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Circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis: a new association
  1. Yuben P Moodley1,2,3,4
  1. 1 Centre for Respiratory Health, School of Biomedical Science, The University of Western Australia, Nedlands, Western Australia, Australia
  2. 2 Cell Biology Group, Institute for Respiratory Health, Nedlands, Western Australia, Australia
  3. 3 School of Medicine, The University of Western Australia, Nedlands, Western Australia, Australia
  4. 4 Department of Respiratory Medicine, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
  1. Correspondence to Professor Yuben P Moodley, Centre for Respiratory Health, School of Biomedical Science, The University of Western Australia, Nedlands, WA 6009, Australia; yuben.moodley{at}uwa.edu.au

https://doi.org/10.1136/thoraxjnl-2021-218192

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    The study by Whalen et al 1 has delineated the association between circulating cell-free DNA (ccfDNA) and metabolic derangements in idiopathic pulmonary fibrosis (IPF). They examined healthy controls compared with slow and rapid progressors. The latter was defined as subjects who met any part of a composite outcome (death, acute exacerbation of IPF, relative decline in forced vital capacity of at least 10% or diffusing capacity for carbon monoxide of 15%) during an 80-week follow-up.

    The authors found that ccfDNA levels are elevated in rapid progressors compared with healthy controls and slow progressors with significant associations. ccfDNA is usually released during cell death, such as apoptosis, necrosis, pyroptosis, ferroptosis or extracellular trap-associated cell death (termed ETosis).2 Notably, the release of ccfDNA …

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    Footnotes

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Commissioned; externally peer reviewed.

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