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Online First

September 15, 2022

Tuberculosis
Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: a cross-sectional comparative study

Esin Nkereuwem, Schadrac Agbla, Azeezat Sallahdeen, Olumuyiwa Owolabi, Abdou K Sillah, Monica Genekah, Abdoulie Tunkara, Sheriff Kandeh, Maryama Jawara, Lamin Saidy, Andrew Bush, Toyin Togun, Beate Kampmann

doi: 10.1136/thorax-2022-219085
Cystic fibrosis
Beyond borders: cystic fibrosis survival between Australia, Canada, France and New Zealand

Adèle Coriati, Xiayi Ma, Jenna Sykes, Sanja Stanojevic, Rasa Ruseckaite, Lydie Lemonnier, Clémence Dehillotte, Jan Tate, Catherine Ann Byrnes, Scott C Bell, Pierre Regis Burgel, Anne L Stephenson

doi: 10.1136/thorax-2022-219086

September 09, 2022

Brief communication
Exercise as airway clearance therapy (ExACT) in cystic fibrosis: a UK-based e-Delphi survey of patients, caregivers and health professionals

Zoe Louise Saynor, Steve Cunningham, Lisa Morrison, Eleanor Main, Ioannis Vogiatzis, Simon Reid, Donald Urquhart

doi: 10.1136/thorax-2022-219213

September 08, 2022

Asthma
Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study

Seyi Soremekun, Liam G Heaney, Derek Skinner, Lakmini Bulathsinhala, Victoria Carter, Isha Chaudhry, Naeimeh Hosseini, Neva Eleangovan, Ruth Murray, Trung N Tran, Benjamin Emmanuel, Esther Garcia Gil, Andrew Menzies-Gow, Matthew Peters, Njira Lugogo, Rupert Jones, David B Price

doi: 10.1136/thorax-2021-217032
Images in Thorax
Pulmonary arterio-venous malformation on endobronchial ultrasound bronchoscopy
Free

Nishant Kumar Chauhan, Rengarajan Rajagopal, Benhur Joel Shadrach, Naveen Dutt

doi: 10.1136/thorax-2022-219398
Case based discussion
Case-based discussion: neonates on extracorporeal membrane oxygenation for undiagnosed recalcitrant pulmonary hypertension—management challenges

John A King, Ajay Desai, Tom Semple, Andrew G Nicholson, Andrew Bush, Samatha Sonnappa

doi: 10.1136/thorax-2021-217857

September 07, 2022

Editorial
Implementing non-invasive ventilation at home: the frontier for chronic respiratory failure?

Mark E Howard, Anna Ridgers

doi: 10.1136/thorax-2022-219480
Sleep
Randomised, controlled crossover trial of intermittent and continuous transcutaneous electrical stimulation of the genioglossus muscle for obstructive sleep apnoea

Xiaofeng Wu, Dong Zhao, Weihua Hu, Zhishui Zheng, Shiqian Zha, Qingfeng Zhang, Ke Hu

doi: 10.1136/thorax-2021-218277
Brief communication
Lymphangioleiomyomatosis (LAM) Cell Atlas

Yina Du, Minzhe Guo, Yixin Wu, Andrew Wagner, Anne Karina Perl, Kathryn Wikenheiser-Brokamp, Jane Yu, Nishant Gupta, Elizabeth Kopras, Vera Krymskaya, Kseniya Obraztsova, Yan Tang, David Kwiatkowski, Elizabeth P Henske, Francis McCormack, Yan Xu

doi: 10.1136/thoraxjnl-2022-218772

September 05, 2022

Critical care
Population study on diagnosis, treatment and outcomes of critically ill patients with tuberculosis (2008–2018)

Christina So, Lowell Ling, Wai Tat Wong, Jack Zhenhe Zhang, Chun Ming Ho, Pauline Yeung Ng, Hoi Ping Shum, Alwin Wai Tak Yeung, Kai Cheuk Sin, Jacky Chan, Ka Fai Au, Ting Liong, Eunise Ho, Fu Loi Chow, Laptin Ho, Kai Man Chan, Gavin Matthew Joynt

doi: 10.1136/thorax-2022-218868

September 02, 2022

Non-invasive ventilation
Cost-effectiveness of outpatient versus inpatient non-invasive ventilation setup in obesity hypoventilation syndrome: the OPIP trial

