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Online First

August 10, 2022

Respiratory research
Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis

Yue Su, Johnatas Dutra Silva, Declan Doherty, David A Simpson, Daniel J Weiss, Sara Rolandsson-Enes, Daniel F McAuley, Cecilia M O'Kane, Derek P Brazil, Anna D Krasnodembskaya

doi: 10.1136/thoraxjnl-2021-218194

August 05, 2022

Interstitial lung disease
MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study

John S Kim, Ani W Manichaikul, Eric A Hoffman, Pallavi Balte, Michaela R Anderson, Elana J Bernstein, Purnema Madahar, Elizabeth C Oelsner, Steven M Kawut, Artur Wysoczanski, Andrew F Laine, Ayodeji Adegunsoye, Jennie Z Ma, Margaret A Taub, Rasika A Mathias, Stephen S Rich, Jerome I Rotter, Imre Noth, Christine Kim Garcia, R Graham Barr, Anna J Podolanczuk

doi: 10.1136/thorax-2021-218139

July 30, 2022

Asthma
Preterm or early term birth and long-term risk of asthma into midadulthood: a national cohort and cosibling study

Casey Crump, Jan Sundquist, Kristina Sundquist

doi: 10.1136/thorax-2022-218931

July 27, 2022

Respiratory epidemiology
Patient outcomes following emergency admission to hospital for COVID-19 compared with influenza: retrospective cohort study

Thomas Woodcock, Geva Greenfield, Ajit Lalvani, Azeem Majeed, Paul Aylin

doi: 10.1136/thoraxjnl-2021-217858

July 20, 2022

Smoking
Assessment of formal tobacco treatment and smoking cessation in dual users of cigarettes and e-cigarettes

Brendan T Heiden, Timothy B Baker, Nina Smock, Giang Pham, Jingling Chen, Laura J Bierut, Li-Shiun Chen

doi: 10.1136/thorax-2022-218680

July 18, 2022

Asthma
Single dose of budesonide/formoterol turbuhaler compared to salbutamol pMDI for speed of bronchodilator onset in asthma: a randomised cross-over trial

Nethmi Kearns, Mathew Williams, Pepa Bruce, Melissa Black, Ciléin Kearns, Jenny Sparks, Irene Braithwaite, Mark Weatherall, Richard Beasley

doi: 10.1136/thorax-2022-219052

July 16, 2022

Interstitial lung disease
The relationship between interstitial lung abnormalities, mortality, and multimorbidity: a cohort study

Jason Leigh Sanders, Gisli Axelsson, Rachel Putman, Aravind Menon, Josée Dupuis, Hanfei Xu, Shuai Wang, Joanne Murabito, Ramachandran Vasan, Tetsuro Araki, Mizuki Nishino, George R Washko, Hiroto Hatabu, George O'Connor, Gunnar Gudmundsson, Vilmundur Gudnason, Gary M Hunninghake

doi: 10.1136/thoraxjnl-2021-218315

July 14, 2022

Lung cancer
Effects of enhanced recovery after surgery plus pulmonary rehabilitation on complications after video-assisted lung cancer surgery: a multicentre randomised controlled trial

Yu Zheng, Mao Mao, Fang Li, Lu Wang, Xintong Zhang, Xiu Zhang, Haiming Wang, Huiqing Zhou, Meifang Ji, Yulong Wang, Liang Liu, Quan Zhu, Jan D Reinhardt, Xiao Lu

doi: 10.1136/thoraxjnl-2021-218183

July 06, 2022

Respiratory infection
C reactive protein utilisation, a biomarker for early COVID-19 treatment, improves lenzilumab efficacy: results from the randomised phase 3 ‘LIVE-AIR’ trial

Zelalem Temesgen, Colleen F Kelley, Frank Cerasoli, Adrian Kilcoyne, Dale Chappell, Cameron Durrant, Omar Ahmed, Gabrielle Chappell, Victoria Catterson, Christopher Polk, Andrew Badley, Vincent C Marconi LIVE-AIR Study Group

doi: 10.1136/thoraxjnl-2022-218744

June 29, 2022

Chronic obstructive pulmonary disease
Subtyping emphysematous COPD by respiratory volume change distributions on CT

Hiroshi Shima, Naoya Tanabe, Akira Oguma, Kaoruko Shimizu, Shizuo Kaji, Kunihiko Terada, Tsuyoshi Oguma, Takeshi Kubo, Masaru Suzuki, Hironi Makita, Atsuyasu Sato, Masaharu Nishimura, Susumu Sato, Satoshi Konno, Toyohiro Hirai

doi: 10.1136/thoraxjnl-2021-218288

June 16, 2022

Asthma
Environmental risks and sphingolipid signatures in adult asthma and its phenotypic clusters: a multicentre study

