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Systemic inflammation and lung function in young adults.
  1. Robert J Hancox (bob.hancox{at}
  1. University of Otago, New Zealand
    1. Richie Poulton (richie.poulton{at}
    1. University of Otago, New Zealand
      1. Justina M Greene (justina.greene{at}
      1. McMaster University, Canada
        1. Susan Filsell (sue.rog{at}
        1. University of Otago, New Zealand
          1. Christene R McLachlan (chrismclachlan{at}
          1. University of Otago, New Zealand
            1. Finn Rasmussen (finn0001{at}
            1. Aarhus Community Hospital, Denmark
              1. D Robin Taylor (robin.taylor{at}
              1. University of Otago Medical School, New Zealand
                1. Michael J A Williams (michael.williams{at}
                1. University of Otago, New Zealand
                  1. Avis Williamson (ajillwill{at}
                  1. University of Otago, New Zealand
                    1. Malcolm Sears (searsm{at}
                    1. St Joseph's Healthcare, Canada


                      Background: Impaired lung function is associated with systemic inflammation and is a risk factor for cardiovascular disease in older adults. It is unknown when these associations emerge and to what extent they are mediated by smoking, chronic airways disease, and/or established atherosclerosis. We explored the association between the forced expiratory volume in one second (FEV1) and the systemic inflammatory marker C-reactive protein in young adults.

                      Methods: Associations between spirometric lung function and blood C-reactive protein were assessed in a population-based birth-cohort of approximately 1000 New Zealanders at ages 26 and 32 years. Analyses adjusted for height and sex to account for differences in predicted lung function and excluded pregnant women.

                      Results: There were significant inverse associations between FEV1 and C-reactive protein at both ages. Similar results were found for the forced vital capacity. These associations were similar in men and women and were independent of smoking, asthma, and body mass index.

                      Conclusions: Reduced lung function is associated with systemic inflammation in young adults. This association is not due to smoking, asthma, or obesity. The reasons for the association are unexplained, but the findings indicate that the association between lower lung function and increased inflammation predates the development of either chronic lung disease or clinically significant atherosclerosis. The association between poor lung function and cardiovascular disease may be mediated by an inflammatory mechanism.

                      • C-reactive protein
                      • Inflammation
                      • cohort studies
                      • spirometry

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