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Online First

April 19, 2021

Brief communication
Association of heated tobacco product use with tobacco use cessation in a Japanese workplace: a prospective study
Free

Makiko Kanai, Osamu Kanai, Takahiro Tabuchi, Tadashi Mio

doi: 10.1136/thoraxjnl-2020-216253
Brief communication
Impact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: the SUR-VAPES Chronic Study
Free

Lorenzo Loffredo, Roberto Carnevale, Simona Battaglia, Roberta Marti, Stefano Pizzolo, Simona Bartimoccia, Cristina Nocella, Vittoria Cammisotto, Sebastiano Sciarretta, Isotta Chimenti, Elena De Falco, Elena Cavarretta, Mariangela Peruzzi, Antonino Marullo, Fabio Miraldi, Francesco Violi, Andrea Morelli, Giuseppe Biondi-Zoccai, Giacomo Frati

doi: 10.1136/thoraxjnl-2020-215900
Commentary
Cooling off the heated controversy of a safer cigarette: heat-not-burn no better than traditional combustion cigarettes
Free

Irina Petrache, Esther de Boer

doi: 10.1136/thoraxjnl-2020-216743

April 16, 2021

Critical care
Attributable mortality of acute respiratory distress syndrome: a systematic review, meta-analysis and survival analysis using targeted minimum loss-based estimation

Lisa K Torres, Katherine L Hoffman, Clara Oromendia, Ivan Diaz, John S Harrington, Edward J Schenck, David R Price, Luis Gomez-Escobar, Angelica Higuera, Mayra Pinilla Vera, Rebecca M Baron, Laura E Fredenburgh, Jin-Won Huh, Augustine M K Choi, Ilias I Siempos

doi: 10.1136/thoraxjnl-2020-215950
Editorial
Can clinical benefits of modulators effectively ‘modulate’ adherence in people with CF?

Chelsea S Davis, Jonathan D Cogen

doi: 10.1136/thoraxjnl-2021-216974
Sleep
Pulse arrival time, a novel sleep cardiovascular marker: the multi-ethnic study of atherosclerosis

Younghoon Kwon, Christopher Wiles, B Eugene Parker, Brian R Clark, Min-Woong Sohn, Sara Mariani, Jin-Oh Hahn, David R Jacobs, James H Stein, Joao Lima, Vishesh Kapur, Andrew Wellman, Susan Redline, Ali Azarbarzin

doi: 10.1136/thoraxjnl-2020-216399

April 15, 2021

Critical care
Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis

Leanne M Aitken, Kalliopi Kydonaki, Bronagh Blackwood, Laurence G Trahair, Edward Purssell, Mandeep Sekhon, Timothy S Walsh

doi: 10.1136/thoraxjnl-2020-216098
Interstitial lung disease
Fibrotic extracellular matrix induces release of extracellular vesicles with pro-fibrotic miRNA from fibrocytes

Seidai Sato, Sy Giin Chong, Chandak Upagupta, Toyoshi Yanagihara, Takuya Saito, Chiko Shimbori, Pierre-Simon Bellaye, Yasuhiko Nishioka, Martin RJ Kolb

doi: 10.1136/thoraxjnl-2020-215962
Brief communication
Inhaled nitric oxide improves the hepatopulmonary syndrome: a physiologic analysis

Samir Gupta, Rosalind Tang, Abdul Al-Hesayen

doi: 10.1136/thoraxjnl-2020-216128
Brief communication
Genetic polymorphism in ATIC is associated with effectiveness and toxicity of pemetrexed in non-small-cell lung cancer

Sabine Visser, Stijn Koolen, Nadine van Donk, Nico van Walree, Cor van der Leest, Robin Cornelissen, Ron van Schaik, Ron Mathijssen, Joachim Aerts, Bruno H Stricker

doi: 10.1136/thoraxjnl-2020-216504
Controversies and challenges in respiratory medicine
Functional respiratory assessment: some key misconceptions and their clinical implications

José Alberto Neder

doi: 10.1136/thoraxjnl-2020-215287
Brief communication
Rectal organoid morphology analysis (ROMA) as a promising diagnostic tool in cystic fibrosis