Chao-Chien Wu, Chin-Chou Wang, Wen-Yu Chung, Chau-Chyun Sheu, Yi-Hsin Yang, Ming-Yen Cheng, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin, Yu-Feng Wei, Ching-Hsiung Lin, Sheng-Hao Lin, Jeng-Yuan Hsu, Wei-Chang Huang, Chia-Cheng Tseng, Yung-Fa Lai, Meng-Hsuan Cheng, Huang-Chi Chen, Chih-Jen Yang, Shih-Chang Hsu, Chian-Heng Su, Chien-Jen Wang, Huei-Ju Liu, Hua-Ling Chen, Yuan-Ting Hsu, Chih-Hsing Hung, Chon-Lin Lee, Ming-Shyan Huang, Shau-Ku Huang

doi: 10.1136/thoraxjnl-2021-218396

June 10, 2022

Respiratory infection
Ultra-low-dose CT versus chest X-ray for patients suspected of pulmonary disease at the emergency department: a multicentre randomised clinical trial

Inge A H van den Berk, Maadrika M N P Kanglie, Tjitske S R van Engelen, Josje Altenburg, Jouke T Annema, Ludo F M Beenen, Bart Boerrigter, Marije K Bomers, Paul Bresser, Elvin Eryigit, Maarten Groenink, Suzanne M R Hochheimer, Frits Holleman, Jos A J Kooter, Ramon B van Loon, Mitran Keijzers, Ivo van der Lee, Paul Luijendijk, Lilian J Meijboom, Saskia Middeldorp, Laura J Schijf, Robin Soetekouw, Ralf W Sprengers, Alexander D Montauban van Swijndregt, Wouter de Monyé, Milan L Ridderikhof, Michiel M Winter, Shandra Bipat, Marcel G W Dijkgraaf, Patrick M M Bossuyt, Jan M Prins, Jaap Stoker on behalf of the OPTIMACT study group

doi: 10.1136/thoraxjnl-2021-218337

May 29, 2022

Interstitial lung disease
Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

Luke M Kraven, Adam R Taylor, Philip L Molyneaux, Toby M Maher, John E McDonough, Marco Mura, Ivana V Yang, David A Schwartz, Yong Huang, Imre Noth, Shwu Fan Ma, Astrid J Yeo, William A Fahy, R Gisli Jenkins, Louise V Wain

doi: 10.1136/thoraxjnl-2021-218563

May 17, 2022

Critical care
High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial
Free

Claudia Crimi, Alberto Noto, Fabiana Madotto, Mariachiara Ippolito, Santi Nolasco, Raffaele Campisi, Stefano De Vuono, Giuseppe Fiorentino, Ioannis Pantazopoulos, Athanasios Chalkias, Alessandro Libra, Alessio Mattei, Raffaele Scala, Enrico M Clini, Begum Ergan, Manel Lujan, Joao Carlos Winck, Antonino Giarratano, Annalisa Carlucci, Cesare Gregoretti, Paolo Groff, Andrea Cortegiani on behalf of the COVID-HIGH Investigators

doi: 10.1136/thoraxjnl-2022-218806

May 10, 2022

Respiratory epidemiology
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease

Anna Guyatt, Catherine John, Alexander T Williams, Nick Shrine, Nicola F Reeve, SpiroMeta consortium, Ian Sayers, Ian Hall, Louise V Wain, Nuala Sheehan, Frank Dudbridge, Martin D Tobin

doi: 10.1136/thoraxjnl-2021-217993

May 02, 2022

Asthma
Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma

Alberta L Wang, Lies Lahousse, Amber Dahlin, Ahmed Edris, Michael McGeachie, Sharon M Lutz, Joanne E Sordillo, Guy Brusselle, Jessica Lasky-Su, Scott T Weiss, Carlos Iribarren, Meng X Lu, Kelan G Tantisira, Ann C Wu

doi: 10.1136/thoraxjnl-2021-217674

April 22, 2022

Paediatric lung disease
Bronchopulmonary dysplasia and expiratory airflow at 8 years in children born extremely preterm in the post-surfactant era

Lex William Doyle, Sarath Ranganathan, Jeanie Cheong The Victorian Infant Collaborative Study Group

doi: 10.1136/thoraxjnl-2022-218792

April 21, 2022

Lung cancer
Impact of time-to-treatment on survival for advanced non-small cell lung cancer patients in the Netherlands: a nationwide observational cohort study

Sosse E Klarenbeek, Mieke J Aarts, Michel M van den Heuvel, Mathias Prokop, Marcia Tummers, Olga C J Schuurbiers

doi: 10.1136/thoraxjnl-2021-218059
Respiratory infection
Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1β in Klebsiella-mediated acute respiratory distress syndrome

