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Online First

March 08, 2021

Brief communication
Psychological impact of genetic and clinical screening for pulmonary fibrosis on asymptomatic first-degree relatives of affected individuals

Nikkola Carmichael, Jose M Martinez Manzano, Luisa D Quesada-Arias, Sergio de Frías Poli, Maura Alvarez Baumgartner, Maria A Planchart Ferretto, Lisa DiGianni, Shannon Gampala-Sagar, Dominick A Leone, Swati Gulati, Souheil Y El-Chemaly, Hilary J Goldberg, Rachel Putman, Hiroto Hatabu, Ivan O Rosas, Gary M Hunninghake, Benjamin A Raby

doi: 10.1136/thoraxjnl-2020-216244
Rehabilitation
Efficacy of unsupervised exercise in adults with obstructive lung disease: a systematic review and meta-analysis

Daniel Taylor, Alex R Jenkins, Kate Parrott, Alex Benham, Samantha Targett, Arwel W Jones

doi: 10.1136/thoraxjnl-2020-216007

March 02, 2021

Brief communication
COPD discharge bundle and pulmonary rehabilitation referral and uptake following hospitalisation for acute exacerbation of COPD

Ruth E Barker, Samantha SC Kon, Stuart F Clarke, Jenni Wenneberg, Claire M Nolan, Suhani Patel, Jessica A Walsh, Oliver Polgar, Matthew Maddocks, Morag Farquhar, Nicholas S Hopkinson, Derek Bell, Jadwiga A Wedzicha, William D-C. Man

doi: 10.1136/thoraxjnl-2020-215464
Brief communication
The Severe Respiratory Insufficiency Application (SRI App): a pilot randomised controlled trial

Daniel Sebastian Majorski, Sarah Bettina Schwarz, Friederike Sophie Magnet, Rebar Ahmad, Tim Mathes, Wolfram Windisch

doi: 10.1136/thoraxjnl-2020-216319
Editorial
Citizen science in the time of COVID-19
Free

Linda J Birkin, Eleftheria Vasileiou, Helen Ruth Stagg

doi: 10.1136/thoraxjnl-2020-216673
Occupational lung disease
Airborne occupational exposures and the risk of developing respiratory symptoms and airway obstruction in the Lifelines Cohort Study

Md Omar Faruque, H Marike Boezen, Hans Kromhout, Roel Vermeulen, Ute Bültmann, Judith M Vonk

doi: 10.1136/thoraxjnl-2020-216721
Editorial
Vitamin D and bacterial pneumonias: the question of causality

Richard James Allen

doi: 10.1136/thoraxjnl-2020-216375

February 25, 2021

Brief communication
Bronchiectasis severity correlates with outcome in patients with primary antibody deficiency

Jimstan Periselneris, Silke Schelenz, Michael Loebinger, Patricia Macedo, Zoe Adhya, Darius Armstrong-James, W Peter Kelleher

doi: 10.1136/thoraxjnl-2020-215585
Environmental exposure
Greenness may improve lung health in low–moderate but not high air pollution areas: Seven Northeastern Cities’ study

Yang Zhou, Dinh S Bui, Jennifer L Perret, Adrian J Lowe, Caroline J Lodge, Iana Markevych, Joachim Heinrich, Michael S Bloom, Luke D Knibbs, Bin Jalaludin, Bo-Yi Yang, Hong-Yao Yu, Xiao-Wen Zeng, Yunjiang Yu, Shyamali C Dharmage, Guang-Hui Dong

doi: 10.1136/thoraxjnl-2020-214767
Brief communication
Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study

Andrew J Swift, Frederick Wilson, Marcella Cogliano, Lindsay Kendall, Faisal Alandejani, Samer Alabed, Paul Hughes, Yousef Shahin, Laura Saunders, Charlotte Oram, David Capener, Alex Rothman, Pankaj Garg, Christopher Johns, Matthew Austin, Alistair Macdonald, Jo Pickworth, Peter Hickey, Robin Condliffe, Anthony Cahn, Allan Lawrie, Jim M Wild, David G Kiely

doi: 10.1136/thoraxjnl-2020-216078
Paediatric lung disease
Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts

Patricia de Gouveia Belinelo, Adam M Collison, Vanessa E Murphy, Paul D Robinson, Kathryn Jesson, Kate Hardaker, Ediane de Queiroz Andrade, Christopher Oldmeadow, Gabriela Martins Costa Gomes, Peter D Sly, Jakob Usemann, Rhea Appenzeller, Olga Gorlanova, Oliver Fuchs, Philipp Latzin, Peter G Gibson, Urs Frey, Joerg Mattes

doi: 10.1136/thoraxjnl-2020-215526
State of the art review
Neutrophils in asthma: the good, the bad and the bacteria

