Article Text

Download PDFPDF
Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study
  1. Nadia Nathan1,
  2. Marie-Emeline Montagne2,
  3. Odile Macchi3,
  4. Paul-André Rosental4,
  5. Simon Chauveau5,
  6. Florence Jeny5,
  7. Lucile Sesé5,
  8. Rola Abou Taam6,
  9. Manon Brocvielle7,
  10. Jacques Brouard8,
  11. Mickaël Catinon9,
  12. Catherine Chapelon-Abric10,
  13. Fleur Cohen-Aubart11,
  14. Christophe Delacourt6,
  15. Céline Delestrain12,
  16. Antoine Deschildre13,
  17. Antoine Dossier14,
  18. Ralph Epaud15,
  19. Julien Haroche11,
  20. Véronique Houdouin16,
  21. Dominique Israel-Biet17,
  22. Karine Juvin17,
  23. Sylvain Le Jeune18,
  24. Francois Lionnet19,
  25. Ulrich Meinzer20,
  26. Marie Mittaine21,
  27. Hilario Nunes5,
  28. Sarah Mattioni19,
  29. Jean-Marc Naccache22,
  30. Marie-Hélène Odièvre23,
  31. Michel Vincent9,
  32. Annick Clement1,
  33. Dominique Valeyre5,24,
  34. Catherine Cavalin25,26,27
  35. for the French Sarcoidosis Group and the Silicosis Research Group
  1. 1Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Inserm UMR_S933 Laboratory of Childhood Genetic Diseases, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France
  2. 2Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France
  3. 3Observatoire, Samu Social de Paris, Paris, France
  4. 4Centre d'Histoire, Sciences Po, Paris, France
  5. 5Pulmonology Department and Inserm UMR 127, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France
  6. 6Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Necker Enfants Malades Hospital, AP-HP. Centre - Université de Paris, Paris, France
  7. 7Statistician, Marcq-en-Baroeul, France
  8. 8Pediatric Pulmonology Department, CHU Caen, Caen, France
  9. 9MINAPATH : SAS sociale et solidaire, Lyon, France
  10. 10Department of Internal Medicine and Clinical Immunology, La Pitié-Salpêtrière Hospital, APHP. Sorbonne Université, Paris, France
  11. 11Department of Internal Medicine 2, La Pitié-Salpêtrière Hospital, e3m Institute, Reference Center for Rare Systemic Diseases, Lupus, Anti-Phospholipids Syndrome, AP-HP. Sorbonne Université, Paris, France
  12. 12Pediatric Department and Reference Center for Rare Lung Diseases RespiRare, INSERM, IMRB, Centre Hospitalier Intercommunal de Créteil, Université Paris Est Creteil, Paris, France
  13. 13Pediatric pulmonology and allergy department, Hôpital Jeanne de Flandre, Université de Lille, Lille, France
  14. 14Department of Internal Medicine, Bichat Hospital, AP-HP. Nord - Université de Paris, Paris, France
  15. 15Centre Hospitalier Intercommunal de Créteil, Pediatric Department and Reference center for rare lung diseases (RespiRare), INSERM, IMRB, Université Paris Est Creteil, Paris, France
  16. 16Pediatric Pulmonology department, Robert Debré Hospital, AP-HP. Nord - Université de Paris, Paris, France
  17. 17Pulmonology department, Georges Pompidou Hospital, AP-HP. Centre - Université de Paris, Paris, France
  18. 18Department of Internal Medicine, Avicenne Hospital, APHP. Université Sorbonne Paris Nord, Paris, France
  19. 19Department of Internal Medicine, Tenon Hospital, AP-HP. Sorbonne Université, Paris, France
  20. 20Department of General Pediatrics, Pediatric Internal Medicine, Rheumatology and Infectious Diseases, National Referee Center for Rare Pediatric Inflammatory Rheumatisms and Systemic Auto-Immune Diseases RAISE, Robert Debré Hospital, AP-HP. Nord - Université de Paris, Paris, France
  21. 21Pediatric Pulmonology Department, Children Hospital, CHU Toulouse, Toulouse, France
  22. 22Pulmonology Department, Groupe hospitalier Paris Saint-Joseph and Hôpital Foch, Paris, France
  23. 23Department of Pediatrics and Sickle Cell Disease Center, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France
  24. 24Pulmonology department, Paris Saint Joseph Hospital Group, Paris, France
  25. 25Institut de recherche interdisciplinaire en sciences sociales (IRISSO, UMR CNRS-INRA 7170-1427), Université Paris Dauphine, PSL, Paris, France
  26. 26Laboratoire interdisciplinaire d’évaluation des politiques publiques (LIEPP), Sciences Po, Paris, France
  27. 27Centre d’études de l’emploi et du travail (CEET, CNAM), CNAM, Paris, France
  1. Correspondence to Dr Nadia Nathan, Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases RespiRare, Inserm UMR_S933 Laboratory of Childhood Genetic Diseases, Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France; nadia.nathan{at}aphp.fr

Abstract

Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients’ indirect exposure to inorganic particles, through coresidents’ occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5–7) vs 0.5 (0–2), p=0.003 and 1 (0–2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.

  • sarcoidosis
  • paediatric interstitial lung disease
  • occupational lung disease
  • rare lung diseases

Statistics from Altmetric.com

Footnotes

  • NN and M-EM contributed equally.

  • Collaborators The French Sarcoidosis Group, The Silicosis Research Group.

  • Contributors NN and CC designed the study. CC, OM, P-AR and MV designed the questionnaires. M-EM, CC, NN, MB, LS and FJ analysed and interpreted the data. M-EM, NN, P-AR, DV and CC wrote the manuscript.

    NN, M-EM, SC, FJ, LS, RA-T, JB, CC-A, FC-A, MC, ChD, CeD, ADe, ADo, RE, JH, VH, DI-B, KJ, SL-J, FL, UM, MM, HN, SM, J-MN, M-HO, AC, DV provided the patients’ clinical data and facilitated the contacts to make the interviews with patients and SCD controls. All authors reviewed and approved the manuscript.

  • Funding Contract grant sponsor: European Research Council (ERC) / SILICOSIS project / Principal investigator: Paul-André Rosental; Contract grant number: ERC-2011-ADG_20110406ˆProject ID: 295817. Statistical analysis: RespiFIL funds.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles