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Online First

March 16, 2023

Environmental exposure
Activation of epithelial and inflammatory pathways in adolescent elite athletes exposed to intense exercise and air pollution

Janne Goossens, Anne-Charlotte Jonckheere, Sven F Seys, Ellen Dilissen, Tatjana Decaesteker, Camille Goossens, Koen Peers, Vincent Vanbelle, Jeroen Stappers, Sven Aertgeerts, Barbara De Wilde, Jasmine Leus, Sophie Verelst, Marc Raes, Lieven Dupont, Dominique M Bullens

doi: 10.1136/thorax-2022-219651

March 02, 2023

Editorial
ICS/formoterol maintenance and reliever therapy: how far beyond asthma?

Richard Beasley, Pepa Bruce, Lee Hatter

doi: 10.1136/thorax-2022-219979
Editorial
ATP binding cassette member A3 (ABCA3): coming of age

Alicia Casey, Lawrence Nogee, Jennifer Wambach

doi: 10.1136/thorax-2022-219972

February 23, 2023

Brief communication
Cost-effectiveness of home non-invasive ventilation in patients with persistent hypercapnia after an acute exacerbation of COPD in the UK

Patrick Brian Murphy, Bernd Brueggenjuergen, Thomas Reinhold, Qing Gu, Laura Fusfeld, Gerard Criner, Thomas F Goss, Nicholas Hart

doi: 10.1136/thorax-2022-219653
Respiratory research
Not all vaping is the same: differential pulmonary effects of vaping cannabidiol versus nicotine

Tariq A Bhat, Suresh G Kalathil, Maciej L Goniewicz, Alan Hutson, Yasmin Thanavala

doi: 10.1136/thorax-2022-218743

February 20, 2023

Interstitial lung disease
Topological data analysis identifies molecular phenotypes of idiopathic pulmonary fibrosis

Andrew Shapanis, Mark G Jones, James Schofield, Paul Skipp

doi: 10.1136/thorax-2022-219731
Orphan lung disease
ABCA3-related interstitial lung disease beyond infancy

Yang Li, Elias Seidl, Katrin Knoflach, Florian Gothe, Maria Elisabeth Forstner, Katarzyna Michel, Ingo Pawlita, Florian Gesenhues, Franziska Sattler, Xiaohua Yang, Carolin Kroener, Simone Reu-Hofer, Julia Ley-Zaporozhan, Birgit Kammer, Ingrid Krüger-Stollfuß, Julien Dinkel, Julia Carlens, Martin Wetzke, Antonio Moreno-Galdó, Alba Torrent-Vernetta, Joanna Lange, Katarzyna Krenke, Nisreen Rumman, Sarah Mayell, Tugba Sismanlar, Ayse Aslan, Nicolas Regamey, Marijke Proesmans, Florian Stehling, Lutz Naehrlich, Kilinc Ayse, Sebastian Becker, Cordula Koerner-Rettberg, Erika Plattner, Effrosyni D Manali, Spyridon A Papiris, Ilaria Campo, Matthias Kappler, Nicolaus Schwerk, Matthias Griese

doi: 10.1136/thorax-2022-219434
Images in Thorax
Rare cause of massive haemoptysis diagnosed by ultrasonography in the ICU
Free

Wincy Wing Sze Ng, Kevin Chin, Sin Man Lam

doi: 10.1136/thorax-2022-219559
Editorial
Do people living with HIV have accelerated lung function decline, despite adequate treatment?

Sheikh M Alif, Muhammad Aziz Rahman

doi: 10.1136/thorax-2023-220011
Paediatric lung disease
Tracheostomy in children is associated with neutrophilic airway inflammation

Jason Powell, Steven Powell, Michael W Mather, Lauren Beck, Andrew Nelson, Pawel Palmowski, Andrew Porter, Jonathan Coxhead, Ann Hedley, Jonathan Scott, Anthony J Rostron, Thomas P Hellyer, Fatima Zaidi, Tracey Davey, James P Garnett, Rachel Agbeko, Chris Ward, Christopher J Stewart, Clifford C Taggart, Malcolm Brodlie, A John Simpson

doi: 10.1136/thorax-2022-219557
Images in Thorax
Tracheal stenosis after endobronchial ultrasound-guided transbronchial needle aspiration
Free

Andrea Grau, Carme Lozano, Miguel Gallego

doi: 10.1136/thorax-2022-219949

February 08, 2023

Images in Thorax
Invasive pulmonary infection caused by Trichoderma longibrachiatum
Free

