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Online First

May 25, 2022

Interstitial lung disease
Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

Luke M Kraven, Adam R Taylor, Philip L Molyneaux, Toby M Maher, John E McDonough, Marco Mura, Ivana V Yang, David A Schwartz, Yong Huang, Imre Noth, Shwu Fan Ma, Astrid J Yeo, William A Fahy, R Gisli Jenkins, Louise V Wain

doi: 10.1136/thoraxjnl-2021-218563
Critical care
Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39

Shilpa Tiwari-Heckler, Ghee Rye Lee, James Harbison, Carola Ledderose, Eva Csizmadia, David Melton, Quanzhi Zhang, Wolfgang Junger, Guanqing Chen, Carl J Hauser, Leo E Otterbein, Maria Serena Longhi, Simon Christopher Robson

doi: 10.1136/thoraxjnl-2021-218047

May 17, 2022

Critical care
High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial
Free

Claudia Crimi, Alberto Noto, Fabiana Madotto, Mariachiara Ippolito, Santi Nolasco, Raffaele Campisi, Stefano De Vuono, Giuseppe Fiorentino, Ioannis Pantazopoulos, Athanasios Chalkias, Alessandro Libra, Alessio Mattei, Raffaele Scala, Enrico M Clini, Begum Ergan, Manel Lujan, Joao Carlos Winck, Antonino Giarratano, Annalisa Carlucci, Cesare Gregoretti, Paolo Groff, Andrea Cortegiani on behalf of the COVID-HIGH Investigators

doi: 10.1136/thoraxjnl-2022-218806
Respiratory research
Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant

Motaharehsadat Heydarian, Prajakta Oak, Xin Zhang, Nona Kamgari, Alida Kindt, Markus Koschlig, Tina Pritzke, Erika Gonzalez-Rodriguez, Kai Förster, Rory E Morty, Friederike Häfner, Christoph Hübener, Andreas W Flemmer, Ali Oender Yildirim, Deepti Sudheendra, Xuefei Tian, Agnese Petrera, Holger Kirsten, Peter Ahnert, Nick Morrell, Tushar J Desai, Jennifer Sucre, Edda Spiekerkoetter, Anne Hilgendorff

doi: 10.1136/thoraxjnl-2021-218083

May 12, 2022

Pulmonary puzzle
COPD in the chromosomes

Beatrice Cockbain, Deborah Morris-Rosendahl, Adele Corrigan, Matthew David Hind

doi: 10.1136/thoraxjnl-2022-218782

May 10, 2022

Respiratory epidemiology
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease

Anna Guyatt, Catherine John, Alexander T Williams, Nick Shrine, Nicola F Reeve, SpiroMeta consortium, Ian Sayers, Ian Hall, Louise V Wain, Nuala Sheehan, Frank Dudbridge, Martin D Tobin

doi: 10.1136/thoraxjnl-2021-217993

May 09, 2022

Brief communication
COVID-19-related changes in outpatient CPAP setup pathways for OSA are linked with decreased 30-day CPAP usage
Free

Chris D Turnbull, Martin Allen, Jennifer Appleby, Richard Brown, Nathalie Bryan, Ann Cooper, Brendan G Cooper, Cathie Gillooly, James Davidson, Hannah Farley, Ana Gaspar, Gillian Gibbons, Beverley Gray, Graham Hill, Adrian Kendrick, Blake Marsh, Alison McMillan, Joseph Page, Justin Charles Thane Pepperell, Tim Quinnell, Chris Rogers, Jane Sexton, Naomi Sheperd, Joerg Steier, James Stockley, John Stradling, Asia Woroszyl, Sophie West, Susan Wright, Annabel Nickol

doi: 10.1136/thoraxjnl-2021-218635

May 02, 2022

Asthma
Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma

Alberta L Wang, Lies Lahousse, Amber Dahlin, Ahmed Edris, Michael McGeachie, Sharon M Lutz, Joanne E Sordillo, Guy Brusselle, Jessica Lasky-Su, Scott T Weiss, Carlos Iribarren, Meng X Lu, Kelan G Tantisira, Ann C Wu

doi: 10.1136/thoraxjnl-2021-217674

April 28, 2022

Case based discussion
72-year-old woman with dyspnoea and pulmonary artery filling defects on CT angiogram

