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Online First

November 04, 2021

Respiratory infection
Aerosol emission from the respiratory tract: an analysis of aerosol generation from oxygen delivery systems

Fergus W Hamilton, Florence K A Gregson, David T Arnold, Sadiyah Sheikh, Kirsty Ward, Jules Brown, Ed Moran, Carrie White, Anna J Morley, AERATOR Group, Bryan R Bzdek, Jonathan P Reid, Nicholas A Maskell, James William Dodd

doi: 10.1136/thoraxjnl-2021-217577

November 02, 2021

Brief communication
Are aerosols generated during lung function testing in patients and healthy volunteers? Results from the AERATOR study

Sadiyah Sheikh, Fergus W Hamilton, George W Nava, Florence K A Gregson, David T Arnold, Colleen Riley, Jules Brown, AERATOR Group, Jonathan P Reid, Bryan R Bzdek, Nicholas A Maskell, James William Dodd

doi: 10.1136/thoraxjnl-2021-217671

October 29, 2021

Lung cancer
Selection of eligible participants for screening for lung cancer using primary care data

Emma L O'Dowd, Kevin ten Haaf, Jaspreet Kaur, Stephen W Duffy, William Hamilton, Richard B Hubbard, John K Field, Matthew EJ Callister, Sam M Janes, Harry J de Koning, Janette Rawlinson, David R Baldwin

doi: 10.1136/thoraxjnl-2021-217142
Images in Thorax
Transposition of the great indwelling pleural catheter
Free

Eihab O Bedawi, Radhika Banka, Fergus V Gleeson, Najib M Rahman, John M Wrightson

doi: 10.1136/thoraxjnl-2021-217956
Critical care
Non-invasive ventilation versus invasive weaning in critically ill adults: a systematic review and meta-analysis

Karen E A Burns, James Stevenson, Matthew Laird, Neill K J Adhikari, Yuchong Li, Cong Lu, Xiaolin He, Wentao Wang, Zhenting Liang, Lu Chen, Haibo Zhang, Jan O Friedrich

doi: 10.1136/thoraxjnl-2021-216993

October 27, 2021

Cystic fibrosis
Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trial

David P Nichols, Pradeep K Singh, Arthur Baines, Lindsay J Caverly, James F Chmiel, Ronald L GIbson, Jorge Lascano, Sarah J Morgan, George Retsch-Bogart, Lisa Saiman, Hossein Sadeghi, Joanne L Billings, Sonya L Heltshe, Shannon Kirby, Ada Kong, Jerry A Nick, Nicole Mayer-Hamblett TEACH Study Group

doi: 10.1136/thoraxjnl-2021-217782
Rehabilitation
Randomised controlled trial to investigate the use of high-frequency airway oscillations as training to improve dyspnoea (TIDe) in COPD

Enya Daynes, Neil Greening, Sally J Singh

doi: 10.1136/thoraxjnl-2021-217072
Cystic fibrosis
Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis

Alex R Horsley, John Belcher, Katie Bayfield, Brooke Bianco, Steve Cunningham, Catherine Fullwood, Andrew Jones, Anna Shawcross, Jaclyn A Smith, Anirban Maitra, Francis J Gilchrist

doi: 10.1136/thoraxjnl-2021-216928

October 25, 2021

Respiratory research
Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrier

Namho Kim, Gijung Kwak, Jason Rodriguez, Alessandra Livraghi-Butrico, Xinyuan Zuo, Valentina Simon, Eric Han, Siddharth Kaup Shenoy, Nikhil Pandey, Marina Mazur, Susan E Birket, Anthony Kim, Steven M Rowe, Richard Boucher, Justin Hanes, Jung Soo Suk

doi: 10.1136/thoraxjnl-2020-215185

October 22, 2021

Editorial
Adherence to CF treatment can be improved with the right approach!

