Article Text
Abstract
Prognosticating idiopathic pulmonary fibrosis (IPF) is challenging, in part due to a lack of sensitive biomarkers. A recent article in Thorax described how hyperpolarised xenon magnetic resonance spectroscopy may quantify regional gas exchange in IPF lungs. In a population of patients with IPF, we find that the xenon signal from red blood cells diminishes relative to the tissue/plasma signal over a 12-month time period, even when the diffusion factor for carbon monoxide is static over the same time period. We conclude that hyperpolarised 129Xe MR spectroscopy may be sensitive to short-term changes in interstitial gas diffusion in IPF.
- idiopathic pulmonary fibrosis
- interstitial fibrosis
- imaging/ct mri etc
- lung physiology
This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
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Footnotes
Contributors Conception and design: NDW, NJS, SAR, SMB and JMW. MRI experiments: NDW, NJS, H-FC, GN, JMW, GC, MR and HM. Postprocessing and statistical analysis: NDW and NJS. Pulmonary function tests: MA and LJS. Manuscript drafting for intellectual content: All authors. Manuscript editing: All authors.
Funding Funding for this study was provided by National Institute for Health Research; Grant number: NIHR- RP-R3-12-027 and Medical Research Council; Grant number: MR/M008894/1.
Disclaimer The views expressed in this publication are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research or the Department of Health.
Competing interests None declared.
Patient consent Not required.
Ethics approval Liverpool Central NHS REC.
Provenance and peer review Not commissioned; externally peer reviewed.
Correction notice This article has been corrected since it was published Online First. The copyright licence was changed from CC BY-NC to CC-BY.
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