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Online First

May 11, 2021

Cystic fibrosis
Lung function in children with cystic fibrosis in the USA and UK: a comparative longitudinal analysis of national registry data

Daniela K Schlüter, Josh S Ostrenga, Siobhán B Carr, Aliza K Fink, Albert Faro, Rhonda D Szczesniak, Ruth H Keogh, Susan C Charman, Bruce C Marshall, Christopher H Goss, David Taylor-Robinson

doi: 10.1136/thoraxjnl-2021-216849
Brief communication
Chronic airflow obstruction and ambient particulate air pollution

Andre F S Amaral, Peter G J Burney, Jaymini Patel, Cosetta Minelli, Filip Mejza, David M Mannino, Terence A R Seemungal, Padukudru Anand Mahesh, Li Cher Lo, Christer Janson, Sanjay Juvekar, Meriam Denguezli, Imed Harrabi, Emiel F M Wouters, Hamid Cherkaski, Kevin Mortimer, Rain Jogi, Eric D Bateman, Elaine Fuertes, Mohammed Al Ghobain, Wan Tan, Daniel O Obaseki, Asma El Sony, Michael Studnicka, Althea Aquart-Stewart, Parvaiz Koul, Herve Lawin, Asaad Ahmed Nafees, Olayemi Awopeju, Gregory E Erhabor, Thorarinn Gislason, Tobias Welte, Amund Gulsvik, Rune Nielsen, Louisa Gnatiuc, Ali Kocabas, Guy B Marks, Talant Sooronbaev, Bertrand Hugo Mbatchou Ngahane, Cristina Barbara, A Sonia Buist The BOLD (Burden of Obstructive Lung Disease) Collaborative Research Group

doi: 10.1136/thoraxjnl-2020-216223

May 10, 2021

Chest clinic
A rare cause of an 18F-FDG positron emission tomography-positive lung lesion: look for what was lost…

Ellen Adams, Nico Mollet, Patrick Dewachter, Lynn Decoster

doi: 10.1136/thoraxjnl-2021-216919
Sleep
New forehead device in positional obstructive sleep apnoea: a randomised clinical trial

Laura Hidalgo Armas, Sandra Ingles, Rafaela Vaca, Jose Cordero-Guevara, Joaquin Duran Carro, Jorge Ullate, Ferran Barbé, Joaquin Durán-Cantolla on behalf of the Spanish Sleep Network

doi: 10.1136/thoraxjnl-2020-216167
Editorial
Further evidence that sex matters in lung development: maternal asthma and infant lung function

Lauren Deanna Benton, Wayne Morgan

doi: 10.1136/thoraxjnl-2021-217095
Chronic obstructive pulmonary disease
Bronchial gene expression signature associated with rate of subsequent FEV₁ decline in individuals with and at risk of COPD

Elizabeth J Becker, Alen Faiz, Maarten van den Berge, Wim Timens, Pieter S Hiemstra, Kristopher Clark, Gang Liu, Xiaohui Xiao, Yuriy O Alekseyev, George O'Connor, Stephen Lam, Avrum Spira, Marc E Lenburg, Katrina Steiling

doi: 10.1136/thoraxjnl-2019-214476

May 07, 2021

Asthma
The effect of diet in infancy on asthma in young adults: the Merthyr Allergy Prevention Study
Free

Sadiyah Hand, Frank Dunstan, Ken Jones, Iolo Doull

doi: 10.1136/thoraxjnl-2020-215040
Pulmonary vasculature
Loss of immune homeostasis in patients with idiopathic pulmonary arterial hypertension

Peter Heukels, Odilia B J Corneth, Denise van Uden, Jennifer A C van Hulst, Leon M van den Toorn, Annemien E van den Bosch, Marlies S Wijsenbeek, Karin A Boomars, Mirjam Kool, Rudi W Hendriks

doi: 10.1136/thoraxjnl-2020-215460
Respiratory research
Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin

Sinjini Sikdar, Annah B Wyss, Mi Kyeong Lee, Thanh T Hoang, Marie Richards, Laura E Beane Freeman, Christine Parks, Peter S Thorne, John L Hankinson, David M Umbach, Alison Motsinger-Reif, Stephanie J London

doi: 10.1136/thoraxjnl-2020-215624
Images in Thorax
The curious incident of the cast in the airway
Free

Yueqi Ge, Emily C Bartlett, Thomas Semple, Alexandra Rice, Anand Shah, Elisabetta A Renzoni

doi: 10.1136/thoraxjnl-2020-216426
Paediatric lung disease
Effect of nusinersen on respiratory function in paediatric spinal muscular atrophy types 1–3