Wei Qin, Ziyang Zhu, Qiong Liu, Shi Chen, Fajiu Li, Chenghong Li

doi: 10.1136/thoraxjnl-2022-218749
Brief communication
Ninety-day mortality following lung cancer surgery: outcomes from the English national clinical outcomes audit

Helen Morgan, David Baldwin, Richard Hubbard, Neal Navani, Doug West, Emma Louise O'Dowd

doi: 10.1136/thoraxjnl-2021-218308
Respiratory research
Effects of traditional mind–body movement therapy on chronic cardiopulmonary dyspnoea: a systematic review and meta-analysis

Tiange Zhang, Rui Zhou, Ting Wang, Yijun Xin, Xiaohong Liu, Huiting Huang

doi: 10.1136/thoraxjnl-2021-218030

April 27, 2022

Asthma
Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS

Subhabrata Moitra, Anne-Elie Carsin, Michael J Abramson, Simone Accordini, Andre F S Amaral, Josep Anto, Roberto Bono, Lidia Casas Ruiz, Isa Cerveri, Leda Chatzi, Pascal Demoly, Sandra Dorado-Arenas, Bertil Forsberg, Frank Gilliland, Thorarinn Gislason, Jose A Gullón, Joachim Heinrich, Mathias Holm, Christer Janson, Rain Jogi, Francisco Gómez Real, Debbie Jarvis, Bénédicte Leynaert, Dennis Nowak, Nicole Probst-Hensch, José Luis Sánchez-Ramos, Chantal Raherison-Semjen, Valerie Siroux, Stefano Guerra, Manolis Kogevinas, Judith Garcia-Aymerich

doi: 10.1136/thoraxjnl-2021-217867

April 26, 2022

Respiratory infection
High prevalence of multiple serotypes of pneumococci in patients with pneumonia and their associated risk factors

Bhim Gopal Dhoubhadel, Motoi Suzuki, Tomoko Ishifuji, Makito Yaegashi, Norichika Asoh, Masayuki Ishida, Sugihiro Hamaguchi, Masahiro Aoshima, Michio Yasunami, Koya Ariyoshi, Konosuke Morimoto Adult Pneumonia Study Group-Japan (APSG-J)

doi: 10.1136/thoraxjnl-2021-217979

April 25, 2022

Cystic fibrosis
Longitudinal lung clearance index and association with structural lung damage in children with cystic fibrosis

Marcus Svedberg, Henrik Imberg, Per Magnus Gustafsson, Harm Tiddens, Gwyneth Davies, Anders Lindblad

doi: 10.1136/thoraxjnl-2021-218178
Editorial
Back to basics: the respiratory management of Duchenne muscular dystrophy

David J Birnkrant, John C Carter

doi: 10.1136/thoraxjnl-2022-218798

April 22, 2022

Brief communication
COVID-19 associated phrenic nerve mononeuritis: a case series
Free

Sheonagh MacPhail Law, Kathryn Scott, Ahmed Alkarn, Aisha Mahjoub, Arup K Mallik, Giles Roditi, Brian Choo-Kang

doi: 10.1136/thoraxjnl-2021-218257
Environmental exposure
Ambient heat exposure and COPD hospitalisations in England: a nationwide case-crossover study during 2007–2018

Garyfallos Konstantinoudis, Cosetta Minelli, Ana Maria Vicedo-Cabrera, Joan Ballester, Antonio Gasparrini, Marta Blangiardo

doi: 10.1136/thoraxjnl-2021-218374
Paediatric lung disease
Bronchopulmonary dysplasia and expiratory airflow at 8 years in children born extremely preterm in the post-surfactant era

Lex William Doyle, Sarath Ranganathan, Jeanie Cheong The Victorian Infant Collaborative Study Group

doi: 10.1136/thoraxjnl-2022-218792

April 21, 2022

Chronic obstructive pulmonary disease
Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD: a randomised controlled trial

