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Response letter to: the Hispanic paradox further unraveled?
  1. Rhea Powell,
  2. R Graham Barr
  1. Department of Medicine, Columbia University, New York, New York, USA
  1. Correspondence to Dr R Graham Barr, Department of Medicine, Columbia University Medical Center, PH 9 East—Room 105, 630, West 168th St., New York, NY 10032, USA; rgb9{at}

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Dr Young and Ms. Hopkins1 suggest that the lack of a confirmation of the ‘Hispanic paradox’ for lung phenotypes in the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study could be due to differences in the distribution of Hispanic subgroups and lower smoking exposure in MESA compared to the study by Bruse et al.2 As suggested, we repeated our analyses stratifying the Hispanic group into those of Mexican and non-Mexican origin and found similar results to initial findings. In a sensitivity analysis including only those Hispanic-Americans who identified Mexico as their country of origin, we again found that among both women and men, genetic ancestry did …

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  • Correspondence relation to: Powell R, Davidson D, Divers J, et al. Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study. Thorax 2013;68:634–42.

    Young, RP, Hopkins, RJ. The Hispanic paradox further unraveled? Thorax 2013, forthcoming.

  • Funding The MESA and MESA Lung Studies are conducted and supported by the NHLBI (contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 and grants R01 HL-077612, R01 HL-075476 and RC1-HL100543).

  • Competing interests Please see original ICMJE COI forms submitted with the initial article for Drs Powell and Barr. No competing interests related to this letter. In general, RP has no competing interests. RGB received costs of conference travel from Boeringher Ingelheim.

  • Ethics approval IRB from all participating universities and the National Heart Lung Blood Institute (NHLBI).

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Data sharing statement Researchers interested in working with MESA. Investigators are welcome to submit a manuscript proposal or ancillary study proposal directly to the study. Please feel free to review additional materials related to establishing a collaborative relationship with MESA at the following link

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