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Online First

July 26, 2021

Rehabilitation
A telerehabilitation programme in post-discharge COVID-19 patients (TERECO): a randomised controlled trial

Jian'an Li, Wenguang Xia, Chao Zhan, Shouguo Liu, Zhifei Yin, Jiayue Wang, Yufei Chong, Chanjuan Zheng, Xiaoming Fang, Wei Cheng, Jan D Reinhardt

doi: 10.1136/thoraxjnl-2021-217382

July 23, 2021

Editorial
Central sleep apnoea in heart failure: one size does not fit all

Winfried J Randerath, Michael Arzt

doi: 10.1136/thoraxjnl-2021-217694
Paediatric lung disease
Association of the dysfunctional placentation endotype of prematurity with bronchopulmonary dysplasia: a systematic review, meta-analysis and meta-regression

Maria Pierro, Eduardo Villamor-Martinez, Elke van Westering-Kroon, Maria Alvarez-Fuente, Steven H Abman, Eduardo Villamor

doi: 10.1136/thoraxjnl-2020-216485

July 22, 2021

Brief communication
Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults

Mark J Ponsford, Rhys Jefferies, Chris Davies, Daniel Farewell, Ian R Humphreys, Stephen Jolles, Sara Fairbairn, Keir Lewis, Daniel Menzies, Amit Benjamin, Favas Thaivalappil, Chris Williams, Simon M Barry

doi: 10.1136/thoraxjnl-2021-216964
Cystic fibrosis
Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis

Alex R Horsley, John Belcher, Katie Bayfield, Brooke Bianco, Steve Cunningham, Catherine Fullwood, Andrew Jones, Anna Shawcross, Jaclyn A Smith, Anirban Maitra, Francis J Gilchrist

doi: 10.1136/thoraxjnl-2021-216928
Respiratory epidemiology
Associations of ultrafine and fine particles with childhood emergency room visits for respiratory diseases in a megacity

Jiakun Fang, Xiaoming Song, Hongbing Xu, Rongshan Wu, Jing Song, Yunfei Xie, Xin Xu, Yueping Zeng, Tong Wang, Yutong Zhu, Ningman Yuan, Jinzhu Jia, Baoping Xu, Wei Huang

doi: 10.1136/thoraxjnl-2021-217017

July 19, 2021

Lung cancer
International differences in lung cancer survival by sex, histological type and stage at diagnosis: an ICBP SURVMARK-2 Study

Marzieh Araghi, Miranda Fidler-Benaoudia, Melina Arnold, Mark Rutherford, Aude Bardot, Jacques Ferlay, Oliver Bucher, Prithwish De, Gerda Engholm, Anna Gavin, Serena Kozie, Alana Little, Bjørn Møller, Nathalie St Jacques, Hanna Tervonen, Paul Walsh, Ryan Woods, Dianne L O'Connell, David Baldwin, Mark Elwood, Sabine Siesling, Freddie Bray, Isabelle Soerjomataram, ICBP SURVMARK-2 Local Leads, ICBP SURVMARK-2 Academic Reference Group ICBP Clinical Committee–Lung

doi: 10.1136/thoraxjnl-2020-216555

July 16, 2021

Chronic obstructive pulmonary disease
Does pay-for-performance improve patient outcomes in acute exacerbation of COPD admissions?

Philip W Stone, Alexander Adamson, John R Hurst, C Michael Roberts, Jennifer K Quint

doi: 10.1136/thoraxjnl-2021-216880
Interstitial lung disease
Peripheral blood leucocyte telomere length is associated with progression of interstitial lung disease in systemic sclerosis

Shuo Liu, Melody P Chung, Brett Ley, Sarah French, Brett M Elicker, David F Fiorentino, Lorinda S Chung, Francesco Boin, Paul J Wolters

doi: 10.1136/thoraxjnl-2020-215918
Interstitial lung disease
Prospective nationwide multicentre cohort study of the clinical significance of autoimmune features in idiopathic interstitial pneumonias

