CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI −20 to −8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI −21 to −10). CT imaging may improve candidate risk stratification.
- lung transplantation
- imaging/CT MRI etc
- clinical epidemiology
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MRA and IE are joint first authors.
DJL, JDC and JPS are joint senior authors.
Twitter @jskim8223, @davidlederer
Contributors Study design: MRA, IE, DJL, JC and JPS. Data acquisition, analysis, interpretation: MRA, IE, GG, JU, YT, DT, JMD, MKP, SMP, LDS, LB, MA, SA, JRG, SRH, JK, EC, JSK, DG, MRB, RGB, DJL, JC and JPS. First draft of the manuscript: MRA, IE, JC and JPS. Final manuscript review and approval: all authors.
Funding Supported by National Institutes for Health Grants: T32 HL105323, K24 HL131937, R01 HL 114626, R01 HL 134851, R01 HL 087115, K24 HL115354, Stony Wold-Herbert Foundation, VA-ORD: IK2 CX001034.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
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