We investigated the association between interstitial lung abnormalities (ILA) and self-reported measures of health and functional status in 5764 participants from the Age, Gene/Environment Susceptibility-Reykjavik study. The associations of ILA to activities of daily living (ADLs), general health status and physical activity were explored using logistic regression models. Participants with ILA were less likely to be independent in ADLs (OR 0.70; 95% CI 0.55 to 0.90) to have good or better self-reported health (OR 0.66; 95% CI 0.52 to 0.82) and to participate in physical activity (OR 0.72; CI 0.56 to 0.91). The results demonstrate ILA’s association with worsening self-reported health and functional status.
- idiopathic pulmonary fibrosis
- interstitial fibrosis
- imaging/ct mri etc
Statistics from Altmetric.com
GTA and RKP contributed equally.
Contributors Study design: HH, VG, GMH and GG. Acquisition, analysis or interpretation of the data: GTA, RKP, TAs, SS, EFG, GE, TAr, HH, VG, GMH and GG. Statistical analysis: GTA, RKP, TAs and GMH. Obtained funding: VG, GMH and GG. All authors contributed to the critical revision of the manuscript for important intellectual content.
Funding RKP is supported by a National Institutes of Health (NIH) grant (T32 HL007633). GG is supported by a project grant from the Icelandic Research Fund (141513-051) and from the Landspitali Scientific Fund (A-2015-030, A-2016-023). The Age, Gene/ Environment Susceptibility-Reykjavik study was supported by a National Institute on Aging (NIA) grant (27120120022C), two NIH contracts (N01-AG-1-2100 and HHSN27120120022C), the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association) and the Althingi (the Icelandic Parliament). VG is supported by an NIA grant (27120120022C) and an Icelandic Research Fund project grant (141513-051). GMH is supported by NIH grants (P01 HL114501, R01 HL111024, R01 HL135142, RO1 HL130974) and a project grant from the Icelandic Research Fund (141513-051).
Competing interests None declared.
Ethics approval National Bioethics Committee in Iceland (VSN: 00-063) and National Institute on Ageing Intramural Institutional Review Board.
Provenance and peer review Not commissioned; externally peer reviewed.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.