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  • Associations of CT evaluations of antigravity muscles, emphysema and airway disease with longitudinal outcomes in patients with COPD

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Associations of CT evaluations of antigravity muscles, emphysema and airway disease with longitudinal outcomes in patients with COPD
  1. Naoya Tanabe1,
  2. Susumu Sato1,
  3. Kazuya Tanimura1,
  4. Tsuyoshi Oguma1,
  5. Atsuyasu Sato1,
  6. Shigeo Muro2,
  7. Toyohiro Hirai1
  1. 1 Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  2. 2 Respiratory Medicine, Nara Medical University, Kashihara, Nara, Japan
  1. Correspondence to Dr Susumu Sato, Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan; ssato{at}kuhp.kyoto-u.ac.jp

Abstract

Multiple CT indices are associated with disease progression and mortality in patients with COPD, but which indices have the strongest association remain unestablished. This longitudinal 10-year observational study (n=247) showed that the emphysema severity on CT is more closely associated with the progression of airflow limitation and that a reduction in the cross-sectional area of erector spinae muscles (ESMCSA) on CT is more closely associated with mortality than the other CT indices, independent of patient demographics and pulmonary function. ESMCSA is a useful CT index that is more closely associated with long-term mortality than emphysema and airway disease in patients with COPD.

  • COPD ÀÜ Mechanisms
  • imaging/CT MRI
  • emphysema
  • respiratory measurement

https://doi.org/10.1136/thoraxjnl-2020-215085

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    Footnotes

    • Contributors NT designed the study, collected, analysed and interpreted the data, and wrote the manuscript. SS contributed to the study design, analysed and interpreted the data and assisted with editing the manuscript. KT contributed to the study design, data collection and interpretation of data analysis. AS and TO contributed to the study design and data analysis. SM contributed to data collection, analysed and interpreted the data and assisted with editing the manuscript. TH contributed to the data interpretation and support whole management of study. SS takes responsibility for the integrity of the project as a whole, from its inception to the manuscript’s publication.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests NT, SS and TH report a grant from Fujifilm Medical outside the current work.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.