Senne Cuyx, Anabela Santo Ramalho, Nikky Corthout, Steffen Fieuws, Eva Fürstová, Kaline Arnauts, Marc Ferrante, Catherine Verfaillie, Sebastian Munck, Mieke Boon, Marijke Proesmans, Lieven Dupont, Kris De Boeck, François Vermeulen On behalf of the Belgian Organoid Project

doi: 10.1136/thoraxjnl-2020-216368
Lung cancer
Lung cancer probability and clinical outcomes of baseline and new subsolid nodules detected on low-dose CT screening

Yeon Wook Kim, Byoung Soo Kwon, Sung Yoon Lim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Kyung Won Lee, Jae Ho Lee, Jin-Haeng Chung, Eunjeong Ji, Choon-Taek Lee

doi: 10.1136/thoraxjnl-2020-215107
Brief communication
Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

H Laura Aaltonen, Madeleine Petersson Sjögren, Jonas K F Jakobsson, Hanna Nicklasson, Sandra Diaz, Francisco Sánchez Montiel, Sophia Zackrisson, Veronica Ideböhn, Gunnar Engström, Jakob Löndahl, Per Wollmer

doi: 10.1136/thoraxjnl-2020-214523
Non-invasive ventilation
Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis

Marius Lebret, Antoine Léotard, Jean Louis Pépin, Wolfram Windisch, Emelie Ekkernkamp, Mercedes Pallero, M-Ángeles Sánchez-Quiroga, Nicholas Hart, Julia L Kelly, Maxime Patout, Georg Chistian Funk, Marieke L Duiverman, Juan F Masa, Anita Simonds, Patrick Brian Murphy, Peter J Wijkstra, Michael Dreher, Jan Storre, Charles Khouri, Jean-Christian Borel

doi: 10.1136/thoraxjnl-2020-215613

April 12, 2021

Respiratory infection
Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19

Anno Saris, Tom DY Reijnders, Esther J Nossent, Alex R Schuurman, Jan Verhoeff, Saskia van Asten, Hetty Bontkes, Siebe Blok, Janwillem Duitman, Harm-Jan Bogaard, Leo Heunks, Rene Lutter, Tom van der Poll, Juan J Garcia Vallejo ArtDECO consortium and the Amsterdam UMC COVID study group

doi: 10.1136/thoraxjnl-2020-216256

April 09, 2021

Controversies and challenges in respiratory medicine
COVID-19 and ethnicity:has history repeated itself?
Free

Annastazia E Learoyd, Abdel Douiri, Nicholas Hart

doi: 10.1136/thoraxjnl-2021-216992
Editorial
Improved asthma control during the COVID-19 pandemic: are there lessons to be learnt?
Free

Imogen P Skene, Paul E Pfeffer

doi: 10.1136/thoraxjnl-2021-216930

April 07, 2021

Editorial
Bedside assessment of pulmonary gas exchange in very preterm infants: a pathophysiological approach to bronchopulmonary dysplasia diagnosis?

T'ng Chang Kwok, Don Sharkey

doi: 10.1136/thoraxjnl-2021-216912
Chronic obstructive pulmonary disease
Small airway determinants of airflow limitation in chronic obstructive pulmonary disease

Vasiliy V Polosukhin, Sergey S Gutor, Rui-Hong Du, Bradley W Richmond, Pierre P Massion, Pingsheng Wu, Justin M Cates, Kim L Sandler, Stephen I Rennard, Timothy S Blackwell

doi: 10.1136/thoraxjnl-2020-216037

March 31, 2021

Editorial
Changing priorities for pulmonary fibrosis: the patient will see you now!