Helena Crisford, Elizabeth Sapey, Geraint B Rogers, Steven Taylor, Prasad Nagakumar, Ravi Lokwani, Jodie L Simpson

doi: 10.1136/thoraxjnl-2020-215986
Respiratory infection
Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score

Juan Berenguer, Alberto M Borobia, Pablo Ryan, Jesús Rodríguez-Baño, Jose M Bellón, Inmaculada Jarrín, Jordi Carratalà, Jerónimo Pachón, Antonio J Carcas, María Yllescas, José R Arribas On behalf of the COVID-19@Spain and COVID@HULP Study Groups

doi: 10.1136/thoraxjnl-2020-216001

February 23, 2021

Critical care
Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Free

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud, Claire Grange, Hervé Lobbes, Steeve Provencher, Jean-Christophe Lega

doi: 10.1136/thoraxjnl-2020-215383
Editorial
Pulmonary fibrosis screening: quantifying the psychological impact

Chad A Newton

doi: 10.1136/thoraxjnl-2021-216863

February 18, 2021

Paediatric lung disease
Simplified bedside assessment of pulmonary gas exchange in very preterm infants at 36 weeks’ postmenstrual age

Benjamin Stoecklin, Y Jane Choi, Abhijeet Rakshasbhuvankar, Jenny Svedenkrans, Gareth Jones, Jane Pillow

doi: 10.1136/thoraxjnl-2020-214659

February 16, 2021

Lung cancer
Comparing functional decline and distress from symptoms in people with thoracic life-limiting illnesses: lung cancers and non-malignant end-stage respiratory diseases

Matilda Barnes-Harris, Samuel Allingham, Deidre Morgan, Diana Ferreira, Miriam J Johnson, Kathy Eagar, David Currow

doi: 10.1136/thoraxjnl-2020-216039
Respiratory research
Multiple breath washout (MBW) testing using sulfur hexafluoride: reference values and influence of anthropometric parameters

Frederik Trinkmann, Máté Maros, Katharina Roth, Arne Hermanns, Julia Schäfer, Joshua Gawlitza, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Felix J F Herth, Thomas Ganslandt

doi: 10.1136/thoraxjnl-2020-214717
Respiratory infection
Systematic review and meta-analysis of anakinra, sarilumab, siltuximab and tocilizumab for COVID-19
Free

Fasihul A Khan, Iain Stewart, Laura Fabbri, Samuel Moss, Karen Robinson, Alan Robert Smyth, Gisli Jenkins

doi: 10.1136/thoraxjnl-2020-215266
Environmental exposure
Association between lung function of school age children and short-term exposure to air pollution and pollen: the PARIS cohort

Hélène Amazouz, Nicolas Bougas, Michel Thibaudon, Guillaume Lezmi, Nicole Beydon, Mélisande Bourgoin-Heck, Jocelyne Just, Isabelle Momas, Fanny Rancière

doi: 10.1136/thoraxjnl-2020-215515
Respiratory epidemiology
Effect of public health interventions on COVID-19 cases: an observational study
Free

Weihong Qiu, Heng He, Peng Zhang, Wenwen Yang, Tingming Shi, Xing Wang, Ailian Chen, Li Xie, Meng Yang, Dongming Wang, Mingyan Li, Weihong Chen

doi: 10.1136/thoraxjnl-2020-215086

February 15, 2021

Editorial
COVID-19 and what comes after?
Free

Nicholas S Hopkinson, Gisli Jenkins, Nicholas Hart

doi: 10.1136/thoraxjnl-2020-216226
Chronic obstructive pulmonary disease
Role of the IL-33/ST2 axis in cigarette smoke-induced airways remodelling in chronic obstructive pulmonary disease

Qiong Huang, Chen Duo Li, Yi Ran Yang, Xiao Feng Qin, Jing Jing Wang, Xin Zhang, Xiao Nan Du, Xia Yang, Ying Wang, Lun Li, Mi Mu, Zhe Lv, Ye Cui, Kewu Huang, Chris J Corrigan, Wei Wang, Sun Ying

doi: 10.1136/thoraxjnl-2020-214712

February 12, 2021

Cystic fibrosis
Longitudinal effects of ivacaftor and medicine possession ratio in people with the Gly551Asp mutation: a 5-year study

Ruth Marian Mitchell, Andrew M Jones, Katie Stocking, Philip Foden, Peter J Barry

doi: 10.1136/thoraxjnl-2020-215556
Asthma
An enhanced care package to improve asthma management in Malawian children: a randomised controlled trial