André Schultz

doi: 10.1136/thoraxjnl-2021-218134

October 21, 2021

Brief communication
Acceptability of hygiene, face covering and social distancing interventions to prevent exacerbations in people living with airways diseases

John R Hurst, Andrew Cumella, Camila Nagoda Niklewicz, Keir E J Philip, Victoria Singh, Nicholas S Hopkinson

doi: 10.1136/thoraxjnl-2021-217981
Brief communication
Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study

Nadia Nathan, Marie-Emeline Montagne, Odile Macchi, Paul-André Rosental, Simon Chauveau, Florence Jeny, Lucile Sesé, Rola Abou Taam, Manon Brocvielle, Jacques Brouard, Mickaël Catinon, Catherine Chapelon-Abric, Fleur Cohen-Aubart, Christophe Delacourt, Céline Delestrain, Antoine Deschildre, Antoine Dossier, Ralph Epaud, Julien Haroche, Véronique Houdouin, Dominique Israel-Biet, Karine Juvin, Sylvain Le Jeune, Francois Lionnet, Ulrich Meinzer, Marie Mittaine, Hilario Nunes, Sarah Mattioni, Jean-Marc Naccache, Marie-Hélène Odièvre, Michel Vincent, Annick Clement, Dominique Valeyre, Catherine Cavalin for the French Sarcoidosis Group and the Silicosis Research Group

doi: 10.1136/thoraxjnl-2021-217870

October 16, 2021

Chronic obstructive pulmonary disease
Automatic oxygen titration versus constant oxygen flow rates during walking in COPD: a randomised controlled, double-blind, crossover trial

Tessa Schneeberger, Inga Jarosch, Daniela Leitl, Rainer Gloeckl, Wolfgang Hitzl, Clancy John Dennis, Tatjana Geyer, Carl-Peter Criée, Andreas Rembert Koczulla, Klaus Kenn

doi: 10.1136/thoraxjnl-2020-216509

October 14, 2021

Respiratory research
Metabolomic differences in lung function metrics: evidence from two cohorts

Rachel S. Kelly, Isobel D. Stewart, Haley Bayne, Priyadarshini Kachroo, Avron Spiro III, Pantel Vokonas, David Sparrow, Scott T. Weiss, Hanna M. Knihtilä, Augusto A. Litonjua, Nicholas J. Wareham, Claudia Langenberg, Jessica A. Lasky-Su

doi: 10.1136/thoraxjnl-2020-216639

October 06, 2021

Asthma
Blood eosinophil cationic protein and eosinophil-derived neurotoxin are associated with different asthma expression and evolution in adults

Vanessa Granger, Farid Zerimech, Jinan Arab, Valerie Siroux, Patricia de Nadai, Anne Tsicopoulos, Régis Matran, Zeina Akiki, Rachel Nadif

doi: 10.1136/thoraxjnl-2021-217343

October 04, 2021

State of the art review
Infections due to dysregulated immunity: an emerging complication of cancer immunotherapy

Tommaso Morelli, Kohei Fujita, Gil Redelman-Sidi, Paul T Elkington

doi: 10.1136/thoraxjnl-2021-217260
Brief communication
Acute and sustained increase in endothelial biomarkers in COVID-19
Free

Raúl Méndez, Paula González-Jiménez, Ana Latorre, Mónica Piqueras, Leyre Bouzas, Katheryn Yépez, Ana Ferrando, Enrique Zaldívar-Olmeda, Antonio Moscardó, Ricardo Alonso, Soledad Reyes, Rosario Menéndez

doi: 10.1136/thoraxjnl-2020-216797

September 30, 2021

Asthma
Epinephrine (adrenaline) compared to selective beta-2-agonist in adults or children with acute asthma: a systematic review and meta-analysis

Christina Baggott, Jo Katherine Hardy, Jenny Sparks, Doñah Sabbagh, Richard Beasley, Mark Weatherall, James Fingleton

doi: 10.1136/thoraxjnl-2021-217124
Interstitial lung disease
Impact of smoking on the development of idiopathic pulmonary fibrosis: results from a nationwide population-based cohort study

Won Bae, Chang-Hoon Lee, Jinwoo Lee, Young Whan Kim, Kyungdo Han, Sun Mi Choi

doi: 10.1136/thoraxjnl-2020-215386

September 29, 2021

Brief communication
Physical, cognitive and mental health outcomes in 1-year survivors of COVID-19-associated ARDS
Free

Nicola Latronico, Elena Peli, Stefano Calza, Federica Rodella, Maria Paola Novelli, Andrea Cella, John Marshall, Dale M Needham, Frank Antony Rasulo, Simone Piva LOTO Investigators

doi: 10.1136/thoraxjnl-2021-218064
Cough
Risk and impact of chronic cough in obese individuals from the general population