Laura Fabbri, Steve Jones

doi: 10.1136/thoraxjnl-2020-216616
Editorial
Short sleep, sleep apnoea-associated hypoxaemic burden and kidney function: more questions than answers

Julie M Neborak, Babak Mokhlesi

doi: 10.1136/thoraxjnl-2020-216618

March 30, 2021

Respiratory epidemiology
Epidemiology and prognostic factors of pleural empyema

Antonio Bobbio, Samir Bouam, Jerome Frenkiel, Kevin Zarca, Ludovic Fournel, Emelyne Canny, Philippe Icard, Raphaël Porcher, Marco Alifano

doi: 10.1136/thoraxjnl-2020-215267

March 29, 2021

Asthma
Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data

Syed A Shah, Jennifer K Quint, Bright I Nwaru, Aziz Sheikh

doi: 10.1136/thoraxjnl-2020-216512
Brief communication
Decrease in hospital admissions for respiratory diseases during the COVID-19 pandemic: a nationwide claims study
Free

Kyungmin Huh, Young-Eun Kim, Wonjun Ji, Dong Wook Kim, Eun-Joo Lee, Jong-Hun Kim, Ji-Man Kang, Jaehun Jung

doi: 10.1136/thoraxjnl-2020-216526
Asthma
Impact of COVID-19 lockdown on emergency asthma admissions and deaths: national interrupted time series analyses for Scotland and Wales
Free

Gwyneth A Davies, Mohammad A Alsallakh, Shanya Sivakumaran, Eleftheria Vasileiou, Ronan A Lyons, Chris Robertson, Aziz Sheikh EAVE II Collaborators

doi: 10.1136/thoraxjnl-2020-216380

March 25, 2021

Cystic fibrosis
Longitudinal effects of ivacaftor and medicine possession ratio in people with the Gly551Asp mutation: a 5-year study

Ruth Marian Mitchell, Andrew M Jones, Katie Stocking, Philip Foden, Peter J Barry

doi: 10.1136/thoraxjnl-2020-215556
Critical care
Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis
Free

Boun Kim Tan, Sabine Mainbourg, Arnaud Friggeri, Laurent Bertoletti, Marion Douplat, Yesim Dargaud, Claire Grange, Hervé Lobbes, Steeve Provencher, Jean-Christophe Lega

doi: 10.1136/thoraxjnl-2020-215383
Brief communication
Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study

Andrew J Swift, Frederick Wilson, Marcella Cogliano, Lindsay Kendall, Faisal Alandejani, Samer Alabed, Paul Hughes, Yousef Shahin, Laura Saunders, Charlotte Oram, David Capener, Alex Rothman, Pankaj Garg, Christopher Johns, Matthew Austin, Alistair Macdonald, Jo Pickworth, Peter Hickey, Robin Condliffe, Anthony Cahn, Allan Lawrie, Jim M Wild, David G Kiely

doi: 10.1136/thoraxjnl-2020-216078
Asthma
Adverse childhood experiences and asthma: trajectories in a national cohort

Kathrine Pape, Whitney Cowell, Camilla Sandal Sejbaek, Niklas Worm Andersson, Cecilie Svanes, Henrik Albert Kolstad, Xiaoqin Liu, Karin Sørig Hougaard, Rosalind J Wright, Vivi Schlünssen

doi: 10.1136/thoraxjnl-2020-214528

March 23, 2021

Asthma
Temperature variability and asthma hospitalisation in Brazil, 2000–2015: a nationwide case-crossover study

Yao Wu, Rongbin Xu, Bo Wen, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo H Saldiva, Shanshan Li, Yuming Guo

doi: 10.1136/thoraxjnl-2020-216549
Brief communication
Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study

Belén Pérez-Mies, María Gómez-Rojo, Irene Carretero-Barrio, Tommaso Bardi, Amparo Benito, Mónica García-Cosío, Álvaro Caballero, Raul de Pablo, Juan Carlos Galán, David Pestaña, Jose Palacios

doi: 10.1136/thoraxjnl-2020-216714
Pulmonary vasculature
Non-invasive early exclusion of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: the InShape II study