Sarah Rylance, Beatrice Chinoko, Bright Mnesa, Chris Jewell, Jonathan Grigg, Kevin Mortimer

doi: 10.1136/thoraxjnl-2020-216065

February 11, 2021

Interstitial lung disease
Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling

Jason J Gokey, John Snowball, Jenna Green, Marion Waltamath, Jillian J Spinney, Katharine E Black, Lida P Hariri, Yan Xu, Anne Karina Perl

doi: 10.1136/thoraxjnl-2020-214986
Editorial
Moving towards a better identification and management of frailty in ICU survivors

Zafeiris Louvaris, Daniel Langer

doi: 10.1136/thoraxjnl-2020-216530
Chronic obstructive pulmonary disease
Respiratory exacerbations are associated with muscle loss in current and former smokers

Stefanie Elizabeth Mason, Rafael Moreta-Martinez, Wassim W Labaki, Matthew Strand, David Baraghoshi, Elizabeth A Regan, Jessica Bon, Ruben San Jose Estepar, Richard Casaburi, Merry-Lynn N McDonald, Harry Rossiter, Barry J Make, Mark T Dransfield, MeiLan K Han, Kendra A Young, Greg Kinney, John E Hokanson, Raul San Jose Estepar, George R Washko COPDGene Investigators

doi: 10.1136/thoraxjnl-2020-215999
Editorial
Extrathoracic muscle wasting in exacerbations of COPD: no longer outside the region of interest

Neil J Greening, Michael I Polkey, Hamish Joseph Cameron McAuley

doi: 10.1136/thoraxjnl-2020-216647
State of the art review
Severe respiratory syncytial virus disease in preterm infants: a case of innate immaturity

Jeremy Anderson, Lien Anh Ha Do, Danielle Wurzel, Zheng Quan Toh, Kim Mulholland, Daniel G Pellicci, Paul V Licciardi

doi: 10.1136/thoraxjnl-2020-216291

February 08, 2021

Smoking
Current smoking and COVID-19 risk: results from a population symptom app in over 2.4 million people
Free

Nicholas S Hopkinson, Niccolo Rossi, Julia El-Sayed_Moustafa, Anthony A Laverty, Jennifer K Quint, Maxim Freidin, Alessia Visconti, Ben Murray, Marc Modat, Sebastien Ourselin, Kerrin Small, Richard Davies, Jonathan Wolf, Tim D Spector, Claire J Steves, Mario Falchi

doi: 10.1136/thoraxjnl-2020-216422

February 05, 2021

Chronic obstructive pulmonary disease
DNA methylation is associated with airflow obstruction in patients living with HIV

Ana I Hernandez Cordero, Chen Xi Yang, Maen Obeidat, Julia Yang, Julie MacIsaac, Lisa McEwen, David Lin, Michael Kobor, Richard Novak, Fleur Hudson, Hartwig Klinker, Nila Dharan, SF Paul Man, Don D Sin, Ken Kunisaki, Janice Leung on behalf of the INSIGHT START Pulmonary and Genomic Substudy Groups

doi: 10.1136/thoraxjnl-2020-215866
Tuberculosis
Recurrent TB: a systematic review and meta-analysis of the incidence rates and the proportions of relapses and reinfections

Victor Vega, Sharon Rodríguez, Patrick Van der Stuyft, Carlos Seas, Larissa Otero

doi: 10.1136/thoraxjnl-2020-215449

February 04, 2021

Asthma
Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study

Gillian M Mahon, Gerard H Koppelman, Judith M Vonk

doi: 10.1136/thoraxjnl-2020-215232
Interstitial lung disease
Oxygen supplementation during exercise improves leg muscle fatigue in chronic fibrotic interstitial lung disease

Mathieu Marillier, Anne-Catherine Bernard, Samuel Verges, Onofre Moran-Mendoza, Denis E O'Donnell, José Alberto Neder

doi: 10.1136/thoraxjnl-2020-215135
Editorial
Task shifting: a common-sense approach in children with asthma?