Eskild Morten Landt, Yunus Çolak, Børge G Nordestgaard, Peter Lange, Morten Dahl

doi: 10.1136/thoraxjnl-2020-216351
Occupational lung disease
Risk of asbestosis, mesothelioma, other lung disease or death among motor vehicle mechanics: a 45-year Danish cohort study

Reimar Wernich Thomsen, Anders Hammerich Riis, Esben Meulengracht Flachs, David H Garabrant, Jens Peter Ellekilde Bonde, Henrik Toft Sørensen

doi: 10.1136/thoraxjnl-2020-215041

September 27, 2021

Asthma
Lung function, airway and peripheral basophils and eosinophils are associated with molecular pharmacogenomic endotypes of steroid response in severe asthma

Alvin T Kho, Michael J McGeachie, Jiang Li, Robert P Chase, Sami S Amr, Annette T Hastie, Gregory A Hawkins, Xingnan Li, Geoffrey L Chupp, Deborah A Meyers, Eugene R Bleecker, Scott T Weiss, Kelan G Tantisira

doi: 10.1136/thoraxjnl-2020-215523

September 23, 2021

Cystic fibrosis
Projecting the impact of triple CFTR modulator therapy on intravenous antibiotic requirements in cystic fibrosis using patient registry data combined with treatment effects from randomised trials

Ruth H Keogh, Rebecca Cosgriff, Eleni-Rosalina Andrinopoulou, Keith G Brownlee, Siobhán B Carr, Karla Diaz-Ordaz, Emily Granger, Nicholas P Jewell, Alex Lewin, Clemence Leyrat, Daniela K Schlüter, Maarten van Smeden, Rhonda D Szczesniak, Gary J Connett

doi: 10.1136/thoraxjnl-2020-216265
Editorial
Inhaled corticosteroids in COPD: risk and benefits

Christer Janson

doi: 10.1136/thoraxjnl-2021-217930
Cystic fibrosis
Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial

Martin J Wildman, Alicia O’Cathain, Chin Maguire, Madelynne A Arden, Marlene Hutchings, Judy Bradley, Stephen J Walters, Pauline Whelan, John Ainsworth, Iain Buchan, Laura Mandefield, Laura Sutton, Paul Tappenden, Rachel A Elliott, Zhe Hui Hoo, Sarah J Drabble, Daniel Beever CFHealthHub Study Team

doi: 10.1136/thoraxjnl-2021-217594
Brief communication
Exploring the challenges of accessing medication for patients with cystic fibrosis

Sophie Herbert, Nicola Jane Rowbotham, Sherie Smith, Patrick Wilson, Zoe C Elliott, Paul A Leighton, Alistair Duff, Alan Robert Smyth

doi: 10.1136/thoraxjnl-2021-217140
Interstitial lung disease
Global and regional burden of interstitial lung disease and pulmonary sarcoidosis from 1990 to 2019: results from the Global Burden of Disease study 2019

Xiaoqian Ma, Lili Zhu, Jonathan S Kurche, Huijuan Xiao, Huaping Dai, Chen Wang

doi: 10.1136/thoraxjnl-2020-216732

September 11, 2021

Brief communication
Gender-based differences in community-wide screening for pulmonary tuberculosis in Karachi, Pakistan: an observational study of 311 732 individuals undergoing screening

Shifa Salman Habib, Syed Mohammad Asad Zaidi, Wafa Zehra Jamal, Kiran Sohail Azeemi, Salman Khan, Saira Khowaja, Abdul Khalique Domki, Aamir Khan, Faiz Ahmad Khan

doi: 10.1136/thoraxjnl-2020-216409
Asthma
Endoplasmic reticulum-unfolded protein response signalling is altered in severe eosinophilic and neutrophilic asthma

Prabuddha S Pathinayake, David W Waters, Kristy S Nichol, Alexandra C Brown, Andrew T Reid, Alan Chen-Yu Hsu, Jay C Horvat, Lisa G Wood, Katherine J Baines, Jodie L Simpson, Peter G Gibson, Philip M Hansbro, Peter A B Wark

doi: 10.1136/thoraxjnl-2020-215979

September 08, 2021

Brief communication
Airway inflammation in severe asthmatics with acid gastro-oesophageal reflux

