Rationale: The responsiveness of the endurance shuttle walk to functional changes following bronchodilation was recently demonstrated, while the current literature suggests that the six-minute walking test is less responsive in that setting.
Objective: To compare bronchodilator-induced changes in exercise performance between the 6-minute walking test and the endurance shuttle walk.
Methods: In a randomised, double-blind, placebo- controlled and crossover trial, 14 patients with chronic obstructive pulmonary disease (FEV1: 50 (8)% predicted) completed two 6-minute walking tests and two endurance shuttle walks, each preceded by the nebulization of either a placebo or 500 μg of ipratropium bromide. Cardiorespiratory parameters were monitored during each walking test with a portable telemetric gas analyser. Quadriceps twitch force was measured with magnetic stimulation of the femoral nerve before and after each walking test.
Results: Six-minute walking distance did not change significantly following bronchodilation despite a significant increase in FEV1 (0.18 (0.09)L, p < 0.001). A similar change in FEV1 (0.18 (0.12)L, p < 0.001) was associated with a significant improvement in the distance walked on the endurance shuttle walk (Δdistance ipratropium bromide-placebo: 144 (219) meters, p = 0.03). Quadriceps muscle fatigue was infrequent (< 15% of patients) after both walking tests.
Conclusion: The endurance shuttle walk is more responsive than the 6-minute walking test to detect changes in exercise performance following bronchodilation.
- exercise test
- shuttle walk
- six-minute walk
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.