Gudula J A M Boon, Yvonne M Ende-Verhaar, Roisin Bavalia, Lahassan H El Bouazzaoui, Marion Delcroix, Olga Dzikowska-Diduch, Menno V Huisman, Katarzyna Kurnicka, Albert T A Mairuhu, Saskia Middeldorp, Piotr Pruszczyk, Dieuwertje Ruigrok, Peter Verhamme, Hubert W Vliegen, Anton Vonk Noordegraaf, Joris W J Vriend, Frederikus A Klok InShape II study group

doi: 10.1136/thoraxjnl-2020-216324
Editorial
Air pollution and chronic bronchitis: the evidence firms up

Frank Kelly

doi: 10.1136/thoraxjnl-2021-216883

March 15, 2021

Lung cancer
Pleural recurrence after transthoracic needle lung biopsy in stage I lung cancer: a systematic review and individual patient-level meta-analysis

Hyunsook Hong, Seokyung Hahn, Haruhisa Matsuguma, Masayoshi Inoue, Yasushi Shintani, Osamu Honda, Yotaro Izumi, Keisuke Asakura, Hisao Asamura, Tetsuya Isaka, Kyungjong Lee, Yong Soo Choi, Young Tae Kim, Chang Min Park, Jin Mo Goo, Soon Ho Yoon

doi: 10.1136/thoraxjnl-2020-216492
Respiratory infection
Empiric antibiotics for community-acquired pneumonia in adult patients: a systematic review and a network meta-analysis

Lara Montes-Andujar, Elena Tinoco, Orville Baez-Pravia, Carlos Martin-Saborido, Pablo Blanco-Schweizer, Carmen Segura, Estefania Prol Silva, Vivivan Reyes, Ana Rodriguez Cobo, Carmen Zurdo, Verónica Angel, Olga Varona, José Valero, Rafael Suarez del Villar, Guillermo Ortiz, Julio Villanueva, Justo Menéndez, Jesús Blanco, Antoni Torres, Pablo A Cardinal-Fernández

doi: 10.1136/thoraxjnl-2019-214054

March 12, 2021

Critical care
Five-year outcome of respiratory muscle weakness at intensive care unit discharge: secondary analysis of a prospective cohort study

Nathalie Van Aerde, Philippe Meersseman, Yves Debaveye, Alexander Wilmer, Jan Gunst, Michael P Casaer, Joost Wauters, Pieter J Wouters, Rik Gosselink, Greet Van den Berghe, Greet Hermans

doi: 10.1136/thoraxjnl-2020-216720
State of the art review
Role of extracellular vesicles in chronic lung disease

Anne Trappe, Seamas C Donnelly, Paul McNally, Judith A Coppinger

doi: 10.1136/thoraxjnl-2020-216370

March 11, 2021

Environmental exposure
Effect of exposure to fine particulate matter during pregnancy and infancy on paediatric allergic rhinitis

Yu-Ting Lin, Hao Shih, Chau-Ren Jung, Chi-Min Wang, Ya-Chu Chang, Chia-Yun Hsieh, Bing-Fang Hwang

doi: 10.1136/thoraxjnl-2020-215025

March 10, 2021

Respiratory infection
Early prognostication of COVID-19 to guide hospitalisation versus outpatient monitoring using a point-of-test risk prediction score
Free

Felix Chua, Rama Vancheeswaran, Adrian Draper, Tejal Vaghela, Matthew Knight, Rahul Mogal, Jaswinder Singh, Lisa G Spencer, Erica Thwaite, Harry Mitchell, Sam Calmonson, Noor Mahdi, Shershah Assadullah, Matthew Leung, Aisling O'Neill, Chhaya Popat, Radhika Kumar, Thomas Humphries, Rebecca Talbutt, Sarika Raghunath, Philip L Molyneaux, Miriam Schechter, Jeremy Lowe, Andrew Barlow

doi: 10.1136/thoraxjnl-2020-216425
State of the art review
Use of preclinical models for malignant pleural mesothelioma

Marie Shamseddin, Joanna Obacz, Mathew J Garnett, Robert Campbell Rintoul, Hayley Elizabeth Francies, Stefan John Marciniak

doi: 10.1136/thoraxjnl-2020-216602

March 08, 2021

Brief communication
Psychological impact of genetic and clinical screening for pulmonary fibrosis on asymptomatic first-degree relatives of affected individuals