Patrick Brian Murphy, Maxime Patout, Gill Arbane, Swapna Mandal, Georgios Kaltsakas, Michael I Polkey, Mark Elliott, Jean-François Muir, Abdel Douiri, David Parkin, Jean-Paul Janssens, Jean Louis Pépin, Antoine Cuvelier, Clare Flach, Nicholas Hart

doi: 10.1136/thorax-2021-218497

September 01, 2022

Editorial
Immunotherapy in non-small-cell lung cancer: new data support its use, but some challenges remain

Allan Ramos-Esquivel

doi: 10.1136/thorax-2022-219472
Brief communication
Quality of life in patients with slowly progressive neuromuscular disorders dependent on mechanical ventilation

Mathieu Delorme, Christian Reveillere, Christian Devaux, Sandrine Segovia-Kueny, Frédéric Lofaso, Ghilas Boussaid

doi: 10.1136/thorax-2022-219211
Editorial
Chronic neonatal lung disease: time to look beyond the alveolus

André Gie, Jaan Toelen

doi: 10.1136/thorax-2022-219482

August 22, 2022

Brief communication
Lung cancer screening provides an opportunity for early diagnosis and treatment of interstitial lung disease

Richard J Hewitt, Emily C Bartlett, Rea Ganatra, Haroun Butt, Vasilis Kouranos, Felix Chua, Maria Kokosi, Philip L Molyneaux, Sujal R Desai, Athol U Wells, R Gisli Jenkins, Elisabetta A Renzoni, Samuel V Kemp, Anand Devaraj, Peter M George

doi: 10.1136/thorax-2022-219068

August 19, 2022

Editorial
From bronchiolitis endotyping to asthma risk assessment

Silvia Carraro, Valentina Agnese Ferraro, Stefania Zanconato

doi: 10.1136/thorax-2022-219388

August 15, 2022

Respiratory research
Optimising breathlessness triggered services for older people with advanced diseases: a multicentre economic study (OPTBreathe)

Deokhee Yi, Charles C Reilly, Gao Wei, Irene J Higginson on behalf of OPTBreathe collaborators

doi: 10.1136/thoraxjnl-2021-218251

August 10, 2022

Chronic obstructive pulmonary disease
Oscillatory positive expiratory pressure therapy in COPD (O-COPD): a randomised controlled trial

Saeed M Alghamdi, Abdullah S Alsulayyim, Ali M Alasmari, Keir E J Philip, Sara C Buttery, Winston A S Banya, Michael I Polkey, Surinder S Birring, Nicholas S Hopkinson

doi: 10.1136/thorax-2022-219077
Respiratory research
Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis

Yue Su, Johnatas Dutra Silva, Declan Doherty, David A Simpson, Daniel J Weiss, Sara Rolandsson-Enes, Daniel F McAuley, Cecilia M O'Kane, Derek P Brazil, Anna D Krasnodembskaya

doi: 10.1136/thoraxjnl-2021-218194

August 05, 2022

Interstitial lung disease
MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study

John S Kim, Ani W Manichaikul, Eric A Hoffman, Pallavi Balte, Michaela R Anderson, Elana J Bernstein, Purnema Madahar, Elizabeth C Oelsner, Steven M Kawut, Artur Wysoczanski, Andrew F Laine, Ayodeji Adegunsoye, Jennie Z Ma, Margaret A Taub, Rasika A Mathias, Stephen S Rich, Jerome I Rotter, Imre Noth, Christine Kim Garcia, R Graham Barr, Anna J Podolanczuk

doi: 10.1136/thorax-2021-218139

July 30, 2022

Asthma
Preterm or early term birth and long-term risk of asthma into midadulthood: a national cohort and cosibling study

Casey Crump, Jan Sundquist, Kristina Sundquist

doi: 10.1136/thorax-2022-218931
Asthma
Nasopharyngeal lipidomic endotypes of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study

Michimasa Fujiogi, Zhaozhong Zhu, Yoshihiko Raita, Tadao Ooka, Juan C Celedon, Robert Freishtat, Carlos A Camargo, Kohei Hasegawa

doi: 10.1136/thorax-2022-219016
Case based discussion
Young woman with multiple lung nodules: a pulmonary oxymoron

Hiromu Tanaka, Hiroki Kabata, Katsura Emoto, Shigenori Hayashi, Kyohei Masai, Koichi Fukunaga

doi: 10.1136/thorax-2022-218720

July 27, 2022

Respiratory epidemiology
Patient outcomes following emergency admission to hospital for COVID-19 compared with influenza: retrospective cohort study

