Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients’ indirect exposure to inorganic particles, through coresidents’ occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5–7) vs 0.5 (0–2), p=0.003 and 1 (0–2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.
- paediatric interstitial lung disease
- occupational lung disease
- rare lung diseases
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NN and M-EM contributed equally.
Collaborators The French Sarcoidosis Group, The Silicosis Research Group.
Contributors NN and CC designed the study. CC, OM, P-AR and MV designed the questionnaires. M-EM, CC, NN, MB, LS and FJ analysed and interpreted the data. M-EM, NN, P-AR, DV and CC wrote the manuscript.
NN, M-EM, SC, FJ, LS, RA-T, JB, CC-A, FC-A, MC, ChD, CeD, ADe, ADo, RE, JH, VH, DI-B, KJ, SL-J, FL, UM, MM, HN, SM, J-MN, M-HO, AC, DV provided the patients’ clinical data and facilitated the contacts to make the interviews with patients and SCD controls. All authors reviewed and approved the manuscript.
Funding Contract grant sponsor: European Research Council (ERC) / SILICOSIS project / Principal investigator: Paul-André Rosental; Contract grant number: ERC-2011-ADG_20110406ˆProject ID: 295817. Statistical analysis: RespiFIL funds.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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