Archana Chacko, Peter D Sly, Robert S Ware, Nelufa Begum, Sean Deegan, Nicole Thomas, Leanne M Gauld

doi: 10.1136/thoraxjnl-2020-216564

April 30, 2021

Critical care
Functional electrical stimulation‐assisted cycle ergometry-based progressive mobility programme for mechanically ventilated patients: randomised controlled trial with 6 months follow-up

Petr Waldauf, Natália Hrušková, Barbora Blahutova, Jan Gojda, Tomáš Urban, Adéla Krajčová, Michal Fric, Kateřina Jiroutková, Kamila Řasová, František Duška

doi: 10.1136/thoraxjnl-2020-215755

April 29, 2021

Respiratory epidemiology
Relationship between heart failure and the risk of acute exacerbation of COPD

Eleanor L Axson, Alex Bottle, Martin R Cowie, Jennifer K Quint

doi: 10.1136/thoraxjnl-2020-216390
Editorial
Exposure to pesticides and chronic respiratory health effects: what is the link?

Rachel Raanan

doi: 10.1136/thoraxjnl-2020-216626
Respiratory research
High-flow nasal cannula oxygen therapy for outpatients undergoing flexible bronchoscopy: a randomised controlled trial

Federico Longhini, Corrado Pelaia, Eugenio Garofalo, Andrea Bruni, Roberta Placida, Caterina Iaquinta, Eugenio Arrighi, Graziella Perri, Giada Procopio, Anna Cancelliere, Serena Rovida, Giuseppina Marrazzo, Girolamo Pelaia, Paolo Navalesi

doi: 10.1136/thoraxjnl-2021-217116
Respiratory infection
Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score

Juan Berenguer, Alberto M Borobia, Pablo Ryan, Jesús Rodríguez-Baño, Jose M Bellón, Inmaculada Jarrín, Jordi Carratalà, Jerónimo Pachón, Antonio J Carcas, María Yllescas, José R Arribas COVID-19@Spain and COVID@HULP Study Groups

doi: 10.1136/thoraxjnl-2020-216001
Interstitial lung disease
Nocturnal hypoxaemia in interstitial lung disease: a systematic review

Yet Hong Khor, Yvonne Ng, Duncan Sweeney, Christopher J Ryerson

doi: 10.1136/thoraxjnl-2020-216749
Critical care
Association of imbalance between job workload and functional ability with return to work in ARDS survivors

Han Su, Ramona Hopkins, Biren Bharat Kamdar, Susanne May, Victor D Dinglas, Kurt L Johnson, Megan Hosey, Catherine L Hough, Dale M Needham, Hilaire J Thompson

doi: 10.1136/thoraxjnl-2020-216586
Editorial
Blowing hot and cold over asthma hospitalisations

Liuhua Shi

doi: 10.1136/thoraxjnl-2021-217178
Editorial
Huff and puff of exercise for airway clearance in cystic fibrosis: how clear is the evidence?

Tiffany Dwyer

doi: 10.1136/thoraxjnl-2020-216622
Brief communication
Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length

Claire F McGroder, David Zhang, Mohammad A Choudhury, Mary M Salvatore, Belinda M D'Souza, Eric A Hoffman, Ying Wei, Matthew R Baldwin, Christine Kim Garcia

doi: 10.1136/thoraxjnl-2021-217031
State of the art review
Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis

Katie J Bayfield, Tonya A Douglas, Tim Rosenow, Jane Carolyn Davies, Stuart J Elborn, Marcus Mall, Anthony Paproki, Felix Ratjen, Peter D Sly, Alan Robert Smyth, Stephen Stick, Claire E Wainwright, Paul D Robinson

doi: 10.1136/thoraxjnl-2020-216085

April 26, 2021

Respiratory infection
Shift work is associated with positive COVID-19 status in hospitalised patients

Robert Maidstone, Simon G Anderson, David W Ray, Martin K Rutter, Hannah J Durrington, John F Blaikley

doi: 10.1136/thoraxjnl-2020-216651
Images in Thorax
A rare condition masquerading as lung cancer
Free

Eman Nasr, Sarah MacRae, Mike Dobson, David Russell, Mohamad Bittar

doi: 10.1136/thoraxjnl-2020-216689

April 23, 2021

Tuberculosis
Timing of Mycobacterium tuberculosis exposure explains variation in BCG effectiveness: a systematic review and meta-analysis

James M Trauer, Andrew Kawai, Anna K Coussens, Manjula Datta, Bridget M Williams, Emma S McBryde, Romain Ragonnet

doi: 10.1136/thoraxjnl-2020-216794
Brief communication
Impact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: the SUR-VAPES Chronic Study