Noriyuki Enomoto, Sakae Homma, Naohiko Inase, Yasuhiro Kondoh, Takeshi Saraya, Hajime Takizawa, Yoshikazu Inoue, Hiroshi Ishii, Yoshio Taguchi, Shinyu Izumi, Yasuhiko Yamano, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Koshi Yokomura, Shiro Imokawa, Naoki Koshimizu, Takehisa Sano, Taisuke Akamatsu, Hiroshi Mukae, Motoyasu Kato, Naoki Hamada, Hirofumi Chiba, Shinobu Akagawa, Shigeo Muro, Hironori Uruga, Hiroyuki Matsuda, Yusuke Kaida, Miho Kanai, Kazutaka Mori, Masafumi Masuda, Hironao Hozumi, Tomoyuki Fujisawa, Yutaro Nakamura, Noriyoshi Ogawa, Takafumi Suda

doi: 10.1136/thoraxjnl-2020-216263
Tuberculosis
Effect of quitting smoking on health outcomes during treatment for tuberculosis: secondary analysis of the TB & Tobacco Trial

Kamran Siddiqi, Ada Keding, Anna-Marie Marshall, Omara Dogar, Jinshuo Li, Rumana Huque, Razia Fatima, Amina Khan, Helen Elsey, Rhian Gabe, Daniel Kotz, Aziz Sheikh

doi: 10.1136/thoraxjnl-2020-215926

July 15, 2021

Editorial
Go with the flow? High flow nasal cannula for bronchoscopy

Prema Nanavaty, David J Feller-Kopman

doi: 10.1136/thoraxjnl-2021-217450

July 12, 2021

Editorial
ARDS subphenotypes: searching for Rorschach among the roentgenograms?

Andrew Conway Morris, Katharina Kohler, Manu Shankar-Hari

doi: 10.1136/thoraxjnl-2021-217428
Critical care
Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study

Pratik Sinha, Kevin L Delucchi, Yue Chen, Hanjing Zhuo, Jason Abbott, Chunxue Wang, Nancy Wickersham, J Brennan McNeil, Alejandra Jauregui, Serena Ke, Kathryn Vessel, Antonio Gomez, Carolyn M Hendrickson, Kirsten N Kangelaris, Aartik Sarma, Aleksandra Leligdowicz, Kathleen D Liu, Michael A Matthay, Lorraine B Ware, Carolyn S Calfee

doi: 10.1136/thoraxjnl-2021-217158

July 08, 2021

Images in Thorax
COVID-19 pneumonitis and cystic lung disease, pneumothorax and pneumomediastinum
Free

Serenydd Everden, Irfan Zaki, Gareth Trevelyan, James Briggs

doi: 10.1136/thoraxjnl-2021-217390

July 06, 2021

Sleep
Adaptive servo ventilation for sleep apnoea in heart failure: the FACE study 3-month data

Renaud Tamisier, Thibaud Damy, Sebastien Bailly, Jean-Marc Davy, Johan Verbraecken, Florent Lavergne, Alain Palot, Frederic Goutorbe, Marie-Pia d'Ortho, Jean Louis Pépin FACE study investigators

doi: 10.1136/thoraxjnl-2021-217205

July 05, 2021

Respiratory infection
Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data

Pontus Hedberg, John Karlsson Valik, Suzanne van der Werff, Hideyuki Tanushi, Ana Requena Mendez, Fredrik Granath, Max Bell, Johan Mårtensson, Robert Dyrdak, Olof Hertting, Anna Färnert, Anders Ternhag, Pontus Naucler

doi: 10.1136/thoraxjnl-2021-216949
Interstitial lung disease
Potential for inhibition of checkpoint kinases 1/2 in pulmonary fibrosis and secondary pulmonary hypertension

Wen-Hui Wu, Sébastien Bonnet, Tsukasa Shimauchi, Victoria Toro, Yann Grobs, Charlotte Romanet, Alice Bourgeois, Geraldine Vitry, Junichi Omura, Eve Tremblay, Valerie Nadeau, Mark Orcholski, Sandra Breuils-Bonnet, Sandra Martineau, Pasquale Ferraro, Francois Potus, Roxane Paulin, Steeve Provencher, Olivier Boucherat

doi: 10.1136/thoraxjnl-2021-217377
Interstitial lung disease
Lung transplantation for acute exacerbation of interstitial lung disease

Mwelwa Chizinga, Tiago N Machuca, Abbas Shahmohammadi, Divya C Patel, Ayoub Innabi, Bashar Alzghoul, Vanessa Scheuble, Mauricio Pipkin, Borna Mehrad, Andres Pelaez, Christine Lin, Diana Gomez- Manjarres

doi: 10.1136/thoraxjnl-2020-215681
Chronic obstructive pulmonary disease
Six-week behaviour change intervention to reduce sedentary behaviour in people with chronic obstructive pulmonary disease: a randomised controlled trial

