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Prognostic accuracy of a peripheral blood transcriptome signature in chronic hypersensitivity pneumonitis
  1. Evans R Fernández Pérez1,
  2. Laura D Harmacek2,
  3. Brian P O'Connor2,
  4. Thomas Danhorn3,
  5. Brian Vestal2,
  6. Lisa A Maier4,
  7. Tilman L Koelsch5,
  8. Sonia M Leach2
  1. 1Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health Department of Medicine, Denver, Colorado, USA
  2. 2Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA
  3. 3Biostatistics and Bioinformatics Shared Resource, University of Colorado Cancer Center, Auroa, Colorado, USA
  4. 4Division of Occupational Health and Environmental Health Sciences, National Jewish Health Department of Medicine, Denver, Colorado, USA
  5. 5Thoracic Radiology, National Jewish Health, Denver, Colorado, USA
  1. Correspondence to Dr Evans R Fernández Pérez, Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health Department of Medicine, Denver, Colorado, USA; fernandezevans{at}njhealth.org

Abstract

The prognostic value of peripheral blood mononuclear cell (PBMC) expression profiles, when used in patients with chronic hypersensitivity pneumonitis (CHP), as an adjunct to traditional clinical assessment is unknown. RNA-seq analysis on PBMC from 37 patients with CHP at initial presentation determined that (1) 74 differentially expressed transcripts at a 10% false discovery rate distinguished those with (n=10) and without (n=27) disease progression, defined as absolute FVC and/or diffusing capacity of the lungs for carbon monoxide (DLCO) decline of ≥10% and increased fibrosis on chest CT images within 24 months, and (2) classification models based on gene expression and clinical factors strongly outperform models based solely on clinical factors (baseline FVC%, DLCO% and chest CT fibrosis).

  • hypersensitivity pneumonitis

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Footnotes

  • Contributors ERFP, LDH, BPO'C, TD and SML were involved in study conception and design. Data collection, analysis and drafting the manuscript for important intellectual content were done by ERFP, BV, LDH, BPO'C, LAM, TD, TLK and SML.

  • Funding Supported by NIH/NHLBI grant R01HL148437, a National Jewish Health grant as well as by a generous donation from Forrest Shook.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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