Lorenzo Loffredo, Roberto Carnevale, Simona Battaglia, Roberta Marti, Stefano Pizzolo, Simona Bartimoccia, Cristina Nocella, Vittoria Cammisotto, Sebastiano Sciarretta, Isotta Chimenti, Elena De Falco, Elena Cavarretta, Mariangela Peruzzi, Antonino Marullo, Fabio Miraldi, Francesco Violi, Andrea Morelli, Giuseppe Biondi-Zoccai, Giacomo Frati

doi: 10.1136/thoraxjnl-2020-215900

April 22, 2021

Interstitial lung disease
Risk of drug-induced interstitial lung disease in hospitalised patients: a nested case–control study

Taisuke Jo, Nobuaki Michihata, Hayato Yamana, Kojiro Morita, Miho Ishimaru, Yasuhiro Yamauchi, Wakae Hasegawa, Hirokazu Urushiyama, Kazuaki Uda, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Takahide Nagase

doi: 10.1136/thoraxjnl-2020-215824
Brief communication
Novel recessive locus for body mass index in childhood asthma

Sanghun Lee, Jessica Lasky-Su, Sungho Won, Cecelia Laurie, Juan Carlos Celedón, Christoph Lange, Scott Weiss, Julian Hecker

doi: 10.1136/thoraxjnl-2020-215742
Critical care
Transepithelial nasal potential difference in patients with, and at risk of acute respiratory distress syndrome

Rob Mac Sweeney, Kiran Reddy, Jane C Davies, Mike Parker, Barry Kelly, J Stuart Elborn, John Conlon, Rejina M Verghis, Carolyn S Calfee, Michael A Matthay, Eric W F W Alton, Daniel F McAuley

doi: 10.1136/thoraxjnl-2020-215587
Brief communication
Circulating microbial cell-free DNA is associated with inflammatory host-responses in severe pneumonia

Haopu Yang, Ghady Haidar, Nameer S Al-Yousif, Haris Zia, Daniel Kotok, Asim A Ahmed, Lily Blair, Sudeb Dalai, Sivan Bercovici, Carine Ho, Bryan J McVerry, Alison Morris, Georgios D Kitsios

doi: 10.1136/thoraxjnl-2020-216013
Case based discussion
Acute haemoptysis, fever and abdominal pain in an adolescent from northern Australia

Daniel K Yeoh, Timothy J Ford, Joanna Chua, Miriam Bennamoun, Christopher C Blyth, Anita J Campbell, Prasanthy Hamsanathan, Ben Harkin, Jovanka King, Lisa Matthews, Charlie McLeod, Rebecca Warren, Asha C Bowen, Melanie J Thompson, André Schultz

doi: 10.1136/thoraxjnl-2020-216257

April 21, 2021

Paediatric lung disease
Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury

Alison W Ha, Tao Bai, David L Ebenezer, Tanvi Sethi, Tara Sudhadevi, Lizar Ace Mangio, Steven Garzon, Gloria S Pryhuber, Viswanathan Natarajan, Anantha Harijith

doi: 10.1136/thoraxjnl-2020-216469
Editorial
Complex interplay between greenness and air pollution in respiratory health

Elaine Fuertes, Debbie Jarvis

doi: 10.1136/thoraxjnl-2021-217272

April 19, 2021

Brief communication
Association of heated tobacco product use with tobacco use cessation in a Japanese workplace: a prospective study

Makiko Kanai, Osamu Kanai, Takahiro Tabuchi, Tadashi Mio

doi: 10.1136/thoraxjnl-2020-216253
Commentary
Cooling off the heated controversy of a safer cigarette: heat-not-burn no better than traditional combustion cigarettes

Irina Petrache, Esther de Boer

doi: 10.1136/thoraxjnl-2020-216743

April 16, 2021

Critical care
Attributable mortality of acute respiratory distress syndrome: a systematic review, meta-analysis and survival analysis using targeted minimum loss-based estimation

Lisa K Torres, Katherine L Hoffman, Clara Oromendia, Ivan Diaz, John S Harrington, Edward J Schenck, David R Price, Luis Gomez-Escobar, Angelica Higuera, Mayra Pinilla Vera, Rebecca M Baron, Laura E Fredenburgh, Jin-Won Huh, Augustine M K Choi, Ilias I Siempos

doi: 10.1136/thoraxjnl-2020-215950
Editorial
Can clinical benefits of modulators effectively ‘modulate’ adherence in people with CF?

