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Online First

December 01, 2022

Lung cancer
Airflow limitation and mortality during cancer screening in the National Lung Screening Trial: why quantifying airflow limitation matters

Robert P Young, Ralph C Ward, Raewyn J Scott, Greg D Gamble, Gerard Silvestri

doi: 10.1136/thorax-2022-219334
Editorial
Artificial intelligence in differentiating malignant from benign pleural effusion: a step beyond conventional methods

Younhyun Jung, Eun Young Kim

doi: 10.1136/thorax-2022-219608

November 25, 2022

Brief communication
Growing small solid nodules in lung cancer screening: safety and efficacy of a 200 mm³ minimum size threshold for multidisciplinary team referral

Andrew W Creamer, Carolyn Horst, Jennifer L Dickson, Sophie Tisi, Helen Hall, Priyam Verghese, Ruth Prendecki, Amyn Bhamani, John McCabe, Kylie Gyertson, Anne-Marie Mullin, Jonathan Teague, Laura Farrelly, Allan Hackshaw, Arjun Nair, SUMMIT consortium, Anand Devaraj, Sam M Janes

doi: 10.1136/thorax-2022-219403

November 24, 2022

Respiratory epidemiology
Mortality in non-exacerbating COPD: a longitudinal analysis of UK primary care data

Alexandra Lenoir, Hannah Whittaker, Alicia Gayle, Debbie Jarvis, Jennifer K Quint

doi: 10.1136/thorax-2022-218724

November 23, 2022

Asthma
Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)
Free

Florence Tydeman, Paul E Pfeffer, Giulia Vivaldi, Hayley Holt, Mohammad Talaei, David Jolliffe, Gwyneth Davies, Ronan A Lyons, Christopher Griffiths, Frank Kee, Aziz Sheikh, Seif O Shaheen, Adrian R Martineau

doi: 10.1136/thorax-2022-219591

November 18, 2022

Editorial
Leveraging genetic ancestry to study severe asthma exacerbations in an admixed population

Yadu Gautam, Tesfaye B Mersha

doi: 10.1136/thorax-2022-219459
Editorial
Patient registry data highlights international differences in survival in cystic fibrosis

Andrew M Jones

doi: 10.1136/thorax-2022-219600

November 11, 2022

Images in Thorax
Empyema necessitans secondary to bronchial stenting
Free

Carine J Moezinia, Hwei Ming Choo, Hussein Chreif, Yasser Madani

doi: 10.1136/thorax-2022-219469
Editorial
Environmental exposures: another effect on sphingolipids in asthma?

Stefan Worgall

doi: 10.1136/thorax-2022-219479
Respiratory infection
Prognostic significance of radiological pleuroparenchymal fibroelastosis in Mycobacterium avium complex lung disease: a multicentre retrospective cohort study

Yuya Aono, Hironao Hozumi, Masato Kono, Dai Hashimoto, Hidenori Nakamura, Koshi Yokomura, Shiro Imokawa, Masahiro Shirai, Daisuke Akahori, Yusuke Inoue, Kazutaka Mori, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda

doi: 10.1136/thorax-2022-219116

November 10, 2022

Occupational lung disease
Rate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers

Danila Azzolina, Dario Consonni, Daniela Ferrante, Dario Mirabelli, Stefano Silvestri, Ferdinando Luberto, Alessia Angelini, Francesco Cuccaro, Anna Maria Nannavecchia, Enrico Oddone, Massimo Vicentini, Francesco Barone-Adesi, Tiziana Cena, Lucia Mangone, Francesca Roncaglia, Orietta Sala, Simona Menegozzo, Roberta Pirastu, Sara Tunesi, Elisabetta Chellini, Lucia Miligi, Patrizia Perticaroli, Aldo Pettinari, Vittoria Bressan, Enzo Merler, Paolo Girardi, Lucia Bisceglia, Alessandro Marinaccio, Stefania Massari, Corrado Magnani The working group

