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Five-year mortality and morbidity impact of prolonged versus brief ICU stay: a propensity score matched cohort study

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  • GH and NVA contributed equally.

  • Contributors Study concept and design: GH and GVdB. Acquisition of data: GH, HVM, PM, YD, AW, JG, JD and PW. Analysis and interpretation of data: GH, NVA and GVdB. Drafting of the manuscript: GH, NVA and GVdB. Critical revision of the manuscript for important intellectual content: GH, NVA, PM, HVM, YD, AW, JG, MPC, JD, RG, PW and GVdB. Statistical analysis: GH, NVA and GVdB. Obtained funding: GH, NVA and GVdB. Administrative, technical support: PW. Study supervision: GH, HVM, PW and GVdB.

  • Funding This work was supported by the Fund for Scientific Research, Flanders Belgium (grant G.0399.12 to GH; Fundamental Clinical Research fellowship to GH: 1805116N, MC: 1700111N; aspirant PhD fellowship to NVA: 1131618N), the clinical research fund (KOF) of the University Hospitals Leuven, Belgium (postdoctoral research fellowship to JG); the Methusalem program of the Flemish Government (METH/08/07 which has been renewed as METH/14/06 via KU Leuven) to GVdB; the European Research Council ERC Advanced grants (AdvG-2012-321670 from the Ideas Program of the EU FP7 and AdvG-2017-785809 from the Horizon 2020 Program of the EU) to GVdB. The authors have no conflict of interest with the sponsors of the study.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study protocol and informed consent forms were approved by the Leuven University Hospital Ethics Committee (ML4190). Patients gave separate informed consent for the five-year morbidity evaluations.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data sharing is offered under the format of collaborative projects. Proposals can be directed to the senior author (GVdB).

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Footnotes

  • GH and NVA contributed equally.

  • Contributors Study concept and design: GH and GVdB. Acquisition of data: GH, HVM, PM, YD, AW, JG, JD and PW. Analysis and interpretation of data: GH, NVA and GVdB. Drafting of the manuscript: GH, NVA and GVdB. Critical revision of the manuscript for important intellectual content: GH, NVA, PM, HVM, YD, AW, JG, MPC, JD, RG, PW and GVdB. Statistical analysis: GH, NVA and GVdB. Obtained funding: GH, NVA and GVdB. Administrative, technical support: PW. Study supervision: GH, HVM, PW and GVdB.

  • Funding This work was supported by the Fund for Scientific Research, Flanders Belgium (grant G.0399.12 to GH; Fundamental Clinical Research fellowship to GH: 1805116N, MC: 1700111N; aspirant PhD fellowship to NVA: 1131618N), the clinical research fund (KOF) of the University Hospitals Leuven, Belgium (postdoctoral research fellowship to JG); the Methusalem program of the Flemish Government (METH/08/07 which has been renewed as METH/14/06 via KU Leuven) to GVdB; the European Research Council ERC Advanced grants (AdvG-2012-321670 from the Ideas Program of the EU FP7 and AdvG-2017-785809 from the Horizon 2020 Program of the EU) to GVdB. The authors have no conflict of interest with the sponsors of the study.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study protocol and informed consent forms were approved by the Leuven University Hospital Ethics Committee (ML4190). Patients gave separate informed consent for the five-year morbidity evaluations.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data sharing is offered under the format of collaborative projects. Proposals can be directed to the senior author (GVdB).

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