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Critical care
Original research
Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39

Authors

  • Shilpa Tiwari-Heckler Gastroenterology, University Hospital Heidelberg Medical Clinic, Heidelberg, Germany Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Ghee Rye Lee Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • James Harbison Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Carola Ledderose Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Eva Csizmadia Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • David Melton Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Quanzhi Zhang Harbin Medical University, Harbin, China PubMed articlesGoogle scholar articles
  • Wolfgang Junger Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Guanqing Chen Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Carl J Hauser Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Leo E Otterbein Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Maria Serena Longhi Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Simon Christopher Robson Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Simon Christopher Robson, Center for Inflammation Research, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA; srobson{at}bidmc.harvard.edu
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Citation

Tiwari-Heckler S, Lee GR, Harbison J, et al
Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39
Thorax 2023;78:151-159.

Publication history

  • Received August 2, 2021
  • Accepted April 4, 2022
  • First published May 25, 2022.
Online issue publication 
January 12, 2023

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© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.