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Airway inflammation in severe asthmatics with acid gastro-oesophageal reflux
  1. Nicole Tanner1,
  2. Sejal Saglani2,3,
  3. Albert M Li1,
  4. Andrew Bush2,3,
  5. Louise Fleming2,3
  1. 1 Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong
  2. 2 National Heart and Lung Institute, Imperial College London, London, UK
  3. 3 Respiratory Paediatrics, Royal Brompton and Harefield NHS Foundation Trust, London, UK
  1. Correspondence to Dr Louise Fleming, National Heart and Lung Institute, Imperial College London, London SW7 2BX, UK; l.fleming{at}


The relationship between childhood asthma and gastro-oesophageal reflux (GOR) is contentious. Recent studies in adult asthmatics suggest that GOR is associated with worse control and differences in sputum proteomics related to epithelial integrity, systemic inflammation and host defence. We assessed 127 children with severe asthma undergoing bronchoscopy and pH study. There were no differences in asthma control or measures of airway inflammation or remodelling when those with acid GOR were compared with those without. These results suggest that acid GOR is not an important comorbidity in paediatric severe asthma.

  • paediatric asthma
  • histology/cytology

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  • Contributors LF, AB and SS devised the study protocol. NT carried out data collection and analysis. All authors contributed to data analysis and the manuscript. AB and LF are joint final authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests LF is an Asthma UK Senior Clinical Fellow and PI in the Asthma UK Centre for Applied Research. AB is an Emeritus NIHR Senior Investigator and PI in the Asthma UK Centre for Applied Research. SS was an NIHR Career Development Fellow.

  • Provenance and peer review Not commissioned; externally peer reviewed.