Nicole Tanner, Sejal Saglani, Albert M Li, Andrew Bush, Louise Fleming

doi: 10.1136/thoraxjnl-2020-216304
Pulmonary vasculature
Diagnostic accuracy of focused deep venous, lung, cardiac and multiorgan ultrasound in suspected pulmonary embolism: a systematic review and meta-analysis

Casper Falster, Niels Jacobsen, Karen Ehlers Coman, Mikkel Højlund, Thomas Agerbo Gaist, Stefan Posth, Jacob Eifer Møller, Mikkel Brabrand, Christian B Laursen

doi: 10.1136/thoraxjnl-2021-216838

September 05, 2021

Editorial
Call for emergency action to limit global temperature increases, restore biodiversity and protect health

Lukoye Atwoli, Abdullah H Baqui, Thomas Benfield, Raffaella Bosurgi, Fiona Godlee, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Carlos Augusto Monteiro, Ian Norman, Kirsten Patrick, Nigel Praities, Marcel GM Olde Rikkert, Eric J Rubin, Peush Sahni, Richard Smith, Nicholas J Talley, Sue Turale, Damián Vázquez

doi: 10.1136/thoraxjnl-2021-218113

August 30, 2021

Interstitial lung disease
Survival after inpatient or outpatient pulmonary rehabilitation in patients with fibrotic interstitial lung disease: a multicentre retrospective cohort study

Sabina Anna Guler, Seo Am Hur, Michael K Stickland, Patrick Brun, Luc Bovet, Anne E Holland, Janet Bondarenko, Nathan Hambly, Joshua Wald, Nima Makhdami, Michael Kreuter, Rainer Gloeckl, Inga Jarosch, Benjamin Tan, Kerri A Johannson, S Ainslie McBride, Kaissa De Boer, Jacqueline S Sandoz, Kelly Sun, Deborah Assayag, Surya P Bhatt, Julie Morisset, Vincent Ferraro, Chris Garvey, Pat G Camp, Christopher J Ryerson

doi: 10.1136/thoraxjnl-2021-217361

August 26, 2021

Chronic obstructive pulmonary disease
Use of inhaled corticosteroids and risk of acquiring Pseudomonas aeruginosa in patients with chronic obstructive pulmonary disease

Josefin Eklöf, Truls Sylvan Ingebrigtsen, Rikke Sørensen, Mohamad Isam Saeed, Imane Achir Alispahic, Pradeesh Sivapalan, Jonas Bredtoft Boel, Jette Bangsborg, Christian Ostergaard, Ram Benny Dessau, Ulrich Stab Jensen, Ejvind Frausing Hansen, Therese Sophie Lapperre, Howraman Meteran, Torgny Wilcke, Niels Seersholm, Jens-Ulrik Stæhr Jensen

doi: 10.1136/thoraxjnl-2021-217160

August 24, 2021

Editorial
Placental dysfunction and impaired fetal growth: a relationship with bronchopulmonary dysplasia and pulmonary hypertension

Karen Young, Ilene Sosenko, Nelson Claure

doi: 10.1136/thoraxjnl-2021-217476
Rehabilitation
Effects of exercise training in people with non-small cell lung cancer before lung resection: a systematic review and meta-analysis

Francis-Edouard Gravier, Pauline Smondack, Guillaume Prieur, Clement Medrinal, Yann Combret, Jean-François Muir, Jean-Marc Baste, Antoine Cuvelier, Fairuz Boujibar, Tristan Bonnevie

doi: 10.1136/thoraxjnl-2021-217242
Editorial
Establishing the exposure–outcome relation between airborne particulate matter and children’s health

Renyi Zhang, Natalie M Johnson, Yixin Li

doi: 10.1136/thoraxjnl-2021-217915

August 20, 2021

Chronic obstructive pulmonary disease
Eosinophilia and fractional exhaled nitric oxide levels in chronic obstructive lung disease

Srinadh Annangi, Snigdha Nutalapati, Jamie Sturgill, Eric Flenaugh, Marilyn Foreman

doi: 10.1136/thoraxjnl-2020-214644
Chronic obstructive pulmonary disease
Airflow obstruction, impaired lung function and risk of sudden cardiac death: a prospective cohort study

Yun-Jiu Cheng, Zhen-Guang Chen, Feng-Juan Yao, Li-Juan Liu, Ming Zhang, Su-Hua Wu

doi: 10.1136/thoraxjnl-2020-215632
Editorial
CHK yourself, before you wreck yourself: targeting the DNA damage response in secondary pulmonary hypertension