doi: 10.1136/thorax-2021-217862

November 09, 2022

Tuberculosis
Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Danilo Buonsenso, Antoni Noguera-Julian, Rossana Moroni, Angel Hernández-Bartolomé, Nora Fritschi, Laura Lancella, Laura Cursi, Aleix Soler-Garcia, Renate Krüger, Cornelia Feiterna-Sperling, Michela Sali, Andrea Lo Vecchio, Sara Scarano, Alicia Hernanz Lobo, Maria Espiau, Antonio Soriano-Arandes, Benhur Sirvan Cetin, Folke Brinkmann, Iveta Ozere, Fernando Baquero-Artigao, Maria Tsolia, Tiago Milheiro Silva, Matilde Bustillo-Alonso, Andrea Martín Nalda, Margherita Mancini, Anna Starshinova, Nicole Ritz, Svetlana Velizarova, Laura Ferreras-Antolín, Florian Götzinger, Olga Bilogortseva, Vira Chechenyeva, Marc Tebruegge, Begoña Santiago-García ptbnet QFT-Plus study group

doi: 10.1136/thorax-2022-218929

November 08, 2022

Lung cancer
Impact of radiographer immediate reporting of X-rays of the chest from general practice on the lung cancer pathway (radioX): a randomised controlled trial

Nick Woznitza, Bhagabati Ghimire, Anand Devaraj, Sam M Janes, Keith Piper, Susan Rowe, Angshu Bhowmik, Natasha Hayes, Daniel Togher, Nikita Arumalla, Erik Skyllberg, Iain T H Au-Yong, Susan Geary, Bindu George, Sarah Sheard, Stephen Ellis, Zoheb Shah, Sue Maughn, Stephen W Duffy, David Baldwin

doi: 10.1136/thorax-2022-219210

November 07, 2022

Asthma
Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma

Venkata Sita Rama Raju Allam, Stelios Pavlidis, Gang Liu, Nazanin Zounemat Kermani, Jennifer Simpson, Joyce To, Sheila Donnelly, Yi-Ke Guo, Philip M Hansbro, Simon Phipps, Eric F Morand, Ratko Djukanovic, Peter Sterk, Kian Fan Chung, Ian Adcock, James Harris, Maria B Sukkar

doi: 10.1136/thorax-2021-218555

November 03, 2022

Editorial
Inventing the wheel: understanding heterogeneity of response to skeletal muscle dysfunction interventions in women with COPD

Merry-Lynn N McDonald

doi: 10.1136/thorax-2022-219586

October 31, 2022

Chronic obstructive pulmonary disease
Frequency and severity of respiratory infections prior to COPD diagnosis and risk of subsequent postdiagnosis COPD exacerbations and mortality: EXACOS-UK health care data study

Hannah Whittaker, Clementine Nordon, Annalisa Rubino, Tamsin Morris, Yang Xu, Enrico De Nigris, Hana Müllerová, Jennifer K Quint

doi: 10.1136/thorax-2022-219039

October 25, 2022

Skeletal muscle
Selective androgen receptor modulation for muscle weakness in chronic obstructive pulmonary disease: a randomised control trial

Divya Mohan, Harry Rossiter, Henrik Watz, Charles Fogarty, Rachael A Evans, William Man, Maggie Tabberer, Misba Beerahee, Subramanya Kumar, Helen Millns, Sebin Thomas, Ruth Tal-Singer, Alan J Russell, Marie Claire Holland, Chika Akinseye, David Neil, Michael I Polkey

doi: 10.1136/thorax-2021-218360

October 21, 2022

Editorial
Time to move out of the shadows: ILA in patients with lung cancer

Jonathan A Rose, Gary M Hunninghake

doi: 10.1136/thorax-2022-219498

October 19, 2022

Editorial
Mitochondria in diseases: from cell power plants to DAMPs

Justine Devulder

doi: 10.1136/thorax-2022-219076
Interstitial lung disease
Mediators of systemic sclerosis-associated interstitial lung disease (SSc-ILD): systematic review and meta-analyses

Aislin Fields, Koray N Potel, Rhandel Cabuhal, Buena Aziri, Iain D Stewart, Bettina C Schock

doi: 10.1136/thorax-2022-219226
Case based discussion
Benign but fatal: management of endotracheal Rosai-Dorfman disease with acute onset

