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Sequential FDG-PET in the management of multiorgan sarcoidosis
  1. Alan Kelly1,
  2. Michael P Keane1,2,
  3. David Keane3,
  4. Jonathan D Dodd4,
  5. David J Murphy4,
  6. Cormac McCarthy1,2
  1. 1Respiratory Medicine, St. Vincent's University Hospital, Dublin, Ireland
  2. 2School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
  3. 3Cardiology, St. Vincent's Uiversity Hospital, Dublin, Ireland
  4. 4Radiology, St. Vincent's University Hospital, Dublin, Ireland
  1. Correspondence to Dr Cormac McCarthy, Medicine, University College Dublin, Dublin 4, Ireland; cormac.mccarthy{at}

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A 32-year-old man presented with palpitations and central chest pain, examination was unremarkable and chest radiograph was normal. ECG demonstrated right axis deviation and inferolateral T-wave inversion; cardiac enzymes were normal. Cardiac MRI demonstrated multifocal, patchy subepicardial and mesocardial left ventricular late gadolinium enhancement, suggestive of cardiac sarcoidosis. Whole body and dedicated cardiac fluorodeoxyglucose (FDG)-positron emission tomography (PET) was performed 60 min after radiotracer injection following a special patient preparation to suppress physiological myocardial uptake of glucose. This consists of a high-fat, low-carbohydrate diet the day before scanning followed by a 15 hours fast. The PET revealed multifocal metabolically active cardiac inflammation, corresponding to the areas of late gadolinium enhancement on MRI and extensive sites …

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  • DJM and CM are joint senior authors.

  • Contributors All authors contributed to manuscript writing and review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon request.

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