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With great interest we read the paper of Horsley et al.1 In their prospective observational study they showed significant improvement in indices of ventilation capacity (spirometry) and ventilation heterogeneity (multiple-breath washout (MBW)) after a course of intravenous antibiotics in subjects with cystic fibrosis (CF). There was considerable heterogeneity of lung clearance index (LCI) response as observed previously.2 Here we aim to disentangle underlying physiological mechanisms of this heterogeneous response.
We assessed changes of lung function parameters before and after 23 courses of intravenous antibiotics in 19 children with CF aged 5–18 years. Children performed arterial blood oxygen measurement, nitrogen MBW,3 , …
Footnotes
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Contributors Conceived and designed the experiments: SY, CC, FS, PL. Performed the experiments: SY. Analysed the data: SY, AB, PL. Wrote the paper: SY, PL. Qualified as the guarantor of the paper, took responsibility for the integrity of the work as a whole, from inception to published article: PL.
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Competing interests None.
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Patient consent Obtained.
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Ethics approval Ethics Committee of the Canton of Bern, Switzerland.
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Provenance and peer review Not commissioned; externally peer reviewed.