Li-Tzu Wang, B Linju Yen, Hsiu-Huan Wang, Ying-Yin Chao, Wei Lee, Li-Yueh Huang, Sheng-Kang Chiu, L. Kristopher Siu, Ko-Jiunn Liu, Huey-Kang Sytwu, Men-Luh Yen

doi: 10.1136/thoraxjnl-2021-217928
Chronic obstructive pulmonary disease
Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD: a randomised controlled trial

Marc Spielmanns, Rainer Gloeckl, Inga Jarosch, Daniela Leitl, Tessa Schneeberger, Tobias Boeselt, Stephan Huber, Pawandeep Kaur-Bollinger, Bernhard Ulm, Claudia Mueller, Jonas Bjoerklund, Sabine Spielmanns, Wolfram Windisch, Anna-Maria Pekacka-Egli, Andreas Rembert Koczulla

doi: 10.1136/thoraxjnl-2021-218338
Lung transplantation
Altered purine metabolism at reperfusion affects clinical outcome in lung transplantation

Cristina Baciu, Jason Shin, Michael Hsin, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu

doi: 10.1136/thoraxjnl-2021-217498

April 15, 2022

Cystic fibrosis
Evaluation of clinically relevant changes in the lung clearance index in children with cystic fibrosis and healthy controls

Lucy Perrem, Sanja Stanojevic, Melinda Solomon, Hartmut Grasemann, Neil Sweezey, Valerie Waters, Don B Sanders, Stephanie D Davis, Felix Ratjen

doi: 10.1136/thoraxjnl-2021-218347

April 11, 2022

Thoracic surgery
Cytoreductive surgery with hyperthermic intrathoracic chemotherapy for malignant pleural mesothelioma: a systematic review

Alan G. Dawson, Kudzayi Kutywayo, Seid B. Mohammed, Dean A. Fennell, Apostolos Nakas

doi: 10.1136/thoraxjnl-2021-218214

March 31, 2022

Environmental exposure
Short-term exposure to ambient air pollution and individual emergency department visits for COVID-19: a case-crossover study in Canada

Eric Lavigne, Niilo Ryti, Antonio Gasparrini, Francesco Sera, Scott Weichenthal, Hong Chen, Teresa To, Greg J Evans, Liu Sun, Aman Dheri, Lionnel Lemogo, Serge Olivier Kotchi, Dave Stieb

doi: 10.1136/thoraxjnl-2021-217602
Tuberculosis
Airflow obstruction and small airway dysfunction following pulmonary tuberculosis: a cross-sectional survey

Zhenzhen Xing, Tieying Sun, Jean-Paul Janssens, Di Chai, Weiming Liu, Yaqi Tong, Yuxia Wang, Yali Ma, Mingming Pan, Jia Cui, Chen Wang, YanFei Guo

doi: 10.1136/thoraxjnl-2021-218345

March 30, 2022

Smoking
Cigarette smoking is a secondary cause of folliculin loss

Xiuying Li, Yandong Lai, Zachary Lane, Hilary Strollo, Kazuya Tanimura, John C Sembrat, Chunbin Zou, Michael M Myerburg, Mauricio Rojas, Steven Shapiro, Yu Jiang, Toru Nyunoya

doi: 10.1136/thoraxjnl-2021-217197
Respiratory infection
Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis

Yandong Lai, Xiuying Li, Tiao Li, Xiaoyun Li, Toru Nyunoya, Kong Chen, Georgios Kitsios, Mehdi Nouraie, Yingze Zhang, Bryan J McVerry, Janet S Lee, Rama K Mallmapalli, Chunbin Zou

doi: 10.1136/thoraxjnl-2021-217526

March 24, 2022

Interstitial lung disease
Derivation and validation of a simple multidimensional index incorporating exercise capacity parameters for survival prediction in idiopathic pulmonary fibrosis

Abhimanyu Chandel, Jean Pastre, Solène Valery, Christopher S King, Steven D Nathan

doi: 10.1136/thoraxjnl-2021-218440

December 01, 2021

Skeletal muscle
CT pectoralis muscle area is associated with DXA lean mass and correlates with emphysema progression in a tobacco-exposed cohort

Michael Emmet O'Brien, Richard H Zou, Nathan Hyre, Joseph K Leader, Carl R Fuhrman, Frank C Sciurba, Mehdi Nouraie, Jessica Bon

doi: 10.1136/thoraxjnl-2021-217710

October 16, 2021

Chronic obstructive pulmonary disease
Automatic oxygen titration versus constant oxygen flow rates during walking in COPD: a randomised controlled, double-blind, crossover trial

Tessa Schneeberger, Inga Jarosch, Daniela Leitl, Rainer Gloeckl, Wolfgang Hitzl, Clancy John Dennis, Tatjana Geyer, Carl-Peter Criée, Andreas Rembert Koczulla, Klaus Kenn

doi: 10.1136/thoraxjnl-2020-216509

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