Bin Wang, Zhi-min Song, Jin-dong Li, Yin-long Zhao, Ping-li Sun, Jia-kun Tian, Jin-zhi Yin, Yan Zhang

doi: 10.1136/thorax-2022-219092

October 18, 2022

Editorial
COP27 climate change conference: urgent action needed for Africa and the world

Chris Zielinski On behalf of the authorship group listed below

doi: 10.1136/thorax-2022-219740

October 10, 2022

Interstitial lung disease
Integrative analyses for the identification of idiopathic pulmonary fibrosis-associated genes and shared loci with other diseases

Ming Chen, Yiliang Zhang, Taylor Adams, Dingjue Ji, Wei Jiang, Louise V Wain, Michael Cho, Naftali Kaminski, Hongyu Zhao

doi: 10.1136/thorax-2021-217703

October 07, 2022

Images in Thorax
Transient visual loss following CT-guided percutaneous core needle biopsy of a lung lesion
Free

Karina Bennett, Karla Totton, Arianna Misacas, Fiona Caswell, David Miller

doi: 10.1136/thorax-2022-219314

October 05, 2022

Critical care
Acute hypoxaemic respiratory failure after treatment with lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal: long-term outcomes from the REST randomised trial

Andrew J Boyle, Clíona McDowell, Ashley Agus, Danielle Logan, Jonathan D Stewart, Colette Jackson, Jeanette Mills, James J McNamee, Daniel F McAuley

doi: 10.1136/thorax-2022-218874

October 03, 2022

Editorial
Perioperative rehabilitation in thoracic surgery: get up and go!

Edward Caruana, Michael C Steiner

doi: 10.1136/thorax-2022-219474

September 30, 2022

Pleural disease
Differentiation of malignant from benign pleural effusions based on artificial intelligence

Sufei Wang, Xueyun Tan, Piqiang Li, Qianqian Fan, Hui Xia, Shan Tian, Feng Pan, Na Zhan, Rong Yu, Liang Zhang, Yanran Duan, Juanjuan Xu, Yanling Ma, Wenjuan Chen, Yan Li, Zilin Zhao, Chaoyang Liu, Qingjia Bao, Lian Yang, Yang Jin

doi: 10.1136/thorax-2021-218581
Asthma
Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth

Esther Herrera-Luis, Angel C Y Mak, Javier Perez-Garcia, Elena Martin-Gonzalez, Celeste Eng, Kenneth B Beckman, Scott Huntsman, Donglei Hu, Ruperto González-Pérez, José M Hernández-Pérez, Elena Mederos-Luis, Yang Yie Sio, Paloma Poza-Guedes, Olaia Sardón, Paula Corcuera, Inmaculada Sánchez-Machín, Javier Korta-Murua, Carlos Martínez-Rivera, Joaquim Mullol, Xavier Muñoz, Antonio Valero, Joaquin Sastre, Judith Garcia-Aymerich, Sabrina Llop, Maties Torrent, Maribel Casas, José R Rodríguez-Santana, Jesús Villar, Victoria del Pozo, Fabian Lorenzo-Diaz, L Keoki Williams, Erik Melén, Fook Tim Chew, Luisa N Borrell, Esteban G Burchard, Maria Pino-Yanes

doi: 10.1136/thorax-2022-218755
Editorial
Role of physical activity and airway clearance therapy in cystic fibrosis: moving forward in a rapidly changing landscape

Thomas Radtke

doi: 10.1136/thorax-2022-219429
Cystic fibrosis
Web-based physical activity promotion in young people with CF: a randomised controlled trial

Narelle S Cox, Beverley Eldridge, Sarah Rawlings, Julianna Dreger, Jennifer Corda, Jennifer Hauser, Brenda M Button, Jennifer R Bishop, Amanda Nichols, Anna Middleton, Nathan Ward, Tiffany Dwyer, Ruth Dentice, Raynuka Lazarus, Paul O'Halloran, Joanna Y T Lee, Christie Mellerick, Kelly Mackintosh, Melitta McNarry, Craig Anthony Williams, Anne E Holland On behalf of Youth Activity Unlimited – A Strategic Research Centre of the UK Cystic Fibrosis Trust

doi: 10.1136/thorax-2022-218702

September 29, 2022

Images in Thorax
Novel inhaled antifungal for pseudomembranous Aspergillus tracheobronchitis complicating connective tissue disease

