory infection
Lung directed antibody gene transfer confers protection against SARS-CoV-2 infection

Yue Du, Kamran M Miah, Omar Habib, Helena Meyer-Berg, Catriona C Conway, Mariana A Viegas, Rebecca Dean, Dwiantari Satyapertiwi, Jincun Zhao, Yanqun Wang, Nigel J Temperton, Toby P E Gamlen, Deborah R Gill, Stephen C Hyde

doi: 10.1136/thoraxjnl-2021-217650

February 11, 2022

Occupational lung disease
Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma: a population-based study

Job P van Kooten, Robert A Belderbos, Jan H von der Thüsen, Mieke J Aarts, Cornelis Verhoef, Jacobus A Burgers, Paul Baas, Arend G J Aalbers, Alexander P W M Maat, Joachim G J V Aerts, Robin Cornelissen, Eva V E Madsen

doi: 10.1136/thoraxjnl-2021-217709

February 10, 2022

Interstitial lung disease
Medical treatments for idiopathic pulmonary fibrosis: a systematic review and network meta-analysis

Tyler Pitre, Jasmine Mah, Wryan Helmeczi, Muhammad Faran Khalid, Sonya Cui, Melanie Zhang, Renata Husnudinov, Johnny Su, Laura Banfield, Brent Guy, Jade Coyne, Ciaran Scallan, Martin RJ Kolb, Aaron Jones, Dena Zeraatkar

doi: 10.1136/thoraxjnl-2021-217976

February 07, 2022

Asthma
Effects of switching from a metered dose inhaler to a dry powder inhaler on climate emissions and asthma control: post-hoc analysis

Ashley Woodcock, Christer Janson, Jamie Rees, Lucy Frith, Magnus Löfdahl, Alison Moore, Martin Hedberg, David Leather

doi: 10.1136/thoraxjnl-2021-218088

February 02, 2022

Pleural disease
Diagnostic sensitivity of pleural fluid cytology in malignant pleural effusions: systematic review and meta-analysis

Shayan Kassirian, Stephanie N Hinton, Sean Cuninghame, Rushil Chaudhary, Alla Iansavitchene, Kayvan Amjadi, Inderdeep Dhaliwal, Cady Zeman-Pocrnich, Michael A Mitchell

doi: 10.1136/thoraxjnl-2021-217959
Pleural disease
Fully automated volumetric measurement of malignant pleural mesothelioma by deep learning AI: validation and comparison with modified RECIST response criteria

Andrew C Kidd, Owen Anderson, Gordon W Cowell, Alexander J Weir, Jeremy P Voisey, Matthew Evison, Selina Tsim, Keith A Goatman, Kevin G Blyth

doi: 10.1136/thoraxjnl-2021-217808

January 27, 2022

Critical care
Altered distribution, activation and increased IL-17 production of mucosal-associated invariant T cells in patients with acute respiratory distress syndrome

Tae-Ok Kim, Ki-Jeong Park, Young-Nan Cho, Hye-Mi Jin, Young-Goun Jo, Hyo Shin Kim, Jae Kyun Ju, Hong-Joon Shin, Bo-Gun Kho, Seung-Jung Kee, Yong-Wook Park

doi: 10.1136/thoraxjnl-2021-217724

January 26, 2022

Occupational lung disease
Lifetime occupational exposures and chronic obstructive pulmonary disease risk in the UK Biobank cohort

Sara De Matteis, Debbie Jarvis, Lucy Darnton, Dario Consonni, Hans Kromhout, Sally Hutchings, Steven S Sadhra, David Fishwick, Roel Vermeulen, Lesley Rushton, Paul Cullinan

doi: 10.1136/thoraxjnl-2020-216523

January 24, 2022

Respiratory epidemiology
Patients with presumed tuberculosis in sub-Saharan Africa that are not diagnosed with tuberculosis: a systematic review and meta-analysis

Shamanthi Jayasooriya, Francesca Dimambro-Denson, Claire Beecroft, Julie Balen, Babatunde Awokola, Caroline Mitchell, Beate Kampmann, Fiona Campbell, Pete Dodd, Kevin Mortimer

doi: 10.1136/thoraxjnl-2021-217663

January 13, 2022

Respiratory infection
Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study

Virve I Enne, Alp Aydin, Rossella Baldan, Dewi R Owen, Hollian Richardson, Federico Ricciardi, Charlotte Russell, Brenda O Nomamiukor-Ikeji, Ann-Marie Swart, Juliet High, Antony Colles, Julie Barber, Vanya Gant, David M Livermore, Justin O’Grady INHALE WP1 Study Group

doi: 10.1136/thoraxjnl-2021-216990

January 11, 2022

Respiratory infection
Bacterial biofilms predominate in both acute and chronic human lung infections