Andrew Bryant, Vinicio de Jesus Perez

doi: 10.1136/thoraxjnl-2021-217882

August 17, 2021

Lung cancer
Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review

Helen Hall, Adam Tocock, Sarah Burdett, David Fisher, William M Ricketts, John Robson, Thomas Round, Sarita Gorolay, Emma MacArthur, Donna Chung, Sam M Janes, Michael D Peake, Neal Navani

doi: 10.1136/thoraxjnl-2021-216865

August 16, 2021

Interstitial lung disease
Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis

Amit Kumar, Evan Elko, Sierra R Bruno, Zoe F Mark, Nicolas Chamberlain, Bethany Korwin Mihavics, Ravishankar Chandrasekaran, Joseph Walzer, Mona Ruban, Clarissa Gold, Ying Wai Lam, Sudhir Ghandikota, Anil G Jegga, Jose L Gomez, Yvonne MW Janssen-Heininger, Vikas Anathy

doi: 10.1136/thoraxjnl-2021-216882

August 05, 2021

Images in Thorax
Bronchoscopic extraction of a migrated endovascular coil
Free

John Doan, Kavya Puchhalapalli, Parag J Patel, Mario Gasparri, Jonathan S Kurman, Bryan S Benn

doi: 10.1136/thoraxjnl-2021-216873
Images in Thorax
Periodic breathing during hypoxia altitude simulation test
Free

Santiago C. Arce, Guillermo B. Semeniuk, Eduardo L. De Vito

doi: 10.1136/thoraxjnl-2021-217320
Images in Thorax
Atypical cause of bronchial cut-off sign
Free

Brian Gaffney, Liam Chawke, Michaela Larkin, Gaith Qsous, David Healy, Michael P Keane, Aurélie Fabre, David J Murphy, Cormac McCarthy

doi: 10.1136/thoraxjnl-2021-217708

July 26, 2021

Rehabilitation
A telerehabilitation programme in post-discharge COVID-19 patients (TERECO): a randomised controlled trial

Jian'an Li, Wenguang Xia, Chao Zhan, Shouguo Liu, Zhifei Yin, Jiayue Wang, Yufei Chong, Chanjuan Zheng, Xiaoming Fang, Wei Cheng, Jan D Reinhardt

doi: 10.1136/thoraxjnl-2021-217382

July 23, 2021

Paediatric lung disease
Association of the dysfunctional placentation endotype of prematurity with bronchopulmonary dysplasia: a systematic review, meta-analysis and meta-regression

Maria Pierro, Eduardo Villamor-Martinez, Elke van Westering-Kroon, Maria Alvarez-Fuente, Steven H Abman, Eduardo Villamor

doi: 10.1136/thoraxjnl-2020-216485

July 22, 2021

Respiratory epidemiology
Associations of ultrafine and fine particles with childhood emergency room visits for respiratory diseases in a megacity

Jiakun Fang, Xiaoming Song, Hongbing Xu, Rongshan Wu, Jing Song, Yunfei Xie, Xin Xu, Yueping Zeng, Tong Wang, Yutong Zhu, Ningman Yuan, Jinzhu Jia, Baoping Xu, Wei Huang

doi: 10.1136/thoraxjnl-2021-217017

July 19, 2021

Lung cancer
International differences in lung cancer survival by sex, histological type and stage at diagnosis: an ICBP SURVMARK-2 Study

Marzieh Araghi, Miranda Fidler-Benaoudia, Melina Arnold, Mark Rutherford, Aude Bardot, Jacques Ferlay, Oliver Bucher, Prithwish De, Gerda Engholm, Anna Gavin, Serena Kozie, Alana Little, Bjørn Møller, Nathalie St Jacques, Hanna Tervonen, Paul Walsh, Ryan Woods, Dianne L O'Connell, David Baldwin, Mark Elwood, Sabine Siesling, Freddie Bray, Isabelle Soerjomataram, ICBP SURVMARK-2 Local Leads, ICBP SURVMARK-2 Academic Reference Group ICBP Clinical Committee–Lung

doi: 10.1136/thoraxjnl-2020-216555

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November 04, 2021

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October 29, 2021

October 27, 2021

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October 21, 2021

October 16, 2021

October 14, 2021

October 06, 2021

October 04, 2021

September 30, 2021

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