Shivani Singh, Luke S P Moore, Nabeela Mughal, Matthew Ho, Darius Armstrong-James, Suveer Singh

doi: 10.1136/thorax-2021-218375

September 27, 2022

Editorial
Changing practice by changing pressures: a role for oscillating positive expiratory pressure in chronic obstructive pulmonary disease

Adam Lewis, Christian Robert Osadnik

doi: 10.1136/thorax-2022-219451

September 15, 2022

Tuberculosis
Reduced lung function and health-related quality of life after treatment for pulmonary tuberculosis in Gambian children: a cross-sectional comparative study

Esin Nkereuwem, Schadrac Agbla, Azeezat Sallahdeen, Olumuyiwa Owolabi, Abdou K Sillah, Monica Genekah, Abdoulie Tunkara, Sheriff Kandeh, Maryama Jawara, Lamin Saidy, Andrew Bush, Toyin Togun, Beate Kampmann

doi: 10.1136/thorax-2022-219085
Cystic fibrosis
Beyond borders: cystic fibrosis survival between Australia, Canada, France and New Zealand

Adèle Coriati, Xiayi Ma, Jenna Sykes, Sanja Stanojevic, Rasa Ruseckaite, Lydie Lemonnier, Clémence Dehillotte, Jan Tate, Catherine Ann Byrnes, Scott C Bell, Pierre Regis Burgel, Anne L Stephenson

doi: 10.1136/thorax-2022-219086

September 09, 2022

Brief communication
Exercise as airway clearance therapy (ExACT) in cystic fibrosis: a UK-based e-Delphi survey of patients, caregivers and health professionals

Zoe Louise Saynor, Steve Cunningham, Lisa Morrison, Eleanor Main, Ioannis Vogiatzis, Simon Reid, Donald Urquhart

doi: 10.1136/thorax-2022-219213

September 08, 2022

Asthma
Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study

Seyi Soremekun, Liam G Heaney, Derek Skinner, Lakmini Bulathsinhala, Victoria Carter, Isha Chaudhry, Naeimeh Hosseini, Neva Eleangovan, Ruth Murray, Trung N Tran, Benjamin Emmanuel, Esther Garcia Gil, Andrew Menzies-Gow, Matthew Peters, Njira Lugogo, Rupert Jones, David B Price

doi: 10.1136/thorax-2021-217032
Images in Thorax
Pulmonary arterio-venous malformation on endobronchial ultrasound bronchoscopy
Free

Nishant Kumar Chauhan, Rengarajan Rajagopal, Benhur Joel Shadrach, Naveen Dutt

doi: 10.1136/thorax-2022-219398
Case based discussion
Case-based discussion: neonates on extracorporeal membrane oxygenation for undiagnosed recalcitrant pulmonary hypertension—management challenges

John A King, Ajay Desai, Tom Semple, Andrew G Nicholson, Andrew Bush, Samatha Sonnappa

doi: 10.1136/thorax-2021-217857

September 07, 2022

Editorial
Implementing non-invasive ventilation at home: the frontier for chronic respiratory failure?

Mark E Howard, Anna Ridgers

doi: 10.1136/thorax-2022-219480
Sleep
Randomised, controlled crossover trial of intermittent and continuous transcutaneous electrical stimulation of the genioglossus muscle for obstructive sleep apnoea

Xiaofeng Wu, Dong Zhao, Weihua Hu, Zhishui Zheng, Shiqian Zha, Qingfeng Zhang, Ke Hu

doi: 10.1136/thorax-2021-218277
Brief communication
Lymphangioleiomyomatosis (LAM) Cell Atlas