Thomas Woodcock, Geva Greenfield, Ajit Lalvani, Azeem Majeed, Paul Aylin

doi: 10.1136/thoraxjnl-2021-217858

July 22, 2022

State of the art review
Building a home ventilation programme: population, equipment, delivery and cost

Michel Toussaint, Peter J Wijkstra, Doug McKim, Joshua Benditt, Joao Carlos Winck, Jacek Nasiłowski, Jean-Christian Borel

doi: 10.1136/thoraxjnl-2021-218410

July 20, 2022

Smoking
Assessment of formal tobacco treatment and smoking cessation in dual users of cigarettes and e-cigarettes

Brendan T Heiden, Timothy B Baker, Nina Smock, Giang Pham, Jingling Chen, Laura J Bierut, Li-Shiun Chen

doi: 10.1136/thorax-2022-218680

July 18, 2022

Asthma
Single dose of budesonide/formoterol turbuhaler compared to salbutamol pMDI for speed of bronchodilator onset in asthma: a randomised cross-over trial

Nethmi Kearns, Mathew Williams, Pepa Bruce, Melissa Black, Ciléin Kearns, Jenny Sparks, Irene Braithwaite, Mark Weatherall, Richard Beasley

doi: 10.1136/thorax-2022-219052

July 16, 2022

Interstitial lung disease
The relationship between interstitial lung abnormalities, mortality, and multimorbidity: a cohort study

Jason Leigh Sanders, Gisli Axelsson, Rachel Putman, Aravind Menon, Josée Dupuis, Hanfei Xu, Shuai Wang, Joanne Murabito, Ramachandran Vasan, Tetsuro Araki, Mizuki Nishino, George R Washko, Hiroto Hatabu, George O'Connor, Gunnar Gudmundsson, Vilmundur Gudnason, Gary M Hunninghake

doi: 10.1136/thoraxjnl-2021-218315

July 14, 2022

Lung cancer
Effects of enhanced recovery after surgery plus pulmonary rehabilitation on complications after video-assisted lung cancer surgery: a multicentre randomised controlled trial

Yu Zheng, Mao Mao, Fang Li, Lu Wang, Xintong Zhang, Xiu Zhang, Haiming Wang, Huiqing Zhou, Meifang Ji, Yulong Wang, Liang Liu, Quan Zhu, Jan D Reinhardt, Xiao Lu

doi: 10.1136/thoraxjnl-2021-218183

July 08, 2022

State of the art review
Pleural and transpulmonary pressures to tailor protective ventilation in children

Meryl Vedrenne-Cloquet, Sonia Khirani, Robinder Khemani, Fabrice Lesage, Mehdi Oualha, Sylvain Renolleau, Davide Chiumello, Alexandre Demoule, Brigitte Fauroux

doi: 10.1136/thorax-2021-218538

July 06, 2022

Respiratory infection
C reactive protein utilisation, a biomarker for early COVID-19 treatment, improves lenzilumab efficacy: results from the randomised phase 3 ‘LIVE-AIR’ trial

Zelalem Temesgen, Colleen F Kelley, Frank Cerasoli, Adrian Kilcoyne, Dale Chappell, Cameron Durrant, Omar Ahmed, Gabrielle Chappell, Victoria Catterson, Christopher Polk, Andrew Badley, Vincent C Marconi LIVE-AIR Study Group

doi: 10.1136/thoraxjnl-2022-218744

June 29, 2022

Chronic obstructive pulmonary disease
Subtyping emphysematous COPD by respiratory volume change distributions on CT

Hiroshi Shima, Naoya Tanabe, Akira Oguma, Kaoruko Shimizu, Shizuo Kaji, Kunihiko Terada, Tsuyoshi Oguma, Takeshi Kubo, Masaru Suzuki, Hironi Makita, Atsuyasu Sato, Masaharu Nishimura, Susumu Sato, Satoshi Konno, Toyohiro Hirai

doi: 10.1136/thoraxjnl-2021-218288

June 23, 2022

Images in Thorax
Osteoblastic flare phenomenon in a patient treated for disseminated non-tuberculous mycobacterial infection

Ruei-Lin Sun, Sheng-Wei Pan, Jia-Yih Feng, Chun-Yu Liu, Yuh-Min Chen

doi: 10.1136/thoraxjnl-2021-218351

June 16, 2022

Images in Thorax
’Pulmonary tuberculosis presenting as massive spontaneous pneumomediastinum and subcutaneous emphysema’
Free