Warren Lenney

doi: 10.1136/thoraxjnl-2020-216695
Brief communication
Identifying patients at risk of post-discharge complications related to COVID-19 infection
Free

Jocelin Hall, Katherine Myall, Jodie L Lam, Thomas Mason, Bhashkar Mukherjee, Alex West, Amy Dewar

doi: 10.1136/thoraxjnl-2020-215861
Asthma
Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling

Florian Dilasser, Lindsay Rose, Dorian Hassoun, Martin Klein, Morgane Rousselle, Carole Brosseau, Christophe Guignabert, Camille Taillé, Marie Christine Dombret, Leonarda Di Candia, Nicolas Heddebaut, Gregory Bouchaud, Marina Pretolani, Antoine Magnan, Gervaise Loirand, Vincent Sauzeau

doi: 10.1136/thoraxjnl-2020-216271

January 29, 2021

Brief communication
Ceramide and sphingosine-1 phosphate in COPD lungs

Evgeny V Berdyshev, Karina A Serban, Kelly S Schweitzer, Irina A Bronova, Andrew Mikosz, Irina Petrache

doi: 10.1136/thoraxjnl-2020-215892
Case based discussion
Lesson of the month: management for aspiration of a silver nitrate pencil tip during tracheostomy care

Simon Deshayes, Romain Magnier, Frédérick Rault, Sylvain Teulier, Helen Fouquet, Emmanuel Bergot, Aurélien Justet

doi: 10.1136/thoraxjnl-2020-215727

January 28, 2021

Environmental exposure
Ambient air pollution exposure and chronic bronchitis in the Lifelines cohort

Dany Doiron, Jean Bourbeau, Kees de Hoogh, Anna L Hansell

doi: 10.1136/thoraxjnl-2020-216142

January 27, 2021

Orphan lung disease
Lung clearance index predicts pulmonary exacerbations in individuals with primary ciliary dyskinesia: a multicentre cohort study

Florian Singer, Anne Schlegtendal, Sylvia Nyilas, François Vermeulen, Mieke Boon, Cordula Koerner-Rettberg

doi: 10.1136/thoraxjnl-2020-215504
Chronic obstructive pulmonary disease
BET proteins are associated with the induction of small airway fibrosis in COPD

Razia Zakarya, Yik L Chan, Sandra Rutting, Karosham Reddy, Jack Bozier, Roy R Woldhuis, Dikaia Xenaki, David Van Ly, Hui Chen, Corry-Anke Brandsma, Ian M Adcock, Brian G Oliver

doi: 10.1136/thoraxjnl-2020-215092
Respiratory infection
Renin-angiotensin system blocker and outcomes of COVID-19: a systematic review and meta-analysis
Free

Hyun Woo Lee, Chang-Hwan Yoon, Eun Jin Jang, Chang-Hoon Lee

doi: 10.1136/thoraxjnl-2020-215322
Tuberculosis
‘If not TB, what could it be?’ Chest X-ray findings from the 2016 Kenya Tuberculosis Prevalence Survey

Brenda Nyambura Mungai, Elizabeth Joekes, Enos Masini, Angela Obasi, Veronica Manduku, Beatrice Mugi, Jane Ong’angò, Dickson Kirathe, Richard Kiplimo, Joseph Sitienei, Rose Oronje, Ben Morton, Stephen Bertel Squire, Peter MacPherson IMPALA Consortium

doi: 10.1136/thoraxjnl-2020-216123
State of the art review
Asthma diagnosis: into the fourth dimension

Ran Wang, Clare S Murray, Stephen J Fowler, Angela Simpson, Hannah Jane Durrington

doi: 10.1136/thoraxjnl-2020-216421
Brief communication
Evidence for multiple cases of recurrent Legionella infection: a Danish national surveillance study

Kelsie Cassell, Charlotte Kjelsø, Daniel M Weinberger, Søren A Uldum

doi: 10.1136/thoraxjnl-2020-216344
Respiratory infection
Assessing the impact of the 13 valent pneumococcal vaccine on childhood empyema in Australia

Roxanne Strachan, Nusrat Homaira, Sean Beggs, Mejbah U Bhuiyan, Gwendolyn L Gilbert, Stephen B Lambert, Kristine Macartney, Helen Marshall, Andrew C Martin, Gabrielle B McCallum, Angela McCullagh, Tim McDonald, Peter McIntyre, Shahin Oftadeh, Sarath Ranganathan, Sadasivam Suresh, Claire E Wainwright, Angela Wilson, Melanie Wong, Thomas Snelling, Adam Jaffé

doi: 10.1136/thoraxjnl-2020-216032

January 25, 2021

Case based discussion
Asthma, ECMO and eosinophils

Tom McLellan, Chinmay Patvardhan, Doris Rassl, Huw Steven Jenkins, Martin Knolle, Muhunthan Thillai

doi: 10.1136/thoraxjnl-2020-216052

January 21, 2021

Editorial
Rejuvenating old lungs: Ain’t no tonic like a drop of retinoic

Reinoud Gosens, John-Poul Ng-Blichfeldt

doi: 10.1136/thoraxjnl-2020-216632

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