Marc Spielmanns, Rainer Gloeckl, Inga Jarosch, Daniela Leitl, Tessa Schneeberger, Tobias Boeselt, Stephan Huber, Pawandeep Kaur-Bollinger, Bernhard Ulm, Claudia Mueller, Jonas Bjoerklund, Sabine Spielmanns, Wolfram Windisch, Anna-Maria Pekacka-Egli, Andreas Rembert Koczulla

doi: 10.1136/thoraxjnl-2021-218338
Lung cancer
Impact of time-to-treatment on survival for advanced non-small cell lung cancer patients in the Netherlands: a nationwide observational cohort study

Sosse E Klarenbeek, Mieke J Aarts, Michel M van den Heuvel, Mathias Prokop, Marcia Tummers, Olga C J Schuurbiers

doi: 10.1136/thoraxjnl-2021-218059
Respiratory infection
Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1β in Klebsiella-mediated acute respiratory distress syndrome

Li-Tzu Wang, B Linju Yen, Hsiu-Huan Wang, Ying-Yin Chao, Wei Lee, Li-Yueh Huang, Sheng-Kang Chiu, L. Kristopher Siu, Ko-Jiunn Liu, Huey-Kang Sytwu, Men-Luh Yen

doi: 10.1136/thoraxjnl-2021-217928
Lung transplantation
Altered purine metabolism at reperfusion affects clinical outcome in lung transplantation

Cristina Baciu, Jason Shin, Michael Hsin, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu

doi: 10.1136/thoraxjnl-2021-217498
Images in Thorax
Customised Y-shaped self-expandable covered metallic stent with a dead end for the treatment of bronchopleural fistula
Free

Yahua Li, Yiyang Liu, Kewei Ren, Xinwei Han, Jianzhuang Ren

doi: 10.1136/thoraxjnl-2021-218080

April 15, 2022

Cystic fibrosis
Evaluation of clinically relevant changes in the lung clearance index in children with cystic fibrosis and healthy controls

Lucy Perrem, Sanja Stanojevic, Melinda Solomon, Hartmut Grasemann, Neil Sweezey, Valerie Waters, Don B Sanders, Stephanie D Davis, Felix Ratjen

doi: 10.1136/thoraxjnl-2021-218347

April 11, 2022

Thoracic surgery
Cytoreductive surgery with hyperthermic intrathoracic chemotherapy for malignant pleural mesothelioma: a systematic review

Alan G. Dawson, Kudzayi Kutywayo, Seid B. Mohammed, Dean A. Fennell, Apostolos Nakas

doi: 10.1136/thoraxjnl-2021-218214
Paediatric lung disease
Tracking of lung function from 10 to 35 years after being born extremely preterm or with extremely low birth weight

Tonje Bårdsen, Ola Drange Røksund, Merete Røineland Benestad, Karl Ove Hufthammer, Hege Havstad Clemm, Ingvild Bruun Mikalsen, Knut Øymar, Trond Markestad, Thomas Halvorsen, Maria Vollsæter

doi: 10.1136/thoraxjnl-2021-218400
Editorial
Extreme prematurity and adult respiratory disease

Warren Lenney, Neil Marlow

doi: 10.1136/thoraxjnl-2021-218599

April 07, 2022

Lung cancer
Selection of eligible participants for screening for lung cancer using primary care data

Emma L O'Dowd, Kevin ten Haaf, Jaspreet Kaur, Stephen W Duffy, William Hamilton, Richard B Hubbard, John K Field, Matthew EJ Callister, Sam M Janes, Harry J de Koning, Janette Rawlinson, David R Baldwin

doi: 10.1136/thoraxjnl-2021-217142
Images in Thorax
Massive colothorax secondary to intestinal pseudo-obstruction: an unusual cause of respiratory failure
Free

Benjamin Pippard, Laura Clarke, Victor Chew, Kevin Conroy, Julia Dunleavy

doi: 10.1136/thoraxjnl-2021-218282

April 05, 2022

Lung transplantation
Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction

Nicholas A Kolaitis, Ying Gao, Allison Soong, John R Greenland, Steven R Hays, Jeffrey A Golden, Aida Venado, Lorriana E Leard, Rupal J Shah, Mary Ellen Kleinhenz, Patricia P Katz, Jasleen Kukreja, Paul D Blanc, Patrick J Smith, Jonathan Paul Singer

doi: 10.1136/thoraxjnl-2021-217612

March 31, 2022

Environmental exposure
Short-term exposure to ambient air pollution and individual emergency department visits for COVID-19: a case-crossover study in Canada

