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Effects of non-invasive ventilation on sleep in chronic hypercapnic respiratory failure
  1. Neeraj M Shah1,2,
  2. Joerg Steier1,2,
  3. Nicholas Hart1,2,
  4. Georgios Kaltsakas1,2
  1. 1Lane Fox Clinical Respiratory Physiology Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK
  2. 2Centre for Human and Applied Physiological Sciences (CHAPS), King’s College London, London, UK
  1. Correspondence to Dr Georgios Kaltsakas, Lane Fox Clinical Respiratory Physiology Research Centre, King's College London Centre for Human & Applied Physiological Sciences, London, SE1 7EH, UK; Georgios.Kaltsakas{at}


Chronic respiratory disease can exacerbate the normal physiological changes in ventilation observed in healthy individuals during sleep, leading to sleep-disordered breathing, nocturnal hypoventilation, sleep disruption and chronic respiratory failure. Therefore, patients with obesity, slowly and rapidly progressive neuromuscular disease and chronic obstructive airways disease report poor sleep quality. Non-invasive ventilation (NIV) is a complex intervention used to treat sleep-disordered breathing and nocturnal hypoventilation with overnight physiological studies demonstrating improvement in sleep-disordered breathing and nocturnal hypoventilation, and clinical trials demonstrating improved outcomes for patients. However, the impact on subjective and objective sleep quality is dependent on the tools used to measure sleep quality and the patient population. As home NIV becomes more commonly used, there is a need to conduct studies focused on sleep quality, and the relationship between sleep quality and health-related quality of life, in all patient groups, in order to allow the clinician to provide clear patient-centred information.

  • Non invasive ventilation
  • Respiratory Muscles
  • Sleep apnoea
  • Assisted Ventilation

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  • Contributors All authors engaged into discussions related to this manuscript, contributing in writting it and reviewing it.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.