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Impact of an increase in the inhaled corticosteroid dose on blood eosinophils in asthma
  1. Marek Lommatzsch,
  2. Maria Klein,
  3. Paul Stoll,
  4. Johann Christian Virchow
  1. Department of Pneumology and Critical Care Medicine, University of Rostock, Rostock, Germany
  1. Correspondence to Dr Marek Lommatzsch, Abteilung für Pneumologie und Internistische Intensivmedizin Zentrum für Innere Medizin, Universität Rostock, Rostock 18057, Germany; marek.lommatzsch{at}med.uni-rostock.de

Abstract

Here, we report that increasing treatment with inhaled corticosteroids (ICS) in patients with not well-controlled asthma from a medium to a high dose results in a profound reduction of blood eosinophils (median fall in blood eosinophil concentrations from 560 to 320 cells/µL). Therefore, ‘normal values’ of blood eosinophils in patients with asthma need to be considered in view of the individual ICS doses of the patients. In addition, increases in the dose of ICS may result in blood eosinophil concentrations which would formally preclude treatment with biologics targeting the interleukin-5 pathway.

  • asthma
  • eosinophil biology

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Footnotes

  • Contributors All authors planned and conducted this clinical study. ML, PS: analysed the data. All authors were involved in the writing and correction of the manuscript.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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