Eric Lavigne, Niilo Ryti, Antonio Gasparrini, Francesco Sera, Scott Weichenthal, Hong Chen, Teresa To, Greg J Evans, Liu Sun, Aman Dheri, Lionnel Lemogo, Serge Olivier Kotchi, Dave Stieb

doi: 10.1136/thoraxjnl-2021-217602
Tuberculosis
Airflow obstruction and small airway dysfunction following pulmonary tuberculosis: a cross-sectional survey

Zhenzhen Xing, Tieying Sun, Jean-Paul Janssens, Di Chai, Weiming Liu, Yaqi Tong, Yuxia Wang, Yali Ma, Mingming Pan, Jia Cui, Chen Wang, YanFei Guo

doi: 10.1136/thoraxjnl-2021-218345

March 30, 2022

Smoking
Cigarette smoking is a secondary cause of folliculin loss

Xiuying Li, Yandong Lai, Zachary Lane, Hilary Strollo, Kazuya Tanimura, John C Sembrat, Chunbin Zou, Michael M Myerburg, Mauricio Rojas, Steven Shapiro, Yu Jiang, Toru Nyunoya

doi: 10.1136/thoraxjnl-2021-217197
Asthma
Relationship between asthma and severe COVID-19: a national cohort study

Ted Dolby, Vahe Nafilyan, Ann Morgan, Constantinos Kallis, Aziz Sheikh, Jennifer K Quint

doi: 10.1136/thoraxjnl-2021-218629
Respiratory research
Cost-effectiveness of ambulatory care management of primary spontaneous pneumothorax: an open-label, randomised controlled trial

Ramon Luengo-Fernandez, Filipa Landeiro, Rob Hallifax, Najib M Rahman

doi: 10.1136/thoraxjnl-2021-218479
Brief communication
Impact of antifibrotic therapy on lung cancer development in idiopathic pulmonary fibrosis

Hyogo Naoi, Yuzo Suzuki, Kazutaka Mori, Yuya Aono, Masato Kono, Hirotsugu Hasegawa, Koshi Yokomura, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Hidenori Nakamura, Takafumi Suda

doi: 10.1136/thoraxjnl-2021-218281
Respiratory infection
Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis

Yandong Lai, Xiuying Li, Tiao Li, Xiaoyun Li, Toru Nyunoya, Kong Chen, Georgios Kitsios, Mehdi Nouraie, Yingze Zhang, Bryan J McVerry, Janet S Lee, Rama K Mallmapalli, Chunbin Zou

doi: 10.1136/thoraxjnl-2021-217526
Brief communication
Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Linzy Houchen-Wolloff, Krisnah Poinasamy, Kate Holmes, Maryrose Tarpey, Claire Hastie, Kelly Raihani, Natalie Rogers, Nikki Smith, Dawn Adams, Paul Burgess, Jean Clark, Clare Cranage, Mahadev Desai, Nicola Geary, Rhyan Gill, Jitendra Mangwani, Lily Staunton, Colin Berry, Charlotte E Bolton, Trudie Chalder, James Chalmers, Anthony De Soyza, Omer Elneima, John Geddes, Simon Heller, Ling-Pei Ho, Joseph Jacob, Hamish McAuley, Aarti Parmar, Jennifer K Quint, Betty Raman, Matthew Rowland, Amisha Singapuri, Sally J Singh, David Thomas, Mark R Toshner, Louise V Wain, Alex Robert Horsley, Michael Marks, Christopher E Brightling, Rachael A Evans

doi: 10.1136/thoraxjnl-2021-218582

March 25, 2022

Interstitial lung disease
Parenchymal lung abnormalities following hospitalisation for COVID-19 and viral pneumonitis: a systematic review and meta-analysis
Free

Laura Fabbri, Samuel Moss, Fasihul A Khan, Wenjie Chi, Jun Xia, Karen Robinson, Alan Robert Smyth, Gisli Jenkins, Iain Stewart

doi: 10.1136/thoraxjnl-2021-218275

March 24, 2022

Interstitial lung disease
Derivation and validation of a simple multidimensional index incorporating exercise capacity parameters for survival prediction in idiopathic pulmonary fibrosis