Chelsea S Davis, Jonathan D Cogen

doi: 10.1136/thoraxjnl-2021-216974
Sleep
Pulse arrival time, a novel sleep cardiovascular marker: the multi-ethnic study of atherosclerosis

Younghoon Kwon, Christopher Wiles, B Eugene Parker, Brian R Clark, Min-Woong Sohn, Sara Mariani, Jin-Oh Hahn, David R Jacobs, James H Stein, Joao Lima, Vishesh Kapur, Andrew Wellman, Susan Redline, Ali Azarbarzin

doi: 10.1136/thoraxjnl-2020-216399

April 15, 2021

Critical care
Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis

Leanne M Aitken, Kalliopi Kydonaki, Bronagh Blackwood, Laurence G Trahair, Edward Purssell, Mandeep Sekhon, Timothy S Walsh

doi: 10.1136/thoraxjnl-2020-216098
Interstitial lung disease
Fibrotic extracellular matrix induces release of extracellular vesicles with pro-fibrotic miRNA from fibrocytes

Seidai Sato, Sy Giin Chong, Chandak Upagupta, Toyoshi Yanagihara, Takuya Saito, Chiko Shimbori, Pierre-Simon Bellaye, Yasuhiko Nishioka, Martin RJ Kolb

doi: 10.1136/thoraxjnl-2020-215962
Brief communication
Inhaled nitric oxide improves the hepatopulmonary syndrome: a physiologic analysis

Samir Gupta, Rosalind Tang, Abdul Al-Hesayen

doi: 10.1136/thoraxjnl-2020-216128
Brief communication
Genetic polymorphism in ATIC is associated with effectiveness and toxicity of pemetrexed in non-small-cell lung cancer

Sabine Visser, Stijn Koolen, Nadine van Donk, Nico van Walree, Cor van der Leest, Robin Cornelissen, Ron van Schaik, Ron Mathijssen, Joachim Aerts, Bruno H Stricker

doi: 10.1136/thoraxjnl-2020-216504
Controversies and challenges in respiratory medicine
Functional respiratory assessment: some key misconceptions and their clinical implications

José Alberto Neder

doi: 10.1136/thoraxjnl-2020-215287
Brief communication
Rectal organoid morphology analysis (ROMA) as a promising diagnostic tool in cystic fibrosis

Senne Cuyx, Anabela Santo Ramalho, Nikky Corthout, Steffen Fieuws, Eva Fürstová, Kaline Arnauts, Marc Ferrante, Catherine Verfaillie, Sebastian Munck, Mieke Boon, Marijke Proesmans, Lieven Dupont, Kris De Boeck, François Vermeulen On behalf of the Belgian Organoid Project

doi: 10.1136/thoraxjnl-2020-216368
Lung cancer
Lung cancer probability and clinical outcomes of baseline and new subsolid nodules detected on low-dose CT screening

Yeon Wook Kim, Byoung Soo Kwon, Sung Yoon Lim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Kyung Won Lee, Jae Ho Lee, Jin-Haeng Chung, Eunjeong Ji, Choon-Taek Lee

doi: 10.1136/thoraxjnl-2020-215107
Brief communication
Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema

H Laura Aaltonen, Madeleine Petersson Sjögren, Jonas K F Jakobsson, Hanna Nicklasson, Sandra Diaz, Francisco Sánchez Montiel, Sophia Zackrisson, Veronica Ideböhn, Gunnar Engström, Jakob Löndahl, Per Wollmer

doi: 10.1136/thoraxjnl-2020-214523
Non-invasive ventilation
Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis

Marius Lebret, Antoine Léotard, Jean Louis Pépin, Wolfram Windisch, Emelie Ekkernkamp, Mercedes Pallero, M-Ángeles Sánchez-Quiroga, Nicholas Hart, Julia L Kelly, Maxime Patout, Georg Chistian Funk, Marieke L Duiverman, Juan F Masa, Anita Simonds, Patrick Brian Murphy, Peter J Wijkstra, Michael Dreher, Jan Storre, Charles Khouri, Jean-Christian Borel

doi: 10.1136/thoraxjnl-2020-215613

April 12, 2021

Respiratory infection
Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19

Anno Saris, Tom DY Reijnders, Esther J Nossent, Alex R Schuurman, Jan Verhoeff, Saskia van Asten, Hetty Bontkes, Siebe Blok, Janwillem Duitman, Harm-Jan Bogaard, Leo Heunks, Rene Lutter, Tom van der Poll, Juan J Garcia Vallejo ArtDECO consortium and the Amsterdam UMC COVID study group

doi: 10.1136/thoraxjnl-2020-216256

April 09, 2021

Editorial
Improved asthma control during the COVID-19 pandemic: are there lessons to be learnt?
Free

Imogen P Skene, Paul E Pfeffer

doi: 10.1136/thoraxjnl-2021-216930
Controversies and challenges in respiratory medicine
COVID-19 and ethnicity:has history repeated itself?
Free

Annastazia E Learoyd, Abdel Douiri, Nicholas Hart

doi: 10.1136/thoraxjnl-2021-216992

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