Background Immediate smoking cessation interventions delivered alongside targeted lung health checks (TLHCs) to screen for lung cancer increase self-reported abstinence at 3 months. The impact on longer term, objectively confirmed quit rates remains to be established.
Methods We followed up participants from two clinical trials in people aged 55–75 years who smoked and took part in a TLHC. These randomised participants in the TLHC by day of attendance to either usual care (UC) (signposting to smoking cessation services) or an offer of immediate smoking cessation support including pharmacotherapy. In the QuLIT1 trial, this was delivered face to face and in QuLIT2, it was delivered remotely. Follow-up was conducted 12 months after the TLHC by telephone interview with subsequent biochemical verification of smoking cessation using exhaled CO.
Results 430 people were enrolled initially (115 in QuLIT1 and 315 in QuLIT2), with 4 deaths before 12 months leaving 426 (62.1±5.27 years old and 48% women) participants for analysis. At 12 months, those randomised to attend on smoking cessation support intervention days had higher quit rates compared with UC adjusted for age, gender, deprivation, and which trial they had been in; self-reported 7-day point prevalence (20.0% vs 12.8%; adjusted OR (AOR)=1.78; 95% CI 1.04 to 2.89) and CO-verified quits (12.1% vs 4.7%; AOR=2.97; 95% CI 1.38 to 6.90). Those in the intervention arm were also more likely to report having made a quit attempt (30.2% vs UC 18.5%; AOR 1.90; 95% CI 1.15 to 3.15).
Conclusion Providing immediate smoking cessation support alongside TLHC increases long term, biochemically confirmed smoking abstinence.
Trial registration number ISRCTN12455871.
- smoking cessation
- lung cancer
- tobacco and the lung
Data availability statement
Data are available upon reasonable request. Anonymised research data will be shared with third parties via request to the senior author (NSH).
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Contributors NSH, ECB, AD, SVK, JA, JD and MC designed the study. PJW and KEJP conducted follow-up calls, PJW conducted data analysis, supported by AAL and NSH. PJW produced the first draft to which all authors KEJP, SCB, AP, LC, ECB, AD, SVK, JA, JD, MC, MIP, AAL and NSH contributed. All authors have reviewed and approved the final manuscript and NSH is the guarantor.
Funding This work was supported by RM Partners, West London Cancer Alliance, hosted by The Royal Marsden NHS Foundation Trust and The Royal Brompton and Harefield Charities.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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