Saibin Wang, Junwei Tu

doi: 10.1136/thorax-2022-219855

February 02, 2023

Respiratory epidemiology
Air pollution associated with incidence and progression trajectory of chronic lung diseases: a population-based cohort study

Xiaojie Wang, Lan Chen, Miao Cai, Fei Tian, Hongtao Zou, Zhengmin (Min) Qian, Zilong Zhang, Haitao Li, Chongjian Wang, Steven W Howard, Yang Peng, Li’e Zhang, Elizabeth Bingheim, Hualiang Lin, Yunfeng Zou

doi: 10.1136/thorax-2022-219489

February 01, 2023

Paediatric lung disease
Characterising airway obstructive, dysanaptic and PRISm phenotypes of prematurity-associated lung disease

Michael Cousins, Kylie Hart, Sarah J Kotecha, A John Henderson, W John Watkins, Andrew Bush, Sailesh Kotecha

doi: 10.1136/thorax-2022-219301
Chronic obstructive pulmonary disease
Budesonide/formoterol maintenance and reliever therapy versus fluticasone/salmeterol fixed-dose treatment in patients with COPD

Susan Muiser, Kai Imkamp, Dianne Seigers, Nynke J Halbersma, Judith M Vonk, Bart H D Luijk, Gert-Jan Braunstahl, Jan-Willem van den Berg, Bart-Jan Kroesen, Janwillem W H Kocks, Irene H Heijink, Helen K Reddel, Huib A M Kerstjens, Maarten van den Berge

doi: 10.1136/thorax-2022-219620

January 31, 2023

Editorial
Elucidating minimal important difference in childhood interstitial lung diseases

Silvija-Pera Jerkic, Johannes Schulze

doi: 10.1136/thorax-2022-219907

January 30, 2023

Sleep
Association of clinically significant obstructive sleep apnoea with risks of contracting COVID-19 and serious COVID-19 complications: a retrospective population-based study of health administrative data
Free

Tetyana Kendzerska, Marcus Povitz, Andrea S Gershon, Clodagh M Ryan, Robert Talarico, Dennys Andrea Franco Avecilla, Rebecca Robillard, Najib T Ayas, Sachin R Pendharkar

doi: 10.1136/thorax-2022-219574
Images in Thorax
When is a lung abscess not a lung abscess? Recurrent pneumonia and empyema associated with intrapulmonary cystic teratoma
Free

Catherine Penman, Giles Dixon, Richard Daly, Andrew Low

doi: 10.1136/thorax-2022-219617

January 25, 2023

Editorial
Should we retain smaller growing nodules in lung cancer screening programmes for surveillance?

Mamta Ruparel

doi: 10.1136/thorax-2022-219838

January 13, 2023

Chronic obstructive pulmonary disease
Faster lung function decline in people living with HIV despite adequate treatment: a longitudinal matched cohort study

Rebekka Faber Thudium, Andreas Ronit, Shoaib Afzal, Yunus Çolak, Julie Lyng Forman, Fernando Mendo, Fabian Chen, Vicente Estrada, Nagalingeswaran Kumarasamy, Børge G Nordestgaard, Jens Lundgren, Jørgen Vestbo, Ken M Kunisaki, Susanne Dam Nielsen for the COCOMO, INSIGHT START Pulmonary Substudy and CGPS Study Groups

doi: 10.1136/thorax-2022-218910

January 12, 2023

Respiratory epidemiology
COPD in Africa: risk factors, hospitalisation, readmission and associated outcomes—a systematic review and meta-analysis

Chidiamara Maria Njoku, John R Hurst, Leigh Kinsman, Saliu Balogun, Kehinde Obamiro

doi: 10.1136/thorax-2022-218675

December 30, 2022

Asthma
Observational UK cohort study to describe intermittent oral corticosteroid prescribing patterns and their association with adverse outcomes in asthma

Heath Heatley, Trung N Tran, Arnaud Bourdin, Andrew Menzies-Gow, David J Jackson, Ekaterina Maslova, Jatin Chapaneri, Derek Skinner, Victoria Carter, Jeffrey Shi Kai Chan, Con Ariti, John Haughney, David B Price

doi: 10.1136/thorax-2022-219642
Asthma
Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)
Free