Avinash Anil Nair, Leena RV, Devasahayam Jesudas Christopher

doi: 10.1136/thoraxjnl-2022-218908
Asthma
Environmental risks and sphingolipid signatures in adult asthma and its phenotypic clusters: a multicentre study

Chao-Chien Wu, Chin-Chou Wang, Wen-Yu Chung, Chau-Chyun Sheu, Yi-Hsin Yang, Ming-Yen Cheng, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin, Yu-Feng Wei, Ching-Hsiung Lin, Sheng-Hao Lin, Jeng-Yuan Hsu, Wei-Chang Huang, Chia-Cheng Tseng, Yung-Fa Lai, Meng-Hsuan Cheng, Huang-Chi Chen, Chih-Jen Yang, Shih-Chang Hsu, Chian-Heng Su, Chien-Jen Wang, Huei-Ju Liu, Hua-Ling Chen, Yuan-Ting Hsu, Chih-Hsing Hung, Chon-Lin Lee, Ming-Shyan Huang, Shau-Ku Huang

doi: 10.1136/thoraxjnl-2021-218396
Respiratory research
Disease monitoring using lung function trajectory in lymphangioleiomyomatosis: assessment in two national cohorts

Jan Johnson, Iain Stewart, Simon R Johnson

doi: 10.1136/thoraxjnl-2021-217809

June 10, 2022

Lung cancer
Impact of PD1 and PDL1 immunotherapy on non-small cell lung cancer outcomes: a systematic review

Shivani Setur Kanabar, Abhinav Tiwari, Vina Soran, Prashanthan Balendran, Malcolm Price, Alice Margaret Turner

doi: 10.1136/thoraxjnl-2020-215614
Interstitial lung disease
Impact of interstitial lung abnormalities on postoperative pulmonary complications and survival of lung cancer

Yunjoo Im, Man Pyo Chung, Kyung Soo Lee, Joungho Han, Myung Jin Chung, Hong Kwan Kim, Jong Ho Cho, Yong Soo Choi, Sujin Park, Ho Joong Kim, O Jung Kwon, Boram Park, Hongseok Yoo

doi: 10.1136/thoraxjnl-2021-218055
Respiratory infection
Ultra-low-dose CT versus chest X-ray for patients suspected of pulmonary disease at the emergency department: a multicentre randomised clinical trial

Inge A H van den Berk, Maadrika M N P Kanglie, Tjitske S R van Engelen, Josje Altenburg, Jouke T Annema, Ludo F M Beenen, Bart Boerrigter, Marije K Bomers, Paul Bresser, Elvin Eryigit, Maarten Groenink, Suzanne M R Hochheimer, Frits Holleman, Jos A J Kooter, Ramon B van Loon, Mitran Keijzers, Ivo van der Lee, Paul Luijendijk, Lilian J Meijboom, Saskia Middeldorp, Laura J Schijf, Robin Soetekouw, Ralf W Sprengers, Alexander D Montauban van Swijndregt, Wouter de Monyé, Milan L Ridderikhof, Michiel M Winter, Shandra Bipat, Marcel G W Dijkgraaf, Patrick M M Bossuyt, Jan M Prins, Jaap Stoker on behalf of the OPTIMACT study group

doi: 10.1136/thoraxjnl-2021-218337

May 29, 2022

Interstitial lung disease
Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

Luke M Kraven, Adam R Taylor, Philip L Molyneaux, Toby M Maher, John E McDonough, Marco Mura, Ivana V Yang, David A Schwartz, Yong Huang, Imre Noth, Shwu Fan Ma, Astrid J Yeo, William A Fahy, R Gisli Jenkins, Louise V Wain

doi: 10.1136/thoraxjnl-2021-218563

May 25, 2022

Critical care
Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39

Shilpa Tiwari-Heckler, Ghee Rye Lee, James Harbison, Carola Ledderose, Eva Csizmadia, David Melton, Quanzhi Zhang, Wolfgang Junger, Guanqing Chen, Carl J Hauser, Leo E Otterbein, Maria Serena Longhi, Simon Christopher Robson

doi: 10.1136/thoraxjnl-2021-218047

May 17, 2022

Critical care
High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial
Free

Claudia Crimi, Alberto Noto, Fabiana Madotto, Mariachiara Ippolito, Santi Nolasco, Raffaele Campisi, Stefano De Vuono, Giuseppe Fiorentino, Ioannis Pantazopoulos, Athanasios Chalkias, Alessandro Libra, Alessio Mattei, Raffaele Scala, Enrico M Clini, Begum Ergan, Manel Lujan, Joao Carlos Winck, Antonino Giarratano, Annalisa Carlucci, Cesare Gregoretti, Paolo Groff, Andrea Cortegiani on behalf of the COVID-HIGH Investigators

doi: 10.1136/thoraxjnl-2022-218806
Respiratory research
Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant

Motaharehsadat Heydarian, Prajakta Oak, Xin Zhang, Nona Kamgari, Alida Kindt, Markus Koschlig, Tina Pritzke, Erika Gonzalez-Rodriguez, Kai Förster, Rory E Morty, Friederike Häfner, Christoph Hübener, Andreas W Flemmer, Ali Oender Yildirim, Deepti Sudheendra, Xuefei Tian, Agnese Petrera, Holger Kirsten, Peter Ahnert, Nick Morrell, Tushar J Desai, Jennifer Sucre, Edda Spiekerkoetter, Anne Hilgendorff

doi: 10.1136/thoraxjnl-2021-218083

May 10, 2022

Respiratory epidemiology
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease

Anna Guyatt, Catherine John, Alexander T Williams, Nick Shrine, Nicola F Reeve, SpiroMeta consortium, Ian Sayers, Ian Hall, Louise V Wain, Nuala Sheehan, Frank Dudbridge, Martin D Tobin

doi: 10.1136/thoraxjnl-2021-217993

May 02, 2022

Asthma
Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma

Alberta L Wang, Lies Lahousse, Amber Dahlin, Ahmed Edris, Michael McGeachie, Sharon M Lutz, Joanne E Sordillo, Guy Brusselle, Jessica Lasky-Su, Scott T Weiss, Carlos Iribarren, Meng X Lu, Kelan G Tantisira, Ann C Wu

doi: 10.1136/thoraxjnl-2021-217674

April 28, 2022

Respiratory research
Effects of traditional mind–body movement therapy on chronic cardiopulmonary dyspnoea: a systematic review and meta-analysis

Tiange Zhang, Rui Zhou, Ting Wang, Yijun Xin, Xiaohong Liu, Huiting Huang

doi: 10.1136/thoraxjnl-2021-218030

April 27, 2022

Asthma
Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS

Subhabrata Moitra, Anne-Elie Carsin, Michael J Abramson, Simone Accordini, Andre F S Amaral, Josep Anto, Roberto Bono, Lidia Casas Ruiz, Isa Cerveri, Leda Chatzi, Pascal Demoly, Sandra Dorado-Arenas, Bertil Forsberg, Frank Gilliland, Thorarinn Gislason, Jose A Gullón, Joachim Heinrich, Mathias Holm, Christer Janson, Rain Jogi, Francisco Gómez Real, Debbie Jarvis, Bénédicte Leynaert, Dennis Nowak, Nicole Probst-Hensch, José Luis Sánchez-Ramos, Chantal Raherison-Semjen, Valerie Siroux, Stefano Guerra, Manolis Kogevinas, Judith Garcia-Aymerich

doi: 10.1136/thoraxjnl-2021-217867

April 26, 2022

Respiratory infection
High prevalence of multiple serotypes of pneumococci in patients with pneumonia and their associated risk factors

Bhim Gopal Dhoubhadel, Motoi Suzuki, Tomoko Ishifuji, Makito Yaegashi, Norichika Asoh, Masayuki Ishida, Sugihiro Hamaguchi, Masahiro Aoshima, Michio Yasunami, Koya Ariyoshi, Konosuke Morimoto Adult Pneumonia Study Group-Japan (APSG-J)

doi: 10.1136/thoraxjnl-2021-217979

April 25, 2022

Cystic fibrosis
Longitudinal lung clearance index and association with structural lung damage in children with cystic fibrosis

Marcus Svedberg, Henrik Imberg, Per Magnus Gustafsson, Harm Tiddens, Gwyneth Davies, Anders Lindblad

doi: 10.1136/thoraxjnl-2021-218178

April 22, 2022

Paediatric lung disease
Bronchopulmonary dysplasia and expiratory airflow at 8 years in children born extremely preterm in the post-surfactant era

Lex William Doyle, Sarath Ranganathan, Jeanie Cheong The Victorian Infant Collaborative Study Group

doi: 10.1136/thoraxjnl-2022-218792

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