Sonia Wing Mei Cheng, Jennifer Alison, Emmanuel Stamatakis, Sarah Dennis, Renae McNamara, Lissa Spencer, Zoe McKeough

doi: 10.1136/thoraxjnl-2020-214885

July 02, 2021

Cystic fibrosis
Lung function in children with cystic fibrosis in the USA and UK: a comparative longitudinal analysis of national registry data

Daniela K Schlüter, Josh S Ostrenga, Siobhán B Carr, Aliza K Fink, Albert Faro, Rhonda D Szczesniak, Ruth H Keogh, Susan C Charman, Bruce C Marshall, Christopher H Goss, David Taylor-Robinson

doi: 10.1136/thoraxjnl-2021-216849
Brief communication
Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx)

Pouline MP van Oort, Tamara M Nijsen, Iain R White, Hugo H Knobel, Timothy Felton, Nicholas Rattray, Oluwasola Lawal, Murtaza Bulut, Waqar Ahmed, Antonio Artigas, Pedro R Povoa, Ignacio Martin-Loeches, Hans Weda, Royston Goodacre, Marcus J Schultz, Paul M Dark, Stephen J Fowler, Lieuwe D Bos on behalf of the BreathDx Consortium

doi: 10.1136/thoraxjnl-2021-217362

June 28, 2021

Brief communication
Prognostic accuracy of a peripheral blood transcriptome signature in chronic hypersensitivity pneumonitis

Evans R Fernández Pérez, Laura D Harmacek, Brian P O'Connor, Thomas Danhorn, Brian Vestal, Lisa A Maier, Tilman L Koelsch, Sonia M Leach

doi: 10.1136/thoraxjnl-2020-214790

June 25, 2021

Lung cancer
Bronchoscopic needle-based confocal laser endomicroscopy (nCLE) as a real-time detection tool for peripheral lung cancer

Tess Kramer, Lizzy Wijmans, Martijn de Bruin, Ton van Leeuwen, Teodora Radonic, Peter Bonta, Jouke T Annema

doi: 10.1136/thoraxjnl-2021-216885
Respiratory infection
Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients

Anaïs Hérivaux, Jesse R Willis, Toine Mercier, Katrien Lagrou, Samuel M Gonçalves, Relber A Gonçales, Johan Maertens, Agostinho Carvalho, Toni Gabaldón, Cristina Cunha

doi: 10.1136/thoraxjnl-2020-216179

June 24, 2021

Chronic obstructive pulmonary disease
Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains

Auyon J Ghosh, Aabida Saferali, Sool Lee, Robert Chase, Matthew Moll, Jarrett Morrow, Jeong Yun, Peter J Castaldi, Craig P Hersh

doi: 10.1136/thoraxjnl-2020-216401
Images in Thorax
Evolutive diaphragmatic lesions causing recurrent catamenial pneumothorax

Céline Forster, Charles Bénière, Justine Lattion, Jean Yannis Perentes, Michel Christodoulou

doi: 10.1136/thoraxjnl-2021-217044

June 21, 2021

Respiratory epidemiology
Impact of lung function on cardiovascular diseases and cardiovascular risk factors: a two sample bidirectional Mendelian randomisation study

Shiu Lun Au Yeung, Maria Carolina Borges, Debbie A Lawlor, C Mary Schooling

doi: 10.1136/thoraxjnl-2020-215600

June 18, 2021

Brief communication
Combining clinical, radiological and genetic approaches to pneumothorax management

Hannah L Grimes, Simon Holden, Judith Babar, Sumit Karia, Maria TA Wetscherek, Allanah Barker, Jurgen Herre, Martin D Knolle, Eamonn R Maher, Genomics England Research Consortium, Stefan John Marciniak

doi: 10.1136/thoraxjnl-2021-217210
Brief communication
Effects of tobacco smoking on recurrent hospitalisation with pneumonia: a population-based cohort study

Vadsala Baskaran, Wei Shen Lim, Tricia M McKeever

doi: 10.1136/thoraxjnl-2020-216494

June 14, 2021

Respiratory epidemiology
Breathlessness across generations: results from the RHINESSA generation study