Florence Tydeman, Paul E Pfeffer, Giulia Vivaldi, Hayley Holt, Mohammad Talaei, David Jolliffe, Gwyneth Davies, Ronan A Lyons, Christopher Griffiths, Frank Kee, Aziz Sheikh, Seif O Shaheen, Adrian R Martineau

doi: 10.1136/thorax-2022-219591

December 26, 2022

Paediatric lung disease
Minimal important difference in childhood interstitial lung diseases

Matthias Griese, Nicolaus Schwerk, Julia Carlens, Martin Wetzke, Nagehan Emiralioğlu, Nural Kiper, Joanna Lange, Katarzyna Krenke, chILD collaborators, Elias Seidl

doi: 10.1136/thorax-2022-219206
Chronic obstructive pulmonary disease
Brain activity measured by functional brain imaging predicts breathlessness improvement during pulmonary rehabilitation

Sarah L Finnegan, Michael Browning, Eugene Duff, Catherine J Harmer, Andrea Reinecke, Najib M Rahman, Kyle T S Pattinson

doi: 10.1136/thorax-2022-218754

December 08, 2022

Occupational lung disease
Rate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers

Danila Azzolina, Dario Consonni, Daniela Ferrante, Dario Mirabelli, Stefano Silvestri, Ferdinando Luberto, Alessia Angelini, Francesco Cuccaro, Anna Maria Nannavecchia, Enrico Oddone, Massimo Vicentini, Francesco Barone-Adesi, Tiziana Cena, Lucia Mangone, Francesca Roncaglia, Orietta Sala, Simona Menegozzo, Roberta Pirastu, Sara Tunesi, Elisabetta Chellini, Lucia Miligi, Patrizia Perticaroli, Aldo Pettinari, Vittoria Bressan, Enzo Merler, Paolo Girardi, Lucia Bisceglia, Alessandro Marinaccio, Stefania Massari, Corrado Magnani The working group

doi: 10.1136/thorax-2021-217862

December 01, 2022

Lung cancer
Airflow limitation and mortality during cancer screening in the National Lung Screening Trial: why quantifying airflow limitation matters

Robert P Young, Ralph C Ward, Raewyn J Scott, Greg D Gamble, Gerard Silvestri

doi: 10.1136/thorax-2022-219334

November 24, 2022

Respiratory epidemiology
Mortality in non-exacerbating COPD: a longitudinal analysis of UK primary care data

Alexandra Lenoir, Hannah Whittaker, Alicia Gayle, Debbie Jarvis, Jennifer K Quint

doi: 10.1136/thorax-2022-218724

November 11, 2022

Respiratory infection
Prognostic significance of radiological pleuroparenchymal fibroelastosis in Mycobacterium avium complex lung disease: a multicentre retrospective cohort study

Yuya Aono, Hironao Hozumi, Masato Kono, Dai Hashimoto, Hidenori Nakamura, Koshi Yokomura, Shiro Imokawa, Masahiro Shirai, Daisuke Akahori, Yusuke Inoue, Kazutaka Mori, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda

doi: 10.1136/thorax-2022-219116

November 08, 2022

Lung cancer
Impact of radiographer immediate reporting of X-rays of the chest from general practice on the lung cancer pathway (radioX): a randomised controlled trial

Nick Woznitza, Bhagabati Ghimire, Anand Devaraj, Sam M Janes, Keith Piper, Susan Rowe, Angshu Bhowmik, Natasha Hayes, Daniel Togher, Nikita Arumalla, Erik Skyllberg, Iain T H Au-Yong, Susan Geary, Bindu George, Sarah Sheard, Stephen Ellis, Zoheb Shah, Sue Maughn, Stephen W Duffy, David Baldwin

doi: 10.1136/thorax-2022-219210

November 07, 2022

Asthma
Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma

Venkata Sita Rama Raju Allam, Stelios Pavlidis, Gang Liu, Nazanin Zounemat Kermani, Jennifer Simpson, Joyce To, Sheila Donnelly, Yi-Ke Guo, Philip M Hansbro, Simon Phipps, Eric F Morand, Ratko Djukanovic, Peter Sterk, Kian Fan Chung, Ian Adcock, James Harris, Maria B Sukkar

doi: 10.1136/thorax-2021-218555

October 31, 2022

Chronic obstructive pulmonary disease
Frequency and severity of respiratory infections prior to COPD diagnosis and risk of subsequent postdiagnosis COPD exacerbations and mortality: EXACOS-UK health care data study

