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Online First

May 11, 2021

Brief communication
Chronic airflow obstruction and ambient particulate air pollution

Andre F S Amaral, Peter G J Burney, Jaymini Patel, Cosetta Minelli, Filip Mejza, David M Mannino, Terence A R Seemungal, Padukudru Anand Mahesh, Li Cher Lo, Christer Janson, Sanjay Juvekar, Meriam Denguezli, Imed Harrabi, Emiel F M Wouters, Hamid Cherkaski, Kevin Mortimer, Rain Jogi, Eric D Bateman, Elaine Fuertes, Mohammed Al Ghobain, Wan Tan, Daniel O Obaseki, Asma El Sony, Michael Studnicka, Althea Aquart-Stewart, Parvaiz Koul, Herve Lawin, Asaad Ahmed Nafees, Olayemi Awopeju, Gregory E Erhabor, Thorarinn Gislason, Tobias Welte, Amund Gulsvik, Rune Nielsen, Louisa Gnatiuc, Ali Kocabas, Guy B Marks, Talant Sooronbaev, Bertrand Hugo Mbatchou Ngahane, Cristina Barbara, A Sonia Buist The BOLD (Burden of Obstructive Lung Disease) Collaborative Research Group

doi: 10.1136/thoraxjnl-2020-216223

May 10, 2021

Chest clinic
A rare cause of an 18F-FDG positron emission tomography-positive lung lesion: look for what was lost…

Ellen Adams, Nico Mollet, Patrick Dewachter, Lynn Decoster

doi: 10.1136/thoraxjnl-2021-216919
Sleep
New forehead device in positional obstructive sleep apnoea: a randomised clinical trial

Laura Hidalgo Armas, Sandra Ingles, Rafaela Vaca, Jose Cordero-Guevara, Joaquin Duran Carro, Jorge Ullate, Ferran Barbé, Joaquin Durán-Cantolla on behalf of the Spanish Sleep Network

doi: 10.1136/thoraxjnl-2020-216167
Editorial
Further evidence that sex matters in lung development: maternal asthma and infant lung function

Lauren Deanna Benton, Wayne Morgan

doi: 10.1136/thoraxjnl-2021-217095
Chronic obstructive pulmonary disease
Bronchial gene expression signature associated with rate of subsequent FEV₁ decline in individuals with and at risk of COPD

Elizabeth J Becker, Alen Faiz, Maarten van den Berge, Wim Timens, Pieter S Hiemstra, Kristopher Clark, Gang Liu, Xiaohui Xiao, Yuriy O Alekseyev, George O'Connor, Stephen Lam, Avrum Spira, Marc E Lenburg, Katrina Steiling

doi: 10.1136/thoraxjnl-2019-214476

May 07, 2021

Asthma
The effect of diet in infancy on asthma in young adults: the Merthyr Allergy Prevention Study

Sadiyah Hand, Frank Dunstan, Ken Jones, Iolo Doull

doi: 10.1136/thoraxjnl-2020-215040
Pulmonary vasculature
Loss of immune homeostasis in patients with idiopathic pulmonary arterial hypertension

Peter Heukels, Odilia B J Corneth, Denise van Uden, Jennifer A C van Hulst, Leon M van den Toorn, Annemien E van den Bosch, Marlies S Wijsenbeek, Karin A Boomars, Mirjam Kool, Rudi W Hendriks

doi: 10.1136/thoraxjnl-2020-215460
Respiratory research
Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin

Sinjini Sikdar, Annah B Wyss, Mi Kyeong Lee, Thanh T Hoang, Marie Richards, Laura E Beane Freeman, Christine Parks, Peter S Thorne, John L Hankinson, David M Umbach, Alison Motsinger-Reif, Stephanie J London

doi: 10.1136/thoraxjnl-2020-215624
Images in Thorax
The curious incident of the cast in the airway
Free

Yueqi Ge, Emily C Bartlett, Thomas Semple, Alexandra Rice, Anand Shah, Elisabetta A Renzoni

doi: 10.1136/thoraxjnl-2020-216426
Paediatric lung disease
Effect of nusinersen on respiratory function in paediatric spinal muscular atrophy types 1–3

