We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025).
Trial registration number PREDICT is registered on clinicaltrials.gov (NCT01162265)
- clinical epidemiology
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Contributors IA conceived and oversaw the design and conduct of this analysis. JS coordinated the study and contributed to study design. CJG, ML, GHB and OMK contributed to study design and recruitment. AL, FD and JJD contributed to study design. CJ conducted statistical analysis with support from AS and JJD and drafted the manuscript. AI and SM recruited participants. VN, MR-R, SS, C-YT and HW performed laboratory work supervised by AL and FD. All authors critically reviewed and contributed to the manuscript. IA is the chief investigator of the PREDICT study; FD and AL are co-PIs.
Funding This work was supported by the National Institute for Health Research [grant numbers NIHR HTA 08/68/01, NIHR SRF-2011-04-001, NIHR NF-SI-0616-10037 to IA]. FD was supported by the Imperial Biomedical Research Centre.
Competing interests CJ has undertaken paid consultancy work for Otsuka Pharmaceutical unrelated to the content of this paper. AL has several issued patents underpinning immunodiagnostics for tuberculosis. The ESAT-6/CFP-10 interferon-gamma ELISpot was commercialised by an Oxford University spin-out company (Oxford Immunotec, Abingdon, UK) from which Oxford University and AL have royalty entitlements.
Patient consent Not required.
Ethics approval PREDICT study was approved by the Brent Research Ethics Committee (reference 10/H0717/14).
Provenance and peer review Not commissioned; externally peer reviewed.
Presented at Interim results of this study were presented at the British Thoracic Society Winter Meeting, London, December 2013 (abstract number S57).
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