Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma

Venkata Sita Rama Raju Allam; Stelios Pavlidis; Gang Liu; Nazanin Zounemat Kermani; Jennifer Simpson; Joyce To; Sheila Donnelly; Yi-Ke Guo; Philip M Hansbro; Simon Phipps; Eric F Morand; Ratko Djukanovic; Peter Sterk; Kian Fan Chung; Ian Adcock; James Harris; Maria B Sukkar

doi:10.1136/thorax-2021-218555

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Asthma

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Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma

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Venkata Sita Rama Raju Allam Graduate School of Health, Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia Department of Medical Biochemistry and Microbiology, Biomedical Centre, Uppsala University, Uppsala, Sweden PubMed articles Google scholar articles
Stelios Pavlidis Data Science Institute, Imperial College London, London, UK Computational Sciences, Janssen Research and Development, High Wycombe, UK PubMed articles Google scholar articles
Gang Liu Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Nazanin Zounemat Kermani Data Science Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Jennifer Simpson Respiratory Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Joyce To School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Sheila Donnelly School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Yi-Ke Guo Data Science Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Philip M Hansbro Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Simon Phipps Respiratory Immunology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia PubMed articles Google scholar articles
Eric F Morand Centre for Inflammatory Diseases, Monash University, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Ratko Djukanovic NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK PubMed articles Google scholar articles
Peter Sterk Department of Respiratory Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands PubMed articles Google scholar articles
Kian Fan Chung Airways Disease, National Heart & Lung Institute, Imperial College London, London, UK Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, UK PubMed articles Google scholar articles
Ian Adcock Airways Disease, National Heart & Lung Institute, Imperial College London, London, UK Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, UK PubMed articles Google scholar articles
James Harris Centre for Inflammatory Diseases, Monash University, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Maria B Sukkar Graduate School of Health, Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia PubMed articles Google scholar articles

Correspondence to Associate Professor Maria B Sukkar, Graduate School of Health, Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia; maria.sukkar{at}outlook.com

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Citation

Allam VSRR, Pavlidis S, Liu G, et al

Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma

Thorax Published Online First: 07 November 2022. doi: 10.1136/thorax-2021-218555

Publication history

Received December 3, 2021
Accepted July 15, 2022
First published November 7, 2022.

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