Archana Chacko, Peter D Sly, Robert S Ware, Nelufa Begum, Sean Deegan, Nicole Thomas, Leanne M Gauld

doi: 10.1136/thoraxjnl-2020-216564

April 29, 2021

Respiratory research
High-flow nasal cannula oxygen therapy for outpatients undergoing flexible bronchoscopy: a randomised controlled trial

Federico Longhini, Corrado Pelaia, Eugenio Garofalo, Andrea Bruni, Roberta Placida, Caterina Iaquinta, Eugenio Arrighi, Graziella Perri, Giada Procopio, Anna Cancelliere, Serena Rovida, Giuseppina Marrazzo, Girolamo Pelaia, Paolo Navalesi

doi: 10.1136/thoraxjnl-2021-217116
Respiratory infection
Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score

Juan Berenguer, Alberto M Borobia, Pablo Ryan, Jesús Rodríguez-Baño, Jose M Bellón, Inmaculada Jarrín, Jordi Carratalà, Jerónimo Pachón, Antonio J Carcas, María Yllescas, José R Arribas COVID-19@Spain and COVID@HULP Study Groups

doi: 10.1136/thoraxjnl-2020-216001
Interstitial lung disease
Nocturnal hypoxaemia in interstitial lung disease: a systematic review

Yet Hong Khor, Yvonne Ng, Duncan Sweeney, Christopher J Ryerson

doi: 10.1136/thoraxjnl-2020-216749
Editorial
Blowing hot and cold over asthma hospitalisations

Liuhua Shi

doi: 10.1136/thoraxjnl-2021-217178

April 26, 2021

Images in Thorax
A rare condition masquerading as lung cancer
Free

Eman Nasr, Sarah MacRae, Mike Dobson, David Russell, Mohamad Bittar

doi: 10.1136/thoraxjnl-2020-216689

April 22, 2021

Interstitial lung disease
Risk of drug-induced interstitial lung disease in hospitalised patients: a nested case–control study

Taisuke Jo, Nobuaki Michihata, Hayato Yamana, Kojiro Morita, Miho Ishimaru, Yasuhiro Yamauchi, Wakae Hasegawa, Hirokazu Urushiyama, Kazuaki Uda, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Takahide Nagase

doi: 10.1136/thoraxjnl-2020-215824
Critical care
Transepithelial nasal potential difference in patients with, and at risk of acute respiratory distress syndrome

Rob Mac Sweeney, Kiran Reddy, Jane C Davies, Mike Parker, Barry Kelly, J Stuart Elborn, John Conlon, Rejina M Verghis, Carolyn S Calfee, Michael A Matthay, Eric W F W Alton, Daniel F McAuley

doi: 10.1136/thoraxjnl-2020-215587
Brief communication
Circulating microbial cell-free DNA is associated with inflammatory host-responses in severe pneumonia

Haopu Yang, Ghady Haidar, Nameer S Al-Yousif, Haris Zia, Daniel Kotok, Asim A Ahmed, Lily Blair, Sudeb Dalai, Sivan Bercovici, Carine Ho, Bryan J McVerry, Alison Morris, Georgios D Kitsios

doi: 10.1136/thoraxjnl-2020-216013
Case based discussion
Acute haemoptysis, fever and abdominal pain in an adolescent from northern Australia

Daniel K Yeoh, Timothy J Ford, Joanna Chua, Miriam Bennamoun, Christopher C Blyth, Anita J Campbell, Prasanthy Hamsanathan, Ben Harkin, Jovanka King, Lisa Matthews, Charlie McLeod, Rebecca Warren, Asha C Bowen, Melanie J Thompson, André Schultz

doi: 10.1136/thoraxjnl-2020-216257

April 21, 2021

Paediatric lung disease
Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury

Alison W Ha, Tao Bai, David L Ebenezer, Tanvi Sethi, Tara Sudhadevi, Lizar Ace Mangio, Steven Garzon, Gloria S Pryhuber, Viswanathan Natarajan, Anantha Harijith

doi: 10.1136/thoraxjnl-2020-216469
Editorial
Complex interplay between greenness and air pollution in respiratory health