Mette Kolpen, Kasper Nørskov Kragh, Juan Barraza Enciso, Daniel Faurholt-Jepsen, Birgitte Lindegaard, Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Pernille Ravn, Inger Hee Mabuza Mathiesen, Alexandra Gabriella Gheorge, Frederik Boëtius Hertz, Tavs Qvist, Marvin Whiteley, Peter Østrup Jensen, Thomas Bjarnsholt

doi: 10.1136/thoraxjnl-2021-217576

January 07, 2022

Tuberculosis
High-dose rifamycins in the treatment of TB: a systematic review and meta-analysis

Omri A Arbiv, JeongMin M Kim, Marie Yan, Kamila Romanowski, Jonathon R Campbell, Anete Trajman, Leyla Asadi, Federica Fregonese, Nicholas Winters, Dick Menzies, James C Johnston

doi: 10.1136/thoraxjnl-2020-216497

December 23, 2021

Asthma
Plasma adiponectin and risk of asthma: observational analysis, genetic Mendelian randomisation and meta-analysis

Maria Booth Nielsen, Børge G Nordestgaard, Marianne Benn, Yunus Çolak

doi: 10.1136/thoraxjnl-2021-217675
Interstitial lung disease
Relative environmental and social disadvantage in patients with idiopathic pulmonary fibrosis

Na'ama Avitzur, Elizabeth M Noth, Mubasiru Lamidi, Steven D Nathan, Harold R Collard, Alison M DeDent, Neeta Thakur, Kerri A Johannson

doi: 10.1136/thoraxjnl-2021-217652

December 22, 2021

Tuberculosis
Respiratory symptoms and lung function in patients treated for pulmonary tuberculosis in Malawi: a prospective cohort study

Rebecca Nightingale, Beatrice Chinoko, Maia Lesosky, Sarah J Rylance, Bright Mnesa, Ndaziona Peter Kwanjo Banda, Elizabeth Joekes, Stephen Bertel Squire, Kevin Mortimer, Jamilah Meghji, Jamie Rylance

doi: 10.1136/thoraxjnl-2021-217190

December 09, 2021

Lung cancer
Comparative accuracy and cost-effectiveness of dynamic contrast-enhanced CT and positron emission tomography in the characterisation of solitary pulmonary nodules

Fiona J Gilbert, Scott Harris, Kenneth A Miles, Jonathan R Weir-McCall, Nagmi R Qureshi, Robert Campbell Rintoul, Sabina Dizdarevic, Lucy Pike, Donald Sinclair, Andrew Shah, Rosemary Eaton, Jeremy Jones, Andrew Clegg, Valerio Benedetto, James Hill, Andrew Cook, Dimitrios Tzelis, Luke Vale, Lucy Brindle, Jackie Madden, Kelly Cozens, Louisa Little, Kathrin Eichhorst, Patricia Moate, Chris McClement, Charles Peebles, Anindo Banerjee, Sai Han, Fat-Wui Poon, Ashley M Groves, Lutfi Kurban, Anthony Frew, Matthew E J Callister, Phil A Crosbie, Fergus Vincent Gleeson, Kavitasagary Karunasaagarar, Osei Kankam, Steve George

doi: 10.1136/thoraxjnl-2021-216948

December 07, 2021

Tuberculosis
Performance of QuantiFERON-TB Gold Plus assays in children and adolescents at risk of tuberculosis: a cross-sectional multicentre study

Aleix Soler-Garcia, Anna Gamell, Tomàs Pérez-Porcuna, Antonio Soriano-Arandes, Begoña Santiago, Teresa Tórtola, María Jesús Ruiz-Serrano, José Javier Korta Murua, Matilde Bustillo-Alonso, María Isabel Garrote-Llanos, Paula Rodríguez-Molino, Ana Isabel Piqueras, Alfredo Tagarro, Manuel Monsonís, Marc Tebruegge, Antoni Noguera-Julian On behalf of the QFT-Plus Study Group of the Spanish Pediatric TB Research Network

doi: 10.1136/thoraxjnl-2021-217592
Tuberculosis
Effect modification of greenness on PM_2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort

Erjia Ge, Jianhui Gao, Xiaolin Wei, Zhoupeng Ren, Jing Wei, Xin Liu, Xiaomeng Wang, Jieming Zhong, Jingru Lu, Xiaomei Tian, Fangrong Fei, Bin Chen, Xiaolin Wang, Ying Peng, Ming Luo, Juan Lei

doi: 10.1136/thoraxjnl-2020-216819

December 06, 2021

Asthma
Disadvantage in early-life and persistent asthma in adolescents: a UK cohort study

Hanna Creese, Eric Lai, Kate Mason, Daniela K Schlüter, Sejal Saglani, David Taylor-Robinson, Sonia Saxena

doi: 10.1136/thoraxjnl-2021-217312

December 03, 2021

Paediatric lung disease
Higher exhaled nitric oxide at 6 weeks of age is associated with less bronchiolitis and wheeze in the first 12 months of age

Carla Rebeca Da Silva Sena, Ediane de Queiroz Andrade, Patricia de Gouveia Belinelo, Elizabeth Percival, Benjamin Prangemeier, Christopher O'Donoghue, Sandrine Terry, Tanya Burke, William Gunning, Vanessa E Murphy, Paul D Robinson, Peter D Sly, Peter G Gibson, Adam M Collison, Joerg Mattes

doi: 10.1136/thoraxjnl-2021-217299

December 01, 2021

Chronic obstructive pulmonary disease
Dietary nitrate supplementation to enhance exercise capacity in hypoxic COPD: EDEN-OX, a double-blind, placebo-controlled, randomised cross-over study

Matthew J Pavitt, Adam Lewis, Sara C Buttery, Bernadette O Fernandez, Monika Mikus-Lelinska, Winston A S Banya, Martin Feelisch, Michael I Polkey, Nicholas S Hopkinson

doi: 10.1136/thoraxjnl-2021-217147
Skeletal muscle
CT pectoralis muscle area is associated with DXA lean mass and correlates with emphysema progression in a tobacco-exposed cohort

Michael Emmet O'Brien, Richard H Zou, Nathan Hyre, Joseph K Leader, Carl R Fuhrman, Frank C Sciurba, Mehdi Nouraie, Jessica Bon

doi: 10.1136/thoraxjnl-2021-217710
Editorial
TB and COPD in low-income settings: a collision of old foes

Jamilah Meghji, Kevin Mortimer, Stellah Mpangama

doi: 10.1136/thoraxjnl-2021-218220
Chronic obstructive pulmonary disease
Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies

Katarina Kamenar, Shakir Hossen, Akshay N Gupte, Trishul Siddharthan, Suzanne Pollard, Muhammad Chowdhury, Adolfo L Rubinstein, Vilma E Irazola, Laura Gutierrez, J Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, Bruce Kirenga, Rupert C Jones, Frederik van Gemert, Robert A Wise, William Checkley

doi: 10.1136/thoraxjnl-2020-216500

November 30, 2021

Respiratory infection
Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK)
Free

Hayley Holt, Mohammad Talaei, Matthew Greenig, Dominik Zenner, Jane Symons, Clare Relton, Katherine S Young, Molly R Davies, Katherine N Thompson, Jed Ashman, Sultan Saeed Rajpoot, Ahmed Ali Kayyale, Sarah El Rifai, Philippa J Lloyd, David Jolliffe, Olivia Timmis, Sarah Finer, Stamatina Iliodromiti, Alec Miners, Nicholas S Hopkinson, Bodrul Alam, Graham Lloyd-Jones, Thomas Dietrich, Iain Chapple, Paul E Pfeffer, David McCoy, Gwyneth Davies, Ronan A Lyons, Christopher Griffiths, Frank Kee, Aziz Sheikh, Gerome Breen, Seif O Shaheen, Adrian R Martineau

doi: 10.1136/thoraxjnl-2021-217487

November 26, 2021

Chronic obstructive pulmonary disease
Benefit–harm analysis of azithromycin for the prevention of acute exacerbations of chronic obstructive pulmonary disease

Safa Ahmadian, Don D Sin, Larry Lynd, Mark Harrison, Mohsen Sadatsafavi

doi: 10.1136/thoraxjnl-2021-217962
Chronic obstructive pulmonary disease
Cost-effectiveness of domiciliary non-invasive ventilation in patients with chronic obstructive pulmonary disease

James Hall, Alice Margaret Turner, Janine Dretzke, David Moore, Sue Jowett

doi: 10.1136/thoraxjnl-2021-217463

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