Magnus Ekström, Ane Johannessen, Michael J Abramson, Bryndis Benediktsdottir, Karl Franklin, Thorarinn Gislason, Francisco Gómez Real, Mathias Holm, Christer Janson, Rain Jogi, Adrian Lowe, Andrei Malinovschi, Jesús Martínez-Moratalla, Anna Oudin, José Luis Sánchez-Ramos, Vivi Schlünssen, Cecilie Svanes

doi: 10.1136/thoraxjnl-2021-217271
Brief communication
Diffuse cystic lung disease in sickle cell anaemia: a series of 22 cases and a case–control study

Fatma Kort, Anoosha Habibi, Francois Lionnet, Marie-France Carette, Antoine Parrot, Laurent Savale, Hilario Nunes, Bernard Maitre, Frederic Schlemmer, Jean-Marc Naccache

doi: 10.1136/thoraxjnl-2020-216826

June 10, 2021

Critical care
Six-month and 12-month patient outcomes based on inflammatory subphenotypes in sepsis-associated ARDS: secondary analysis of SAILS-ALTOS trial

Mohamed D Hashem, Ramona O Hopkins, Elizabeth Colantuoni, Victor D Dinglas, Pratik Sinha, Lisa Aronson Friedman, Peter E Morris, James C Jackson, Catherine L Hough, Carolyn S Calfee, Dale M Needham

doi: 10.1136/thoraxjnl-2020-216613

May 27, 2021

Critical care
RAND appropriateness panel to determine the applicability of UK guidelines on the management of acute respiratory distress syndrome (ARDS) and other strategies in the context of the COVID-19 pandemic
Free

Mark Griffiths, Susanna Meade, Charlotte Summers, Daniel Francis McAuley, Alastair Proudfoot, Marta Montero Baladia, Paul M Dark, Kate Diomede, Simon J Finney, Lui G Forni, Chris Meadows, Ian A Naldrett, Brijesh Patel, Gavin D Perkins, Mark A Samaan, Laurence Sharifi, Ganesh Suntharalingam, Nicholas T Tarmey, Harriet F Young, Matt P Wise, Peter M Irving

doi: 10.1136/thoraxjnl-2021-216904

May 13, 2021

State of the art review
Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease

Sebastian T Lugg, Aaron Scott, Dhruv Parekh, Babu Naidu, David R Thickett

doi: 10.1136/thoraxjnl-2020-216296
Brief communication
Novel recessive locus for body mass index in childhood asthma

Sanghun Lee, Jessica Lasky-Su, Sungho Won, Cecelia Laurie, Juan Carlos Celedón, Christoph Lange, Scott Weiss, Julian Hecker

doi: 10.1136/thoraxjnl-2020-215742
Brief communication
Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length

Claire F McGroder, David Zhang, Mohammad A Choudhury, Mary M Salvatore, Belinda M D'Souza, Eric A Hoffman, Ying Wei, Matthew R Baldwin, Christine Kim Garcia

doi: 10.1136/thoraxjnl-2021-217031
State of the art review
Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis

Katie J Bayfield, Tonia A Douglas, Tim Rosenow, Jane C Davies, Stuart J Elborn, Marcus Mall, Anthony Paproki, Felix Ratjen, Peter D Sly, Alan R Smyth, Stephen Stick, Claire E Wainwright, Paul D Robinson

doi: 10.1136/thoraxjnl-2020-216085
Critical care
Association of imbalance between job workload and functional ability with return to work in ARDS survivors

Han Su, Ramona O Hopkins, Biren B Kamdar, Susanne May, Victor D Dinglas, Kurt L Johnson, Megan Hosey, Catherine L Hough, Dale M Needham, Hilaire J Thompson

doi: 10.1136/thoraxjnl-2020-216586

May 11, 2021

Brief communication
Chronic airflow obstruction and ambient particulate air pollution

Andre F S Amaral, Peter G J Burney, Jaymini Patel, Cosetta Minelli, Filip Mejza, David M Mannino, Terence A R Seemungal, Padukudru Anand Mahesh, Li Cher Lo, Christer Janson, Sanjay Juvekar, Meriam Denguezli, Imed Harrabi, Emiel F M Wouters, Hamid Cherkaski, Kevin Mortimer, Rain Jogi, Eric D Bateman, Elaine Fuertes, Mohammed Al Ghobain, Wan Tan, Daniel O Obaseki, Asma El Sony, Michael Studnicka, Althea Aquart-Stewart, Parvaiz Koul, Herve Lawin, Asaad Ahmed Nafees, Olayemi Awopeju, Gregory E Erhabor, Thorarinn Gislason, Tobias Welte, Amund Gulsvik, Rune Nielsen, Louisa Gnatiuc, Ali Kocabas, Guy B Marks, Talant Sooronbaev, Bertrand Hugo Mbatchou Ngahane, Cristina Barbara, A Sonia Buist The BOLD (Burden of Obstructive Lung Disease) Collaborative Research Group

doi: 10.1136/thoraxjnl-2020-216223

May 10, 2021

Chronic obstructive pulmonary disease
Bronchial gene expression signature associated with rate of subsequent FEV₁ decline in individuals with and at risk of COPD

