Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

Luke M Kraven; Adam R Taylor; Philip L Molyneaux; Toby M Maher; John E McDonough; Marco Mura; Ivana V Yang; David A Schwartz; Yong Huang; Imre Noth; Shwu Fan Ma; Astrid J Yeo; William A Fahy; R Gisli Jenkins; Louise V Wain

doi:10.1136/thoraxjnl-2021-218563

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Interstitial lung disease

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Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

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Luke M Kraven Department of Health Sciences, University of Leicester, Leicester, UK Research & Development, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
Adam R Taylor Research & Development, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
Philip L Molyneaux Guy’s and St Thomas’ NHS Foundation Trust, Royal Brompton and Harefield Hospitals, London, UK National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Toby M Maher Guy’s and St Thomas’ NHS Foundation Trust, Royal Brompton and Harefield Hospitals, London, UK National Heart and Lung Institute, Imperial College London, London, UK Keck School of Medicine, University of Southern California, Los Angeles, California, USA PubMed articles Google scholar articles
John E McDonough Division of Pulmonary, Critical Care & Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, USA PubMed articles Google scholar articles
Marco Mura Division of Respirology, Western University, London, Ontario, Canada PubMed articles Google scholar articles
Ivana V Yang Department of Medicine, University of Colorado, Denver, Colorado, USA PubMed articles Google scholar articles
David A Schwartz Department of Medicine, University of Colorado, Denver, Colorado, USA PubMed articles Google scholar articles
Yong Huang Division of Pulmonary & Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Imre Noth Division of Pulmonary & Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Shwu Fan Ma Division of Pulmonary & Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA PubMed articles Google scholar articles
Astrid J Yeo Research & Development, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
William A Fahy Research & Development, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
R Gisli Jenkins National Heart and Lung Institute, Imperial College London, London, UK National Institute for Health Research Respiratory Clinical Research Facility, Royal Brompton Hospital, London, UK PubMed articles Google scholar articles
Louise V Wain Department of Health Sciences, University of Leicester, Leicester, UK National Institute for Health Research, Glenfield Hospital, Leicester, UK PubMed articles Google scholar articles

Correspondence to Dr Louise V Wain, Health Sciences, University of Leicester, Leicester, Leicestershire, UK; lvw1{at}le.ac.uk

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Kraven LM, Taylor AR, Molyneaux PL, et al

Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

Thorax 2023;78:551-558.

Publication history

Received December 8, 2021
Accepted April 14, 2022
First published May 9, 2022.

Online issue publication

October 24, 2023

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This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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