Various forms of diffuse parenchymal lung disease have been proposed as potential consequences of severe COVID‑19. We describe the clinical, radiological and histological findings of patients with COVID‑19-associated acute respiratory distress syndrome who later developed severe organising pneumonia including longitudinal follow-up. Our findings may have important implications for the therapeutic modalities in the late-phase of severe COVID‑19 and might partially explain why a subgroup of COVID‑19 patients benefits from systemic corticosteroids.
- critical care
- rare lung diseases
- viral infection
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Contributors The authors shared data collection, data analyses and data interpretation, as well as preparation, review and approval of the manuscript. The corresponding author had full access to all study data and had final responsibility for the decision to submit for publication. IV, FH-S, PD, FCR, KT, MH, SG, H-DW, FG, SH and WS: acquisition, analyses or interpretation of data. REM, SG, H-DW, SH and WS: literature research and clinical advice. IV: manuscript drafting. IV, FH-S, PD, FCR, KT, MH, REM, SG, H-DW, FG, SH and WS: critical revision of the manuscript for important intellectual content. IV, FH-S, PD and FCR: figure illustration. IV and WS: study supervision.
Funding Grants from the Federal Ministry of Education and Research (German Center for Lung Research [DZL/ALI]; to IV, FG, SH and WS), the German Research Foundation (DFG/CRU309; to IV, REM, FG, SH and WS) and The Cardio-Pulmonary Institute (EXC 2026; Project ID: 390649896; to IV, KT, REM, FG, SH and WS)), the von Behring Röntgen Foundation (Project 66-LV07; to IV) supported this work.
Competing interests None declared.
Patient consent for publication Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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