Elizabeth J Becker, Alen Faiz, Maarten van den Berge, Wim Timens, Pieter S Hiemstra, Kristopher Clark, Gang Liu, Xiaohui Xiao, Yuriy O Alekseyev, George O'Connor, Stephen Lam, Avrum Spira, Marc E Lenburg, Katrina Steiling

doi: 10.1136/thoraxjnl-2019-214476

May 07, 2021

Paediatric lung disease
Effect of nusinersen on respiratory function in paediatric spinal muscular atrophy types 1–3

Archana Chacko, Peter D Sly, Robert S Ware, Nelufa Begum, Sean Deegan, Nicole Thomas, Leanne M Gauld

doi: 10.1136/thoraxjnl-2020-216564
Pulmonary vasculature
Loss of immune homeostasis in patients with idiopathic pulmonary arterial hypertension

Peter Heukels, Odilia B J Corneth, Denise van Uden, Jennifer A C van Hulst, Leon M van den Toorn, Annemien E van den Bosch, Marlies S Wijsenbeek, Karin A Boomars, Mirjam Kool, Rudi W Hendriks

doi: 10.1136/thoraxjnl-2020-215460
Respiratory research
Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin

Sinjini Sikdar, Annah B Wyss, Mi Kyeong Lee, Thanh T Hoang, Marie Richards, Laura E Beane Freeman, Christine Parks, Peter S Thorne, John L Hankinson, David M Umbach, Alison Motsinger-Reif, Stephanie J London

doi: 10.1136/thoraxjnl-2020-215624
Images in Thorax
The curious incident of the cast in the airway
Free

Yueqi Ge, Emily C Bartlett, Thomas Semple, Alexandra Rice, Anand Shah, Elisabetta A Renzoni

doi: 10.1136/thoraxjnl-2020-216426

April 29, 2021

Respiratory research
High-flow nasal cannula oxygen therapy for outpatients undergoing flexible bronchoscopy: a randomised controlled trial

Federico Longhini, Corrado Pelaia, Eugenio Garofalo, Andrea Bruni, Roberta Placida, Caterina Iaquinta, Eugenio Arrighi, Graziella Perri, Giada Procopio, Anna Cancelliere, Serena Rovida, Giuseppina Marrazzo, Girolamo Pelaia, Paolo Navalesi

doi: 10.1136/thoraxjnl-2021-217116
Interstitial lung disease
Nocturnal hypoxaemia in interstitial lung disease: a systematic review

Yet Hong Khor, Yvonne Ng, Duncan Sweeney, Christopher J Ryerson

doi: 10.1136/thoraxjnl-2020-216749

April 22, 2021

Interstitial lung disease
Risk of drug-induced interstitial lung disease in hospitalised patients: a nested case–control study

Taisuke Jo, Nobuaki Michihata, Hayato Yamana, Kojiro Morita, Miho Ishimaru, Yasuhiro Yamauchi, Wakae Hasegawa, Hirokazu Urushiyama, Kazuaki Uda, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Takahide Nagase

doi: 10.1136/thoraxjnl-2020-215824
Brief communication
Circulating microbial cell-free DNA is associated with inflammatory host-responses in severe pneumonia

Haopu Yang, Ghady Haidar, Nameer S Al-Yousif, Haris Zia, Daniel Kotok, Asim A Ahmed, Lily Blair, Sudeb Dalai, Sivan Bercovici, Carine Ho, Bryan J McVerry, Alison Morris, Georgios D Kitsios

doi: 10.1136/thoraxjnl-2020-216013

April 21, 2021

Paediatric lung disease
Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury

Alison W Ha, Tao Bai, David L Ebenezer, Tanvi Sethi, Tara Sudhadevi, Lizar Ace Mangio, Steven Garzon, Gloria S Pryhuber, Viswanathan Natarajan, Anantha Harijith

doi: 10.1136/thoraxjnl-2020-216469

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