High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial

Claudia Crimi; Alberto Noto; Fabiana Madotto; Mariachiara Ippolito; Santi Nolasco; Raffaele Campisi; Stefano De Vuono; Giuseppe Fiorentino; Ioannis Pantazopoulos; Athanasios Chalkias; Alessandro Libra; Alessio Mattei; Raffaele Scala; Enrico M Clini; Begum Ergan; Manel Lujan; Joao Carlos Winck; Antonino Giarratano; Annalisa Carlucci; Cesare Gregoretti; Paolo Groff; Andrea Cortegiani

doi:10.1136/thoraxjnl-2022-218806

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Critical care

Original research

High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial

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Claudia Crimi Respiratory Medicine Unit, Policlinico “G. Rodolico-San Marco” University Hospital, Catania, Italy PubMed articles Google scholar articles
Alberto Noto Department of Human Pathology of the Adult and Evolutive Age “Gaetano Barresi”, Division of Anesthesia and Intensive Care, University of Messina, Policlinico “G. Martino”, Messina, Italy PubMed articles Google scholar articles
Fabiana Madotto Value-Based Healthcare Unit, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy PubMed articles Google scholar articles
Mariachiara Ippolito Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy Department of Anesthesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Palermo, Italy PubMed articles Google scholar articles
Santi Nolasco Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy PubMed articles Google scholar articles
Raffaele Campisi Respiratory Medicine Unit, Policlinico “G. Rodolico-San Marco” University Hospital, Catania, Italy PubMed articles Google scholar articles
Stefano De Vuono Emergency Department, “S. Maria della Misericordia” Hospital, Perugia, Italy PubMed articles Google scholar articles
Giuseppe Fiorentino UOC Fisiopatologia e Riabilitazione Respiratoria, AO dei Colli, Naples, Italy PubMed articles Google scholar articles
Ioannis Pantazopoulos Department of Emergency Medicine, Faculty of Medicine, University of Thessaly, Larisa, Greece PubMed articles Google scholar articles
Athanasios Chalkias Department of Anesthesiology, Faculty of Medicine, University of Thessaly, Larisa, Greece Outcomes Research Consortium, Cleveland, Ohio, USA PubMed articles Google scholar articles
Alessandro Libra Respiratory Medicine Unit, Policlinico “G. Rodolico-San Marco” University Hospital, Catania, Italy Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy PubMed articles Google scholar articles
Alessio Mattei Cardio-Thoracic Department, AOU Città della Salute e della Scienza, Molinette Hospital, Turin, Italy PubMed articles Google scholar articles
Raffaele Scala Pulmonology and Respiratory Intensive Care Unit, S. Donato Hospital, Arezzo, Italy PubMed articles Google scholar articles
Enrico M Clini Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University Hospital of Modena, University of Modena Reggio Emilia, Modena, Italy PubMed articles Google scholar articles
Begum Ergan Department of Pulmonary and Critical Care, Dokuz Eylul University, İzmir, Turkey PubMed articles Google scholar articles
Manel Lujan Pneumology Service, CIBERES, Hospital de Sabadell, Barcelona, Spain PubMed articles Google scholar articles
Joao Carlos Winck Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal Centro De Reabilitação Do Norte, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova De Gaia, Portugal PubMed articles Google scholar articles
Antonino Giarratano Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy Department of Anesthesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Palermo, Italy PubMed articles Google scholar articles
Annalisa Carlucci Department of Medicina e Chirurgia, Università Insubria Varese-Como, Varese, Italy Pulmonary Rehabilitation Unit, Istituti Clinici Scientifici Maugeri, Pavia, Italy PubMed articles Google scholar articles
Cesare Gregoretti Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy Fondazione ‘Giglio’, Cefalù, Palermo, Italy PubMed articles Google scholar articles
Paolo Groff Emergency Department, “S. Maria della Misericordia” Hospital, Perugia, Italy PubMed articles Google scholar articles
Andrea Cortegiani Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy Department of Anesthesia, Intensive Care and Emergency, University Hospital Policlinico Paolo Giaccone, Palermo, Italy PubMed articles Google scholar articles
on behalf of the COVID-HIGH Investigators
Google scholar articles

Correspondence to Prof. Andrea Cortegiani, Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Via del vespro 129, 90127, Palermo, Italy; andrea.cortegiani{at}unipa.it

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Citation

Crimi C, Noto A, Madotto F on behalf of the COVID-HIGH Investigators, et al

High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial

Thorax 2023;78:354-361.

Publication history

Received February 3, 2022
Accepted April 26, 2022
First published May 17, 2022.

Online issue publication

May 16, 2023

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© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ. This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.https://bmj.com/coronavirus/usage

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