Abhimanyu Chandel, Jean Pastre, Solène Valery, Christopher S King, Steven D Nathan

doi: 10.1136/thoraxjnl-2021-218440
Critical care
Evaluation of a health and social care programme to improve outcomes following critical illness: a multicentre study

Philip Henderson, Tara Quasim, Martin Shaw, Pamela MacTavish, Helen Devine, Malcolm Daniel, Fiona Nicolson, Peter O’Brien, Ashley Weir, Laura Strachan, Lorraine Senior, Phil Lucie, Lynn Bollan, Jane Duffty, Lucy Hogg, Colette Ross, Malcolm Sim, Radha Sundaram, Theodore J Iwashyna, Joanne McPeake

doi: 10.1136/thoraxjnl-2021-218428

March 23, 2022

Critical care
Thoracic ultrasound influences physiotherapist’s clinical decision-making in respiratory management of critical care patients: a multicentre cohort study

Aymeric Le Neindre, Louise Hansell, Johan Wormser, Andreia Gomes Lopes, Carlos Diaz Lopez, Christophe Romanet, Gerald Choukroun, Maxime Nguyen, François Philippart, Pierre-Grégoire Guinot, Hergen Buscher, Bélaid Bouhemad, George Ntoumenopoulos

doi: 10.1136/thoraxjnl-2021-218217

March 21, 2022

Editorial
Childhood Interstitial Lung Disease (chILD): shining a new light on childhood!

Alicia Casey, Robin Deterding

doi: 10.1136/thoraxjnl-2022-218727

March 18, 2022

Images in Thorax
Opportunistic actinomycosis in pulmonary alveolar proteinosis
Free

Sze Shyang Kho, Suhashini Ganapaty, Noorjehan Omar, Shang Ze Tan, Mona Zaria Nasarudin, Jamalul Azizi Abdul Rahaman

doi: 10.1136/thoraxjnl-2021-217940
Sleep
Cardiovascular outcomes in obstructive sleep apnoea and implications of clinical phenotyping on effect of CPAP treatment

Pei-Hang Xu, Daniel Y T Fong, Macy M S Lui, David C L Lam, Mary Sau Man Ip

doi: 10.1136/thoraxjnl-2021-217714

March 11, 2022

Respiratory research
Nationwide indoor smoking ban and impact on smoking behaviour and lung function: a two-population natural experiment

Alexandra Strassmann, Yunus Çolak, Miquel Serra-Burriel, Børge G Nordestgaard, Alexander Turk, Shoaib Afzal, Milo A Puhan

doi: 10.1136/thoraxjnl-2021-218436
Brief communication
Pulmonary tuberculosis associated with immune checkpoint inhibitors: a pharmacovigilance study

Jianhong Zhu, Zhichao He, Dan Liang, Xiaoxia Yu, Kaifeng Qiu, Junyan Wu

doi: 10.1136/thoraxjnl-2021-217575

March 04, 2022

Editorial
Limited side effects of asthma treatment on growth and bone health in children

Marie Standl

doi: 10.1136/thoraxjnl-2021-218531

March 02, 2022

Paediatric lung disease
Routine lung volume recruitment in boys with Duchenne muscular dystrophy: a randomised clinical trial

Sherri L Katz, Jean K Mah, Hugh J McMillan, Craig Campbell, Vid Bijelić, Nick Barrowman, Franco Momoli, Henrietta Blinder, Shawn D Aaron, Laura C McAdam, The Thanh Diem Nguyen, Mark Tarnopolsky, David F Wensley, David Zielinski, Louise Rose, Nicole Sheers, David J Berlowitz, Lisa Wolfe, Doug McKim

doi: 10.1136/thoraxjnl-2021-218196
Asthma
Long-term exposure to ambient air pollution and asthma symptom score in the CONSTANCES cohort

Marion Keirsbulck, Marine Savouré, Emeline Lequy, Jie Chen, Kees de Hoogh, Danielle Vienneau, Marcel Goldberg, Marie Zins, Nicolas Roche, Rachel Nadif, Benedicte Jacquemin

doi: 10.1136/thoraxjnl-2021-218344

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