Elaine Fuertes, Debbie Jarvis

doi: 10.1136/thoraxjnl-2021-217272

April 16, 2021

Critical care
Attributable mortality of acute respiratory distress syndrome: a systematic review, meta-analysis and survival analysis using targeted minimum loss-based estimation

Lisa K Torres, Katherine L Hoffman, Clara Oromendia, Ivan Diaz, John S Harrington, Edward J Schenck, David R Price, Luis Gomez-Escobar, Angelica Higuera, Mayra Pinilla Vera, Rebecca M Baron, Laura E Fredenburgh, Jin-Won Huh, Augustine M K Choi, Ilias I Siempos

doi: 10.1136/thoraxjnl-2020-215950
Editorial
Can clinical benefits of modulators effectively ‘modulate’ adherence in people with CF?

Chelsea S Davis, Jonathan D Cogen

doi: 10.1136/thoraxjnl-2021-216974
Sleep
Pulse arrival time, a novel sleep cardiovascular marker: the multi-ethnic study of atherosclerosis

Younghoon Kwon, Christopher Wiles, B Eugene Parker, Brian R Clark, Min-Woong Sohn, Sara Mariani, Jin-Oh Hahn, David R Jacobs, James H Stein, Joao Lima, Vishesh Kapur, Andrew Wellman, Susan Redline, Ali Azarbarzin

doi: 10.1136/thoraxjnl-2020-216399

April 15, 2021

Critical care
Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis

Leanne M Aitken, Kalliopi Kydonaki, Bronagh Blackwood, Laurence G Trahair, Edward Purssell, Mandeep Sekhon, Timothy S Walsh

doi: 10.1136/thoraxjnl-2020-216098
Interstitial lung disease
Fibrotic extracellular matrix induces release of extracellular vesicles with pro-fibrotic miRNA from fibrocytes

Seidai Sato, Sy Giin Chong, Chandak Upagupta, Toyoshi Yanagihara, Takuya Saito, Chiko Shimbori, Pierre-Simon Bellaye, Yasuhiko Nishioka, Martin RJ Kolb

doi: 10.1136/thoraxjnl-2020-215962
Brief communication
Genetic polymorphism in ATIC is associated with effectiveness and toxicity of pemetrexed in non-small-cell lung cancer

Sabine Visser, Stijn Koolen, Nadine van Donk, Nico van Walree, Cor van der Leest, Robin Cornelissen, Ron van Schaik, Ron Mathijssen, Joachim Aerts, Bruno H Stricker

doi: 10.1136/thoraxjnl-2020-216504
Brief communication
Rectal organoid morphology analysis (ROMA) as a promising diagnostic tool in cystic fibrosis

Senne Cuyx, Anabela Santo Ramalho, Nikky Corthout, Steffen Fieuws, Eva Fürstová, Kaline Arnauts, Marc Ferrante, Catherine Verfaillie, Sebastian Munck, Mieke Boon, Marijke Proesmans, Lieven Dupont, Kris De Boeck, François Vermeulen On behalf of the Belgian Organoid Project

doi: 10.1136/thoraxjnl-2020-216368
Lung cancer
Lung cancer probability and clinical outcomes of baseline and new subsolid nodules detected on low-dose CT screening

Yeon Wook Kim, Byoung Soo Kwon, Sung Yoon Lim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Kyung Won Lee, Jae Ho Lee, Jin-Haeng Chung, Eunjeong Ji, Choon-Taek Lee

doi: 10.1136/thoraxjnl-2020-215107
Brief communication
Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

H Laura Aaltonen, Madeleine Petersson Sjögren, Jonas K F Jakobsson, Hanna Nicklasson, Sandra Diaz, Francisco Sánchez Montiel, Sophia Zackrisson, Veronica Ideböhn, Gunnar Engström, Jakob Löndahl, Per Wollmer

doi: 10.1136/thoraxjnl-2020-214523
Non-invasive ventilation
Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis

Marius Lebret, Antoine Léotard, Jean Louis Pépin, Wolfram Windisch, Emelie Ekkernkamp, Mercedes Pallero, M-Ángeles Sánchez-Quiroga, Nicholas Hart, Julia L Kelly, Maxime Patout, Georg Chistian Funk, Marieke L Duiverman, Juan F Masa, Anita Simonds, Patrick Brian Murphy, Peter J Wijkstra, Michael Dreher, Jan Storre, Charles Khouri, Jean-Christian Borel

doi: 10.1136/thoraxjnl-2020-215613
Brief communication
Inhaled nitric oxide improves the hepatopulmonary syndrome: a physiologic analysis

Samir Gupta, Rosalind Tang, Abdul Al-Hesayen

doi: 10.1136/thoraxjnl-2020-216128

April 09, 2021

Editorial
Improved asthma control during the COVID-19 pandemic: are there lessons to be learnt?
Free

Imogen P Skene, Paul E Pfeffer

doi: 10.1136/thoraxjnl-2021-216930

April 07, 2021

Chronic obstructive pulmonary disease
Small airway determinants of airflow limitation in chronic obstructive pulmonary disease

Vasiliy V Polosukhin, Sergey S Gutor, Rui-Hong Du, Bradley W Richmond, Pierre P Massion, Pingsheng Wu, Justin M Cates, Kim L Sandler, Stephen I Rennard, Timothy S Blackwell

doi: 10.1136/thoraxjnl-2020-216037

March 30, 2021

Respiratory epidemiology
Epidemiology and prognostic factors of pleural empyema

Antonio Bobbio, Samir Bouam, Jerome Frenkiel, Kevin Zarca, Ludovic Fournel, Emelyne Canny, Philippe Icard, Raphaël Porcher, Marco Alifano

doi: 10.1136/thoraxjnl-2020-215267

March 29, 2021

Brief communication
Decrease in hospital admissions for respiratory diseases during the COVID-19 pandemic: a nationwide claims study
Free

Kyungmin Huh, Young-Eun Kim, Wonjun Ji, Dong Wook Kim, Eun-Joo Lee, Jong-Hun Kim, Ji-Man Kang, Jaehun Jung

doi: 10.1136/thoraxjnl-2020-216526
Asthma
Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data

Syed A Shah, Jennifer K Quint, Bright I Nwaru, Aziz Sheikh

doi: 10.1136/thoraxjnl-2020-216512
Asthma
Impact of COVID-19 lockdown on emergency asthma admissions and deaths: national interrupted time series analyses for Scotland and Wales
Free

Gwyneth A Davies, Mohammad A Alsallakh, Shanya Sivakumaran, Eleftheria Vasileiou, Ronan A Lyons, Chris Robertson, Aziz Sheikh EAVE II Collaborators

doi: 10.1136/thoraxjnl-2020-216380

March 25, 2021

Cystic fibrosis
Longitudinal effects of ivacaftor and medicine possession ratio in people with the Gly551Asp mutation: a 5-year study

Ruth Marian Mitchell, Andrew M Jones, Katie Stocking, Philip Foden, Peter J Barry

doi: 10.1136/thoraxjnl-2020-215556
Critical care
Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Free

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud, Claire Grange, Hervé Lobbes, Steeve Provencher, Jean-Christophe Lega

doi: 10.1136/thoraxjnl-2020-215383
Brief communication
Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study

Andrew J Swift, Frederick Wilson, Marcella Cogliano, Lindsay Kendall, Faisal Alandejani, Samer Alabed, Paul Hughes, Yousef Shahin, Laura Saunders, Charlotte Oram, David Capener, Alex Rothman, Pankaj Garg, Christopher Johns, Matthew Austin, Alistair Macdonald, Jo Pickworth, Peter Hickey, Robin Condliffe, Anthony Cahn, Allan Lawrie, Jim M Wild, David G Kiely

doi: 10.1136/thoraxjnl-2020-216078

March 23, 2021

Asthma
Temperature variability and asthma hospitalisation in Brazil, 2000–2015: a nationwide case-crossover study

