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Evolutive diaphragmatic lesions causing recurrent catamenial pneumothorax
  1. Céline Forster1,2,
  2. Charles Bénière3,
  3. Justine Lattion1,
  4. Jean Yannis Perentes1,2,
  5. Michel Christodoulou1
  1. 1Thoracic Surgery, Valais Hospital, Sion, Switzerland
  2. 2Thoracic Surgery, Lausanne University Hospital, Lausanne, Switzerland
  3. 3Pathology, Valais Hospital, Sion, Switzerland
  1. Correspondence to Dr Céline Forster, Thoracic Surgery, Valais Hospital, Sion 1951, Switzerland; celine.forster{at}hopitalvs.ch

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A 47-year-old woman was diagnosed with pelvic endometriosis during a caesarean at the age of 37 years. Two years later, she presented two episodes of spontaneous right-sided pneumothorax occurring 2 days after the onset of her menses. The first episode was treated with pleural drainage and the chest CT scan did not show parenchymal or diaphragmatic anomalies. A second episode occurred 1 month later and the patient underwent thoracoscopic exploration, wedge resection of the lung apex and mechanical pleurodesis. During this intervention, multiple dark elliptical nodules were identified on the tendinous part of the diaphragm (figure 1A) and biopsies confirmed the presence of endometriosis (figure 1B,C). Since then, a progestin therapy (dienogest) was introduced at a daily dosage of 2 mg. Eight years later, the patient presented a third episode of right-sided pneumothorax. A thoracoscopic re-exploration was performed and multiple small elliptical perforations were identified on the tendinous part of the diaphragm, at the same location where endometriosis nodules had initially been observed (figure 2). A talc pleurodesis was performed and since then, the patient did not present any recurrence with an ongoing daily treatment of 2 mg dienogest.

Figure 1

(A) Multiple dark epiphrenic nodules found during thoracoscopic exploration for catamenial pneumothorax. (B) Histological assessment of a biopsied nodule revealing typical endometrial gland tissue with fibrous reaction (H&E ×100) with (C) positive immunohistochemical staining for CD10 within the stroma (×200).

Figure 2

Thoracoscopic evaluation in the same patient on the same side performed 8 years after the first intervention for recurrent catamenial pneumothorax revealing multiple small elliptic diaphragmatic perforations at the site of the initially localised epiphrenic endometrial nodules.

Thoracic endometriosis can cause recurrent, preferentially right-sided catamenial pneumothorax, which is often associated with multiple small diaphragmatic defects situated in the tendinous part of the diaphragm as well as endometrial implants within the chest cavity.1 2 This report clearly demonstrates (and to our knowledge for the first time) that epiphrenic endometrial implants have erosive properties with subsequent development of diaphragmatic defects causing recurrent pneumothorax. These findings have to be taken into consideration for the management of this relatively rare entity, which is ideally approached in an interdisciplinary setting.

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Footnotes

  • Contributors CF, JL, JYP and MC contributed to the planning and writing of the article. CB provided figures. All authors reviewed the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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