Hannah Whittaker, Clementine Nordon, Annalisa Rubino, Tamsin Morris, Yang Xu, Enrico De Nigris, Hana Müllerová, Jennifer K Quint

doi: 10.1136/thorax-2022-219039

October 19, 2022

Interstitial lung disease
Mediators of systemic sclerosis-associated interstitial lung disease (SSc-ILD): systematic review and meta-analyses

Aislin Fields, Koray N Potel, Rhandel Cabuhal, Buena Aziri, Iain D Stewart, Bettina C Schock

doi: 10.1136/thorax-2022-219226

October 10, 2022

Interstitial lung disease
Integrative analyses for the identification of idiopathic pulmonary fibrosis-associated genes and shared loci with other diseases

Ming Chen, Yiliang Zhang, Taylor Adams, Dingjue Ji, Wei Jiang, Louise V Wain, Michael Cho, Naftali Kaminski, Hongyu Zhao

doi: 10.1136/thorax-2021-217703

October 05, 2022

Critical care
Acute hypoxaemic respiratory failure after treatment with lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal: long-term outcomes from the REST randomised trial

Andrew J Boyle, Clíona McDowell, Ashley Agus, Danielle Logan, Jonathan D Stewart, Colette Jackson, Jeanette Mills, James J McNamee, Daniel F McAuley

doi: 10.1136/thorax-2022-218874

September 08, 2022

Asthma
Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study

Seyi Soremekun, Liam G Heaney, Derek Skinner, Lakmini Bulathsinhala, Victoria Carter, Isha Chaudhry, Naeimeh Hosseini, Neva Eleangovan, Ruth Murray, Trung N Tran, Benjamin Emmanuel, Esther Garcia Gil, Andrew Menzies-Gow, Matthew Peters, Njira Lugogo, Rupert Jones, David B Price

doi: 10.1136/thorax-2021-217032

September 07, 2022

Sleep
Randomised, controlled crossover trial of intermittent and continuous transcutaneous electrical stimulation of the genioglossus muscle for obstructive sleep apnoea

Xiaofeng Wu, Dong Zhao, Weihua Hu, Zhishui Zheng, Shiqian Zha, Qingfeng Zhang, Ke Hu

doi: 10.1136/thorax-2021-218277

September 05, 2022

Critical care
Population study on diagnosis, treatment and outcomes of critically ill patients with tuberculosis (2008–2018)

Christina So, Lowell Ling, Wai Tat Wong, Jack Zhenhe Zhang, Chun Ming Ho, Pauline Yeung Ng, Hoi Ping Shum, Alwin Wai Tak Yeung, Kai Cheuk Sin, Jacky Chan, Ka Fai Au, Ting Liong, Eunise Ho, Fu Loi Chow, Laptin Ho, Kai Man Chan, Gavin Matthew Joynt

doi: 10.1136/thorax-2022-218868

August 15, 2022

Respiratory research
Optimising breathlessness triggered services for older people with advanced diseases: a multicentre economic study (OPTBreathe)

Deokhee Yi, Charles C Reilly, Gao Wei, Irene J Higginson on behalf of OPTBreathe collaborators

doi: 10.1136/thoraxjnl-2021-218251

August 10, 2022

Respiratory research
Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis

Yue Su, Johnatas Dutra Silva, Declan Doherty, David A Simpson, Daniel J Weiss, Sara Rolandsson-Enes, Daniel F McAuley, Cecilia M O'Kane, Derek P Brazil, Anna D Krasnodembskaya

doi: 10.1136/thoraxjnl-2021-218194

August 05, 2022

Interstitial lung disease
MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study

John S Kim, Ani W Manichaikul, Eric A Hoffman, Pallavi Balte, Michaela R Anderson, Elana J Bernstein, Purnema Madahar, Elizabeth C Oelsner, Steven M Kawut, Artur Wysoczanski, Andrew F Laine, Ayodeji Adegunsoye, Jennie Z Ma, Margaret A Taub, Rasika A Mathias, Stephen S Rich, Jerome I Rotter, Imre Noth, Christine Kim Garcia, R Graham Barr, Anna J Podolanczuk

doi: 10.1136/thorax-2021-218139

July 30, 2022

Asthma
Preterm or early term birth and long-term risk of asthma into midadulthood: a national cohort and cosibling study

Casey Crump, Jan Sundquist, Kristina Sundquist

doi: 10.1136/thorax-2022-218931

July 27, 2022

Respiratory epidemiology
Patient outcomes following emergency admission to hospital for COVID-19 compared with influenza: retrospective cohort study

Thomas Woodcock, Geva Greenfield, Ajit Lalvani, Azeem Majeed, Paul Aylin

doi: 10.1136/thoraxjnl-2021-217858

July 18, 2022

Asthma
Single dose of budesonide/formoterol turbuhaler compared to salbutamol pMDI for speed of bronchodilator onset in asthma: a randomised cross-over trial

Nethmi Kearns, Mathew Williams, Pepa Bruce, Melissa Black, Ciléin Kearns, Jenny Sparks, Irene Braithwaite, Mark Weatherall, Richard Beasley

doi: 10.1136/thorax-2022-219052

July 16, 2022

Interstitial lung disease
The relationship between interstitial lung abnormalities, mortality, and multimorbidity: a cohort study

Jason Leigh Sanders, Gisli Axelsson, Rachel Putman, Aravind Menon, Josée Dupuis, Hanfei Xu, Shuai Wang, Joanne Murabito, Ramachandran Vasan, Tetsuro Araki, Mizuki Nishino, George R Washko, Hiroto Hatabu, George O'Connor, Gunnar Gudmundsson, Vilmundur Gudnason, Gary M Hunninghake

doi: 10.1136/thoraxjnl-2021-218315

July 14, 2022

Lung cancer
Effects of enhanced recovery after surgery plus pulmonary rehabilitation on complications after video-assisted lung cancer surgery: a multicentre randomised controlled trial

Yu Zheng, Mao Mao, Fang Li, Lu Wang, Xintong Zhang, Xiu Zhang, Haiming Wang, Huiqing Zhou, Meifang Ji, Yulong Wang, Liang Liu, Quan Zhu, Jan D Reinhardt, Xiao Lu

doi: 10.1136/thoraxjnl-2021-218183

July 06, 2022

Respiratory infection
C reactive protein utilisation, a biomarker for early COVID-19 treatment, improves lenzilumab efficacy: results from the randomised phase 3 ‘LIVE-AIR’ trial

Zelalem Temesgen, Colleen F Kelley, Frank Cerasoli, Adrian Kilcoyne, Dale Chappell, Cameron Durrant, Omar Ahmed, Gabrielle Chappell, Victoria Catterson, Christopher Polk, Andrew Badley, Vincent C Marconi LIVE-AIR Study Group

doi: 10.1136/thoraxjnl-2022-218744

June 10, 2022

Respiratory infection
Ultra-low-dose CT versus chest X-ray for patients suspected of pulmonary disease at the emergency department: a multicentre randomised clinical trial

Inge A H van den Berk, Maadrika M N P Kanglie, Tjitske S R van Engelen, Josje Altenburg, Jouke T Annema, Ludo F M Beenen, Bart Boerrigter, Marije K Bomers, Paul Bresser, Elvin Eryigit, Maarten Groenink, Suzanne M R Hochheimer, Frits Holleman, Jos A J Kooter, Ramon B van Loon, Mitran Keijzers, Ivo van der Lee, Paul Luijendijk, Lilian J Meijboom, Saskia Middeldorp, Laura J Schijf, Robin Soetekouw, Ralf W Sprengers, Alexander D Montauban van Swijndregt, Wouter de Monyé, Milan L Ridderikhof, Michiel M Winter, Shandra Bipat, Marcel G W Dijkgraaf, Patrick M M Bossuyt, Jan M Prins, Jaap Stoker on behalf of the OPTIMACT study group

doi: 10.1136/thoraxjnl-2021-218337

May 29, 2022

Interstitial lung disease
Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

Luke M Kraven, Adam R Taylor, Philip L Molyneaux, Toby M Maher, John E McDonough, Marco Mura, Ivana V Yang, David A Schwartz, Yong Huang, Imre Noth, Shwu Fan Ma, Astrid J Yeo, William A Fahy, R Gisli Jenkins, Louise V Wain

doi: 10.1136/thoraxjnl-2021-218563

May 10, 2022

Respiratory epidemiology
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease

Anna Guyatt, Catherine John, Alexander T Williams, Nick Shrine, Nicola F Reeve, SpiroMeta consortium, Ian Sayers, Ian Hall, Louise V Wain, Nuala Sheehan, Frank Dudbridge, Martin D Tobin

doi: 10.1136/thoraxjnl-2021-217993

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