Yao Wu, Rongbin Xu, Bo Wen, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo H Saldiva, Shanshan Li, Yuming Guo

doi: 10.1136/thoraxjnl-2020-216549
Brief communication
Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study

Belén Pérez-Mies, María Gómez-Rojo, Irene Carretero-Barrio, Tommaso Bardi, Amparo Benito, Mónica García-Cosío, Álvaro Caballero, Raul de Pablo, Juan Carlos Galán, David Pestaña, Jose Palacios

doi: 10.1136/thoraxjnl-2020-216714
Pulmonary vasculature
Non-invasive early exclusion of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: the InShape II study

Gudula J A M Boon, Yvonne M Ende-Verhaar, Roisin Bavalia, Lahassan H El Bouazzaoui, Marion Delcroix, Olga Dzikowska-Diduch, Menno V Huisman, Katarzyna Kurnicka, Albert T A Mairuhu, Saskia Middeldorp, Piotr Pruszczyk, Dieuwertje Ruigrok, Peter Verhamme, Hubert W Vliegen, Anton Vonk Noordegraaf, Joris W J Vriend, Frederikus A Klok InShape II study group

doi: 10.1136/thoraxjnl-2020-216324

March 15, 2021

Respiratory infection
Empiric antibiotics for community-acquired pneumonia in adult patients: a systematic review and a network meta-analysis

Lara Montes-Andujar, Elena Tinoco, Orville Baez-Pravia, Carlos Martin-Saborido, Pablo Blanco-Schweizer, Carmen Segura, Estefania Prol Silva, Vivivan Reyes, Ana Rodriguez Cobo, Carmen Zurdo, Verónica Angel, Olga Varona, José Valero, Rafael Suarez del Villar, Guillermo Ortiz, Julio Villanueva, Justo Menéndez, Jesús Blanco, Antoni Torres, Pablo A Cardinal-Fernández

doi: 10.1136/thoraxjnl-2019-214054

March 12, 2021

State of the art review
Role of extracellular vesicles in chronic lung disease

Anne Trappe, Seamas C Donnelly, Paul McNally, Judith A Coppinger

doi: 10.1136/thoraxjnl-2020-216370

March 10, 2021

State of the art review
Use of preclinical models for malignant pleural mesothelioma

Marie Shamseddin, Joanna Obacz, Mathew J Garnett, Robert Campbell Rintoul, Hayley Elizabeth Francies, Stefan John Marciniak

doi: 10.1136/thoraxjnl-2020-216602

February 25, 2021

Brief communication
Bronchiectasis severity correlates with outcome in patients with primary antibody deficiency

Jimstan Periselneris, Silke Schelenz, Michael Loebinger, Patricia Macedo, Zoe Adhya, Darius Armstrong-James, W Peter Kelleher

doi: 10.1136/thoraxjnl-2020-215585
Environmental exposure
Greenness may improve lung health in low–moderate but not high air pollution areas: Seven Northeastern Cities’ study

Yang Zhou, Dinh S Bui, Jennifer L Perret, Adrian J Lowe, Caroline J Lodge, Iana Markevych, Joachim Heinrich, Michael S Bloom, Luke D Knibbs, Bin Jalaludin, Bo-Yi Yang, Hong-Yao Yu, Xiao-Wen Zeng, Yunjiang Yu, Shyamali C Dharmage, Guang-Hui Dong

doi: 10.1136/thoraxjnl-2020-214767
Paediatric lung disease
Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts

Patricia de Gouveia Belinelo, Adam M Collison, Vanessa E Murphy, Paul D Robinson, Kathryn Jesson, Kate Hardaker, Ediane de Queiroz Andrade, Christopher Oldmeadow, Gabriela Martins Costa Gomes, Peter D Sly, Jakob Usemann, Rhea Appenzeller, Olga Gorlanova, Oliver Fuchs, Philipp Latzin, Peter G Gibson, Urs Frey, Joerg Mattes

doi: 10.1136/thoraxjnl-2020-215526

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