Nikkola Carmichael, Jose M Martinez Manzano, Luisa D Quesada-Arias, Sergio de Frías Poli, Maura Alvarez Baumgartner, Maria A Planchart Ferretto, Lisa DiGianni, Shannon Gampala-Sagar, Dominick A Leone, Swati Gulati, Souheil Y El-Chemaly, Hilary J Goldberg, Rachel Putman, Hiroto Hatabu, Ivan O Rosas, Gary M Hunninghake, Benjamin A Raby

doi: 10.1136/thoraxjnl-2020-216244
Rehabilitation
Efficacy of unsupervised exercise in adults with obstructive lung disease: a systematic review and meta-analysis

Daniel Taylor, Alex R Jenkins, Kate Parrott, Alex Benham, Samantha Targett, Arwel W Jones

doi: 10.1136/thoraxjnl-2020-216007

March 02, 2021

Brief communication
COPD discharge bundle and pulmonary rehabilitation referral and uptake following hospitalisation for acute exacerbation of COPD

Ruth E Barker, Samantha SC Kon, Stuart F Clarke, Jenni Wenneberg, Claire M Nolan, Suhani Patel, Jessica A Walsh, Oliver Polgar, Matthew Maddocks, Morag Farquhar, Nicholas S Hopkinson, Derek Bell, Jadwiga A Wedzicha, William D-C. Man

doi: 10.1136/thoraxjnl-2020-215464
Brief communication
The Severe Respiratory Insufficiency Application (SRI App): a pilot randomised controlled trial

Daniel Sebastian Majorski, Sarah Bettina Schwarz, Friederike Sophie Magnet, Rebar Ahmad, Tim Mathes, Wolfram Windisch

doi: 10.1136/thoraxjnl-2020-216319
Editorial
Citizen science in the time of COVID-19
Free

Linda J Birkin, Eleftheria Vasileiou, Helen Ruth Stagg

doi: 10.1136/thoraxjnl-2020-216673
Occupational lung disease
Airborne occupational exposures and the risk of developing respiratory symptoms and airway obstruction in the Lifelines Cohort Study

Md Omar Faruque, H Marike Boezen, Hans Kromhout, Roel Vermeulen, Ute Bültmann, Judith M Vonk

doi: 10.1136/thoraxjnl-2020-216721

February 25, 2021

Brief communication
Bronchiectasis severity correlates with outcome in patients with primary antibody deficiency

Jimstan Periselneris, Silke Schelenz, Michael Loebinger, Patricia Macedo, Zoe Adhya, Darius Armstrong-James, W Peter Kelleher

doi: 10.1136/thoraxjnl-2020-215585
Environmental exposure
Greenness may improve lung health in low–moderate but not high air pollution areas: Seven Northeastern Cities’ study

Yang Zhou, Dinh S Bui, Jennifer L Perret, Adrian J Lowe, Caroline J Lodge, Iana Markevych, Joachim Heinrich, Michael S Bloom, Luke D Knibbs, Bin Jalaludin, Bo-Yi Yang, Hong-Yao Yu, Xiao-Wen Zeng, Yunjiang Yu, Shyamali C Dharmage, Guang-Hui Dong

doi: 10.1136/thoraxjnl-2020-214767
Paediatric lung disease
Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts

Patricia de Gouveia Belinelo, Adam M Collison, Vanessa E Murphy, Paul D Robinson, Kathryn Jesson, Kate Hardaker, Ediane de Queiroz Andrade, Christopher Oldmeadow, Gabriela Martins Costa Gomes, Peter D Sly, Jakob Usemann, Rhea Appenzeller, Olga Gorlanova, Oliver Fuchs, Philipp Latzin, Peter G Gibson, Urs Frey, Joerg Mattes

doi: 10.1136/thoraxjnl-2020-215526

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April 19, 2021

April 16, 2021

April 15, 2021

April 12, 2021

April 09, 2021

April 07, 2021

March 31, 2021

March 30, 2021

March 29, 2021

March 25, 2021

March 23, 2021

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