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Altered relaxation times in MRI indicate bronchopulmonary dysplasia
  1. Kai Förster1,2,
  2. Birgit Ertl-Wagner3,
  3. Harald Ehrhardt4,
  4. Hannah Busen5,
  5. Steffen Sass5,
  6. Andreas Pomschar3,
  7. Lutz Naehrlich4,
  8. Andreas Schulze1,
  9. Andreas W Flemmer1,
  10. Christoph Hübener6,
  11. Oliver Eickelberg2,7,
  12. Fabian Theis5,8,
  13. Olaf Dietrich3,
  14. Anne Hilgendorff1,2
  1. 1Department of Neonatology, Perinatal Center Grosshadern, Dr von Hauner Children's Hospital, Ludwig Maximilian University of Munich, Munich, Germany
  2. 2Comprehensive Pneumology Center, German Lung Research Center (DZL), Helmholtz Zentrum München, Munich, Germany
  3. 3Department of Radiology, German Lung Research Center (DZL), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany
  4. 4Department of General Pediatrics and Neonatology, German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
  5. 5Institute of Computational Biology, Helmholtz Zentrum München, Munich, Germany
  6. 6Department of Obstetrics and Gynecology, Perinatal Center Grosshadern, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany
  7. 7Division of Respiratory Sciences and Critical Care Medicine, University of Colorado at Denver, Anschutz Medical Campus, Aurora, Colorado, USA
  8. 8Department of Mathematics, Technical University of Munich, Munich, Germany
  1. Correspondence to Dr Anne Hilgendorff, Department of Neonatology, Perinatal Center Grosshadern, Dr von Hauner Children’s Hospital, Ludwig-Maximilians-University, Munich 81377, Germany; A.Hilgendorff{at}med.uni-muenchen.de

Abstract

We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics.

Trial registration DRKS00004600.

  • paediatric lung disaese
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Footnotes

  • Contributors BEW, HE and AH contributed to the conception and design. KF, HE, AWF, CH and OD contributed to acquiring data. KF, BEW, HB, SS, AP, LN, OD and AH contributed to analysis and interpretation. KF, BEW, HB, SS, AS, OE, FT, OD and AH contributed to the drafting of the manuscript for important intellectual content.

  • Funding NWG VH-NG-829 (Helmholtz Association), German Center for Lung Research (Federal Ministry of Science).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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