Yina Du, Minzhe Guo, Yixin Wu, Andrew Wagner, Anne Karina Perl, Kathryn Wikenheiser-Brokamp, Jane Yu, Nishant Gupta, Elizabeth Kopras, Vera Krymskaya, Kseniya Obraztsova, Yan Tang, David Kwiatkowski, Elizabeth P Henske, Francis McCormack, Yan Xu

doi: 10.1136/thoraxjnl-2022-218772

September 05, 2022

Critical care
Population study on diagnosis, treatment and outcomes of critically ill patients with tuberculosis (2008–2018)

Christina So, Lowell Ling, Wai Tat Wong, Jack Zhenhe Zhang, Chun Ming Ho, Pauline Yeung Ng, Hoi Ping Shum, Alwin Wai Tak Yeung, Kai Cheuk Sin, Jacky Chan, Ka Fai Au, Ting Liong, Eunise Ho, Fu Loi Chow, Laptin Ho, Kai Man Chan, Gavin Matthew Joynt

doi: 10.1136/thorax-2022-218868

September 02, 2022

Non-invasive ventilation
Cost-effectiveness of outpatient versus inpatient non-invasive ventilation setup in obesity hypoventilation syndrome: the OPIP trial

Patrick Brian Murphy, Maxime Patout, Gill Arbane, Swapna Mandal, Georgios Kaltsakas, Michael I Polkey, Mark Elliott, Jean-François Muir, Abdel Douiri, David Parkin, Jean-Paul Janssens, Jean Louis Pépin, Antoine Cuvelier, Clare Flach, Nicholas Hart

doi: 10.1136/thorax-2021-218497

September 01, 2022

Brief communication
Quality of life in patients with slowly progressive neuromuscular disorders dependent on mechanical ventilation

Mathieu Delorme, Christian Reveillere, Christian Devaux, Sandrine Segovia-Kueny, Frédéric Lofaso, Ghilas Boussaid

doi: 10.1136/thorax-2022-219211

August 15, 2022

Respiratory research
Optimising breathlessness triggered services for older people with advanced diseases: a multicentre economic study (OPTBreathe)

Deokhee Yi, Charles C Reilly, Gao Wei, Irene J Higginson on behalf of OPTBreathe collaborators

doi: 10.1136/thoraxjnl-2021-218251

August 10, 2022

Chronic obstructive pulmonary disease
Oscillatory positive expiratory pressure therapy in COPD (O-COPD): a randomised controlled trial

Saeed M Alghamdi, Abdullah S Alsulayyim, Ali M Alasmari, Keir E J Philip, Sara C Buttery, Winston A S Banya, Michael I Polkey, Surinder S Birring, Nicholas S Hopkinson

doi: 10.1136/thorax-2022-219077
Respiratory research
Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis

Yue Su, Johnatas Dutra Silva, Declan Doherty, David A Simpson, Daniel J Weiss, Sara Rolandsson-Enes, Daniel F McAuley, Cecilia M O'Kane, Derek P Brazil, Anna D Krasnodembskaya

doi: 10.1136/thoraxjnl-2021-218194

August 05, 2022

Interstitial lung disease
MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study

John S Kim, Ani W Manichaikul, Eric A Hoffman, Pallavi Balte, Michaela R Anderson, Elana J Bernstein, Purnema Madahar, Elizabeth C Oelsner, Steven M Kawut, Artur Wysoczanski, Andrew F Laine, Ayodeji Adegunsoye, Jennie Z Ma, Margaret A Taub, Rasika A Mathias, Stephen S Rich, Jerome I Rotter, Imre Noth, Christine Kim Garcia, R Graham Barr, Anna J Podolanczuk

doi: 10.1136/thorax-2021-218139

July 30, 2022

Asthma
Preterm or early term birth and long-term risk of asthma into midadulthood: a national cohort and cosibling study

Casey Crump, Jan Sundquist, Kristina Sundquist

doi: 10.1136/thorax-2022-218931

July 27, 2022

Respiratory epidemiology
Patient outcomes following emergency admission to hospital for COVID-19 compared with influenza: retrospective cohort study

Thomas Woodcock, Geva Greenfield, Ajit Lalvani, Azeem Majeed, Paul Aylin

doi: 10.1136/thoraxjnl-2021-217858

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