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Contributors All authors developed the outline. ACM and KK wrote the first draft and generated the figures. All authors critically revised the manuscript for important intellectual content and agreed the final submitted version of the manuscript.
Funding MS-H is supported by the National Institute for Health Research Clinician Scientist Award (NIHR-CS-2016-16-011). ACM is supported by an MRC Clinician Scientist Fellowship (MR/V006118/1).
Disclaimer The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the UK National Institute for Health Research or the Department of Health.
Competing interests None declared.
Provenance and peer review Commissioned; externally peer reviewed.
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